Deciphering the molecular mechanisms of parasite-host interactions

破译寄生虫与宿主相互作用的分子机制

• 批准号: DP210101337
• 负责人: A/Prof Sheila Donnelly
• 金额: $ 39.86万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101337
• 关键词: Deciphering; molecular; mechanisms; parasite; host

The completion of genome projects for several helminths of veterinary significance has provided novel insights into the fundamentals of helminth biology. One outcome is the identification of microRNAs, a subclass of small regulatory RNAs which in plants and mammalian cells control diverse biological processes at the posttranscriptional level. We have discovered the presence of helminth miRNAs within host cells with the ability to mimic mammalian miRNAs to modulate innate immune responses. This project will discover how helminths hijack the mammalian miRNA machinery to regulate host gene expression and thus support long-term infection. The outcomes will highlight new avenues for the control of these persistent worm infections.

几种具有兽医意义的蠕虫的基因组计划的完成，为蠕虫生物学的基本原理提供了新的见解。一个结果是发现了microRNAs，这是一类在植物和哺乳动物细胞中在转录后水平上控制各种生物学过程的小调节RNA。我们已经发现宿主细胞中存在蠕虫miRNAs，能够模仿哺乳动物的miRNAs来调节先天免疫反应。这个项目将发现蠕虫如何劫持哺乳动物的miRNA机制来调节宿主基因的表达，从而支持长期感染。研究结果将突出控制这些持续蠕虫感染的新途径。