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West Nile virus control through mosquitocidal avian bloodmeals

通过杀蚊禽血粉控制西尼罗河病毒

基本信息

批准号：
10454977
负责人：
BRIAN David FOY
金额：
$ 62.48万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-22 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454977
关键词：
Adverse effects Animals Anthelmintics Arbovirus Infections Arboviruses Area Biological Assay Birds Blinded Blood California Cessation of life Chickens Colorado Columbidae Columbiformes Communities Conduct Clinical Trials Culex (Genus)Culicidae Development Disease Dose Drug Kinetics Environment Epidemic Excipients Flavivirus Formulation Future Galliformes Goals Home Human Incidence Individual Ingestion Insecticides Intervention Ivermectin Marketing Methods Modeling Neighborhoods North America Passeriformes Persons Pharmaceutical Preparations Probability Property Randomized Randomized Controlled Trials Risk Safety Site Sparrows System Technology Testing Toxic effect Treatment Efficacy United States Urban Community Vaccines Virus Diseases West Nile virus Work absorption base cost design enzootic epidemiological model experimental study feeding field study indexing mosquito-borne mosquitocidal novel preference prevent primary outcome risk minimization safety testing suburban communities success tool treatment site vector vector control vector mosquito viral transmission wild bird

项目摘要

Project Summary West Nile virus (WNV) is a mosquito-borne flavivirus, and the leading cause of domestically-acquired arboviral disease in the United States, resulting in significant disease and death every year among humans and other animals. Efficacious, vector-targeted interventions are critically needed, but current vector control methods (primarily insecticides sprayed into the environment) have been inadequate for WNV control. We have been developing and testing stations that contain endectocide-treated bird feed as a way to control WNV transmission to humans in the western U.S., the region which suffers from the highest incidence WNV disease in North America, by targeting the primary bridge vector mosquito, Culex tarsalis. This project is designed to develop endectocide-treated birdfeed as a novel, safe and scientifically-validated way to control the risk of West Nile virus transmission to humans in the western U.S. The concept is that birds will self-medicate by birdfeed stations containing the treated feed, which would be placed as arrays on homeowners' properties, in neighborhoods or in parks. The blood of treated birds would then kill the primary mosquito vectors of West Nile virus that blood feed on them, which would lower the risk of West Nile virus transmission to people who live, work and recreate around the birdfeed stations.

项目摘要西尼罗河病毒（West Nile virus，WNV）是一种蚊媒黄病毒，是引起国内获得性虫媒病毒感染的主要原因。疾病在美国，导致重大疾病和死亡，每年在人类和其他动物迫切需要有效的、针对病媒的干预措施，但目前的病媒控制方法（主要是喷洒到环境中的杀虫剂）不足以控制西尼罗河病毒。我们一直开发和测试含有经杀虫剂处理的鸟饲料的站，以控制西尼罗河病毒传播给美国西部的人类，西尼罗河病毒病发病率最高的地区在北美，通过针对主要桥梁媒介蚊子-跗库蚊。该项目旨在开发经杀虫剂处理的鸟饲料，作为一种新的、安全的、经科学验证的方法，西尼罗河病毒在美国西部传播给人类。这个概念是，鸟类将自我繁殖，鸟饲料站含有处理过的饲料，这将被放置在业主的财产阵列，在社区或公园里。经过处理的鸟类的血液将杀死西尼罗河的主要蚊子媒介血液中的病毒，这将降低西尼罗河病毒传播给生活在那里的人的风险，在喂鸟站附近工作和娱乐。