Repeat Ivermectin Mass Drug Administrations for MALaria control II (RIMDAMAL II): a double-blind cluster randomized trial for integrated control of malaria
重复伊维菌素大规模药物管理用于疟疾控制 II (RIMDAMAL II):疟疾综合控制的双盲整群随机试验
基本信息
- 批准号:9754784
- 负责人:
- 金额:$ 70.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:10 year oldAdoptedAfricaAgeAgricultureAllelesAmodiaquineAnopheles GenusAnti-malarial drug resistanceAntimalarialsAntiparasitic AgentsArtemisininsBedsBehavioralBiological AssayBiteBloodBurkina FasoCessation of lifeChemistryChemopreventionChildChildhoodChloroquineClinicalClinical TrialsCluster randomized trialCombined Modality TherapyCommunitiesCountryCulicidaeDevelopmentDoseDouble-Blind MethodDropsDrug CombinationsDrug KineticsDrug resistanceEnsureEntomologyFailureFilarial ElephantiasesFutureGoalsHealthHumanIncidenceIndividualInfectionIngestionInsecticide ResistanceInsecticidesInterventionIvermectinLinkMalariaMeasuresMonitorMorbidity - disease rateMutationOnchocerciasisOrganismParasite ControlParasite resistanceParasitesPharmaceutical PreparationsPhysiologyPlasmodiumPopulationPredispositionPregnant WomenPrevalencePreventionPreventive treatmentPyrimethamine-SulfadoxineRandomized Clinical TrialsRecipeRecording of previous eventsResidual stateResistanceResistance developmentSafetySeasonsSeminalSoutheastern AsiaSporozoitesSulfadoxine-pyrimethamine resistanceTestingTimeagedarmartesunateauthoritybasecombatevidence baseexperimental studyfeedingindexingmalaria transmissionmortalityneglected tropical diseasesneuromuscularnoveloptimismpreservationprimary endpointprimary outcomeprogramspyrethroidrapid diagnosisresistance allelesuccesssurvivorshiptoolvectorvector control
项目摘要
Project Summary / Abstract
Enhanced malaria control efforts since the turn of the century have resulted in notable reductions in malaria
morbidity and mortality. This success has been driven by the widespread distribution of long-lasting insecticide
treated nets and targeted indoor residual spraying of insecticides to combat vectors as well as rapid diagnosing
and treatment of malaria with artemesisin-based combination therapies, and chemoprevention programs for
pregnant women and children. However, malaria control efforts are stagnating because programs targeting both
the vector and the parasite are not well integrated, and the efficacy of both is severely threatened by widespread
resistance of vectors to currently-approved insecticides and spreading resistance of parasites to currently-
approved drugs. We hypothesize that malaria control can be enhanced, and the spread of both insecticide
resistance and antimalarial drug resistance can be curtailed, if vector and parasite control efforts are linked using
the endectocide ivermectin that can target both organisms with another layer of combination therapy to each.
Ivermectin is an antiparasitic drug that is safe and distributed to hundreds of millions of humans each year. It
also efficiently kills malaria vectors that blood feed on treated people and strong evidence suggests it also has
activity against the sporogonic and exoerythrocytic stages of Plasmodium. We will conduct a cluster randomized
clinical trial in Burkina Faso to test whether repeated ivermectin mass drug administrations, integrated into a
monthly delivery platform with the standard malaria control measures of seasonal malaria chemoprevention and
insectide-treated bed net distribution in the Sahel, will reduce childhood malaria incidence and limit resistance
in both mosquitoes and parasites.
项目总结/摘要
自进入世纪以来,加强了疟疾控制工作,使疟疾发病率显著下降
发病率和死亡率。这一成功是由于长效杀虫剂的广泛分发
驱虫蚊帐和有针对性的室内残留喷洒杀虫剂以消灭病媒以及快速诊断
和以青蒿素为基础的联合疗法治疗疟疾,
孕妇和儿童。然而,疟疾控制工作停滞不前,
病媒和寄生虫没有很好地结合在一起,两者的功效受到广泛传播的
病媒对目前批准的杀虫剂的抗药性和寄生虫对目前批准的杀虫剂的抗药性的传播-
批准的药物。我们假设疟疾控制可以得到加强,
如果将病媒和寄生虫控制工作联系起来,
杀内寄生虫剂伊维菌素,可以针对两种生物体,对每种生物体进行另一层联合治疗。
伊维菌素是一种安全的抗寄生虫药物,每年分发给数亿人。它
也有效地杀死疟疾病媒,血液喂养治疗的人,有力的证据表明,它也有
抗疟原虫孢子生殖期和红细胞外期的活性。我们将进行一个随机分组
布基纳法索的临床试验,以测试是否重复伊维菌素大规模给药,整合到一个
每月提供一个平台,提供季节性疟疾化学预防的标准疟疾控制措施,
在萨赫勒地区分发驱虫蚊帐将减少儿童疟疾发病率并限制抗药性
在蚊子和寄生虫身上。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRIAN David FOY其他文献
BRIAN David FOY的其他文献
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{{ truncateString('BRIAN David FOY', 18)}}的其他基金
West Nile virus control through mosquitocidal avian bloodmeals
通过杀蚊禽血粉控制西尼罗河病毒
- 批准号:
10674117 - 财政年份:2020
- 资助金额:
$ 70.43万 - 项目类别:
West Nile virus control through mosquitocidal avian bloodmeals
通过杀蚊禽血粉控制西尼罗河病毒
- 批准号:
10454977 - 财政年份:2020
- 资助金额:
$ 70.43万 - 项目类别:
West Nile virus control through mosquitocidal avian bloodmeals
通过杀蚊禽血粉控制西尼罗河病毒
- 批准号:
10267766 - 财政年份:2020
- 资助金额:
$ 70.43万 - 项目类别:
Repeat Ivermectin Mass Drug Administrations for MALaria control II (RIMDAMAL II): a double-blind cluster randomized trial for integrated control of malaria
重复伊维菌素大规模药物管理用于疟疾控制 II (RIMDAMAL II):疟疾综合控制的双盲整群随机试验
- 批准号:
10468728 - 财政年份:2018
- 资助金额:
$ 70.43万 - 项目类别:
Repeat Ivermectin Mass Drug Administrations for MALaria control II (RIMDAMAL II): a double-blind cluster randomized trial for integrated control of malaria
重复伊维菌素大规模药物管理用于疟疾控制 II (RIMDAMAL II):疟疾综合控制的双盲整群随机试验
- 批准号:
10223135 - 财政年份:2018
- 资助金额:
$ 70.43万 - 项目类别:
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