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West Nile virus control through mosquitocidal avian bloodmeals

通过杀蚊禽血粉控制西尼罗河病毒

基本信息

批准号：
10454977
负责人：
BRIAN David FOY
金额：
$ 62.48万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-22 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454977
关键词：
Adverse effects Animals Anthelmintics Arbovirus Infections Arboviruses Area Biological Assay Birds Blinded Blood California Cessation of life Chickens Colorado Columbidae Columbiformes Communities Conduct Clinical Trials Culex (Genus)Culicidae Development Disease Dose Drug Kinetics Environment Epidemic Excipients Flavivirus Formulation Future Galliformes Goals Home Human Incidence Individual Ingestion Insecticides Intervention Ivermectin Marketing Methods Modeling Neighborhoods North America Passeriformes Persons Pharmaceutical Preparations Probability Property Randomized Randomized Controlled Trials Risk Safety Site Sparrows System Technology Testing Toxic effect Treatment Efficacy United States Urban Community Vaccines Virus Diseases West Nile virus Work absorption base cost design enzootic epidemiological model experimental study feeding field study indexing mosquito-borne mosquitocidal novel preference prevent primary outcome risk minimization safety testing suburban communities success tool treatment site vector vector control vector mosquito viral transmission wild bird

项目摘要

Project Summary West Nile virus (WNV) is a mosquito-borne flavivirus, and the leading cause of domestically-acquired arboviral disease in the United States, resulting in significant disease and death every year among humans and other animals. Efficacious, vector-targeted interventions are critically needed, but current vector control methods (primarily insecticides sprayed into the environment) have been inadequate for WNV control. We have been developing and testing stations that contain endectocide-treated bird feed as a way to control WNV transmission to humans in the western U.S., the region which suffers from the highest incidence WNV disease in North America, by targeting the primary bridge vector mosquito, Culex tarsalis. This project is designed to develop endectocide-treated birdfeed as a novel, safe and scientifically-validated way to control the risk of West Nile virus transmission to humans in the western U.S. The concept is that birds will self-medicate by birdfeed stations containing the treated feed, which would be placed as arrays on homeowners' properties, in neighborhoods or in parks. The blood of treated birds would then kill the primary mosquito vectors of West Nile virus that blood feed on them, which would lower the risk of West Nile virus transmission to people who live, work and recreate around the birdfeed stations.

项目总结