Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle loss
携带患者特异性细胞和生长因子的微工程支架,用于治疗体积肌肉损失
基本信息
- 批准号:10455027
- 负责人:
- 金额:$ 35.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-11-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAffectAllogenicAutologousBiocompatible MaterialsBiologic CharacteristicBiologicalBiological ProcessBiomimeticsBlood PlateletsBlood VesselsCellsCicatrixClinicComplexDataDiseaseDown-RegulationEconomicsElderlyElectrospinningEngineeringEngraftmentExtracellular MatrixFamily suidaeGelatinGenerationsGrowth FactorHumanHydrogelsImmune responseImpairmentImplantIn VitroInfectionInjuryLeadMechanicsModalityMorbidity - disease rateMusMuscleMuscle FibersMuscle functionMusculoskeletalMusculoskeletal DiseasesMyopathyNatural regenerationNude MiceOperative Surgical ProceduresPainPatientsPeptidesPersonsPlasmaPolymersPopulationProceduresProcessProductionProtocols documentationQuality of lifeRecovery of FunctionRegenerative capacitySecondary toSignal TransductionSiteSkeletal MuscleSoldierSurgical suturesTestingTherapeuticTissue EngineeringTissue GraftsTissuesTraumatic injuryTreatment FactorVascularizationbasecell growthcellular engineeringcostdisabilityfunctional restorationhealingimplantationimprovedin vivoinduced pluripotent stem cellinjuredmechanical propertiesmouse modelmuscle engineeringmuscle regenerationmuscle strengthmuscular structuremusculoskeletal injurymyogenesisnanofibernerve injurynovel strategiesphysical propertypoly(glycerol-sebacate)precursor cellrecruitrelease factorrepairedscaffoldsocialstem cell growthsubcutaneoustwo-dimensionalvolumetric muscle loss
项目摘要
Project Summary/Abstract
Traumatic and non-traumatic musculoskeletal disorders are responsible for substantial morbidity, pain and
disability, affecting athletes, soldiers, active working people and elder population. This implies major social and
economic hurdles, as musculoskeletal injuries represent a cost of $30 billion in U.S. each year. After injury,
different therapeutic approaches are currently used in the clinics, including surgical application of autologous or
allogeneic grafts. Nevertheless, complications are often associated to surgical repair including nerve injury,
infection, scarring, limitations of tissue graft supply, concerns with immunological response and poor healing
capacity of injured tissue. Indeed, natural healing and surgical procedures are inefficient in restoring
functionality of injured muscles, resulting in a poor quality of life. Thus, a new paradigm for the treatment of
musculoskeletal tissue damage is needed that can provide an effective, and long-term therapy for most
patients. Here, we plan to engineer nanofibrous scaffolds with biomimetic mechanical properties that control-
releases angiogenic and myogenic factors eluted through patient specific platelet-rich plasma (PRP). The
nanofibrous scaffolds will be coated with a layer of hydrogel containing culture of induced pluripotent stem cells
derived myogenic precursor cells (iPS-MPCs), which are expected to differentiate into highly organized
myotubes. The accomplishment of the aims of this proposal will be a paradigm shift in engineering muscle
tissues towards their use in treating muscular disorders and provides an effective and long-term therapy for
most patients.
项目总结/文摘
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
In situ printing of scaffolds for reconstruction of bone defects.
- DOI:10.1016/j.actbio.2021.03.009
- 发表时间:2021-03
- 期刊:
- 影响因子:9.7
- 作者:Azadeh Mostafavi;Tuerdimaimaiti Abudula;Carina S. Russell;E. Mostafavi;Tyrell J Williams;N. Salah;A. Alshahrie;Seth P Harris;Seyed Masoud Moosavi Basri;Y. Mishra;T. Webster;Adnan Memić;A. Tamayol
- 通讯作者:Azadeh Mostafavi;Tuerdimaimaiti Abudula;Carina S. Russell;E. Mostafavi;Tyrell J Williams;N. Salah;A. Alshahrie;Seth P Harris;Seyed Masoud Moosavi Basri;Y. Mishra;T. Webster;Adnan Memić;A. Tamayol
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Ali Tamayol其他文献
Ali Tamayol的其他文献
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{{ truncateString('Ali Tamayol', 18)}}的其他基金
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle loss
携带患者特异性细胞和生长因子的微工程支架,用于治疗体积肌肉损失
- 批准号:
10023160 - 财政年份:2019
- 资助金额:
$ 35.65万 - 项目类别:
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle loss
携带患者特异性细胞和生长因子的微工程支架,用于治疗体积肌肉损失
- 批准号:
10254311 - 财政年份:2019
- 资助金额:
$ 35.65万 - 项目类别:
Microengineered scaffolds carrying patient-specific cells and growth factors for treatment of volumetric muscle loss
携带患者特异性细胞和生长因子的微工程支架,用于治疗体积肌肉损失
- 批准号:
10134046 - 财政年份:2019
- 资助金额:
$ 35.65万 - 项目类别:
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