Research & Methods Core

研究

• 批准号: 10673991
• 负责人: KATHERINE S PANAGEAS
• 金额: $ 41.35万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673991
• 关键词: Acceleration; Administrator; Adult; Algorithms; Ambulatory Care Facilities; Artificial Intelligence; Biometry; Cancer Control; Caring; Clinical Trials; Clinical Trials Design; Communication; Complex; Data; Data Science; Development; Digital biomarker; Educational workshop; Electronic Health Record; Equity; Evaluation; Family; Goals; Health; Health Services Research; Health system; Healthcare; Healthcare Systems; Home; Hybrids; Immunooncology; Infrastructure; Institution; Intervention; Journals; Knowledge; Lead; Light; Machine Learning; Malignant neoplasm of prostate; Maps; Memorial Sloan-Kettering Cancer Center; Mentors; Methodology; Methods; Oncology; Ontology; Outcome Measure; Outcomes Research; Patient Outcomes Assessments; Patients; Peer Review; Pilot Projects; Play; Policies; Policy Maker; Postdoctoral Fellow; Predictive Analytics; Provider; Publications; Qualitative Methods; Research; Research Methodology; Research Personnel; Resources; Source; Source Code; Standardization; Statistical Methods; Stream; Taxonomy; Training; Validation; Work; advanced analytics; analytical method; asynchronous encounter; cancer care; care delivery; career; data integration; data management; data standards; data streams; digital; digital delivery; effectiveness evaluation; electronic health data; electronic patient reported outcomes; evidence base; experience; health care delivery; health data; innovation; insight; interoperability; malignant breast neoplasm; method development; multidimensional data; novel; open source; personalized cancer care; pragmatic randomized trial; pragmatic trial; randomized, clinical trials; recruit; research and development; social media; symposium; synchronous contact; telehealth; telehealthcare; tool; treatment as usual; trial comparing; trial design; user-friendly; web site

PROJECT SUMMARY/ABSTRACT The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research Center aims to build the evidence base necessary to establish best practices for telehealth-supported cancer care. It will execute nimble, rigorously designed clinical trials investigating whether and how telehealth can enable more cancer care to be safely, effectively, and equitably provided in patients’ homes. The Research & Methods Core (RMC) is instrumental to the MATCHES research theme: focusing on the development of methods to integrate complex streams of multi-level data from asynchronous and synchronous encounters so as to evaluate the effectiveness and impact of telehealth. Specifically, the RMC will generate, refine, validate, and disseminate novel research methods and outcome measures for the evaluation of telehealth in oncology, including digital biomarkers based on digitally captured data and electronic patient-reported outcomes. These activities will directly advance our goal of developing a paradigm for personalized cancer care delivery. To this goal, the RMC brings high-level expertise, strong infrastructure, extensive resources, and immediately relevant experience in data management, mixed-methods research, biostatistics, advanced predictive analytics (e.g., machine learning, artificial intelligence), and clinical trial design. The RMC will be led by Katherine Panageas, DrPH, a biostatistician with deep expertise in trial design and health services research methods. She has led statistical coordinating centers for multiple large projects, including clinical trials and cancer control studies, and has evaluated complex care delivery innovations. The aims of the RMC are: 1) to provide high-quality data management for the development of research methods in telehealth, 2) to provide methodological and biostatistical support for the cluster-randomized Pragmatic Trial and for pilot studies evaluating MSK@Home, 3) to develop and apply novel statistical and research methods to aid evaluation of telehealth-supported cancer care delivery research and to train early-career investigators in these methods, and 4) to disseminate data, knowledge, and resources via user-friendly, open-source algorithms to accelerate broader implementation of telehealth-enabled home-based care. The RMC will develop a framework for processing and analyzing the multiple data streams generated in the context of telehealth-supported cancer care, as well as play a key role in reviewing and evaluating the research progress of the Center. It will also support the Pragmatic Trial and pilot studies and lead the selection and deployment of further telehealth pilot projects. The RMC will work closely with the MATCH-Light Training Unit of the Administrative Core to train junior investigators in research methods to advance telehealth research to drive personalized, equitable, and efficient oncology care and research.

项目总结/摘要 MATCHES（Making Telehealth Delivery of Cancer Care at Home Effective and Safe）远程医疗研究 中心旨在建立必要的证据基础，以建立远程医疗支持癌症的最佳实践 在乎它将执行灵活，严格设计的临床试验，调查远程医疗是否以及如何 使更多的癌症护理能够安全、有效和公平地在患者家中提供。研究& 核心方法（RMC）有助于MATCHES研究主题：专注于 集成来自异步和同步遭遇的多级数据的复杂流的方法， 以评估远程保健的有效性和影响。具体来说，RMC将生成、细化、验证， 传播新的研究方法和结果措施，以评估肿瘤学中的远程保健， 包括基于数字捕获数据的数字生物标志物和电子患者报告结果。这些 这些活动将直接推动我们制定个性化癌症护理模式的目标。本 为了实现这一目标，RMC提供了高水平的专业知识、强大的基础设施、广泛的资源， 在数据管理，混合方法研究，生物统计学，高级预测分析（例如， 机器学习、人工智能）和临床试验设计。RMC将由凯瑟琳帕纳吉亚斯领导， DrPH是一名生物统计学家，在试验设计和卫生服务研究方法方面具有深厚的专业知识。她领导 多个大型项目的统计协调中心，包括临床试验和癌症控制研究， 并评估了复杂的医疗服务创新。RMC的目标是：1）提供高质量的数据 管理远程保健研究方法的发展，2）提供方法和 为集群随机化实用试验和评估MSK@Home的试点研究提供生物统计学支持， 3)开发和应用新的统计和研究方法，以帮助评估远程医疗支持的癌症 护理提供研究和培训早期职业调查人员在这些方法，和4）传播数据， 知识和资源，通过用户友好的开源算法，以加速更广泛的实施， 远程医疗支持的家庭护理。RMC将制定一个框架，用于处理和分析 远程医疗支持的癌症护理背景下生成的多个数据流，并发挥着关键作用 审查和评估中心的研究进展。它还将支持务实的审判， 开展试点研究，并牵头选择和部署进一步的远程保健试点项目。RMC将工作 与行政核心的MATCH-轻型培训股密切合作，对初级研究人员进行研究培训 推进远程医疗研究的方法，以推动个性化，公平和有效的肿瘤治疗， research.