Trigeminal Afferents Regulation of Apical Periodontitis Development
三叉神经传入对根尖牙周炎发展的调节
基本信息
- 批准号:10454305
- 负责人:
- 金额:$ 35.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAddressAffectAfferent NeuronsAlkaline PhosphataseAmyloid beta-ProteinBiochemicalBiologicalBiological AssayBone PainBone ResorptionBone remodelingC FiberCapsaicinCell CommunicationCell LineCellsChemicalsClinicalCoculture TechniquesDataDentalDevelopmentDiseaseFiberFlow CytometryGeneticGoalsHigh Pressure Liquid ChromatographyHumanImmune responseImmunohistochemistryInfectionInflammation MediatorsInvestigationIon ChannelKnowledgeLesionLifeLipidsLiteratureMeasuresMediatingMicrocomputersMicroscopyMineralsMusNeurogliaNeuronsNeuropeptidesNociceptorsOsteoblastsOsteoclastsPF4 GenePainPathogenesisPathologicPathologic ProcessesPathway interactionsPatientsPeriapical PeriodontitisPharmaceutical PreparationsProcessProtein ArrayProteinsProteomicsQuality of lifeQuantitative Reverse Transcriptase PCRReceptor SignalingRegulationResearchRoleSensorySignal PathwaySkeletal systemSpectrophotometryStainsStructureStructure of trigeminal ganglionTestingTherapeuticTimeTissuesTooth LossTransgenic MiceTrigeminal SystemUnited Statesattenuationbasebone lossclinically significantcraniofacialdensitydental infectiondesignexperimental studygel electrophoresisglobal healthimmune functionimmunoreactivityin silicoin vivoinnovationinsightlipidomicsmouse modelnerve supplynovelnovel strategiesnovel therapeuticsoral conditionosteoblast differentiationprecursor cellprematurereceptorrelease factorresponsescreeningtargeted treatmenttomography
项目摘要
Project Summary
Apical periodontitis (AP) is a highly prevalent and debilitating pathological condition marked by
bone resorption and pain as result of dental infections. Many elegant studies have revealed the
functions of immune cells and inflammatory mediators in AP. Despite AP being densely
innervated by trigeminal ganglia (TG) fibers, the participation of these afferents in this disease
process is largely unknown. Our preliminary data demonstrate that TG neurons regulate AP
lesion development. The objective of this proposal is to understand how TG fibers control AP
development, which remains a large gap in knowledge. We, for the first time, propose to
investigate neurons/non-neuronal cell interaction in control of AP development for each of four
major subclasses of TG neurons. This is novel and critically important strategy in approaching
research on regulation of AP development by sensory neurons, since each neuronal sub-class
has distinct function and biochemical make up, including unique sets of receptors, ion channels
and neuropeptides. Hence, it is possible that regulatory potential of TG neuronal subsets could
dramatically vary; and even produce opposite effects on osteoclasts and osteoblasts. So
according to literature and preliminary experiments, we designed a novel strategy on study AP
development by TG neurons. Our central hypothesis is that in response to infection certain
subclasses of TG afferents inhibit bone resorption in apical periodontitis via the regulation of
osteoclastic and osteoblastic activities. This hypothesis will be tested in: Aim 1 examining role
of different subclasses of TG afferents in inhibiting bone resorption and immunological
responses in a murine model of infection-induced AP; Aim 2 defining involvement of different
subclasses of TG neurons on regulation of osteoclastic and osteoblastic functions; and Aim 3
defining and identifying the released soluble factor(s) from different subclasses of TG neurons
and their contribution to modulation of osteoclast and osteoblast functions. We believe that
knowledge generated by this application will have a substantial positive impact from both
scientific and clinical perspectives. Scientifically, this is the principally novel approach in
investigation of AP using subclass-specific TG mouse lines. Moreover, the generated new
insight into interactions between neurons and DCS remodeling will open pathways for further
scientific advancement. Clinically, identification of neuronal regulatory mechanisms could offer
novel strategies and, importantly, targets for developing anti-AP therapeutics.
项目总结
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trigeminal neurons control immune-bone cell interaction and metabolism in apical periodontitis.
- DOI:10.1007/s00018-022-04335-w
- 发表时间:2022-05-31
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Intraretinal Layer Segmentation Using Cascaded Compressed U-Nets.
- DOI:10.3390/jimaging8050139
- 发表时间:2022-05-17
- 期刊:
- 影响因子:3.2
- 作者:
- 通讯作者:
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Anibal Diogenes其他文献
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{{ truncateString('Anibal Diogenes', 18)}}的其他基金
Trigeminal Afferents Regulation of Apical Periodontitis Development
三叉神经传入对根尖牙周炎发展的调节
- 批准号:
9978039 - 财政年份:2018
- 资助金额:
$ 35.86万 - 项目类别:
Trigeminal Afferents Regulation of Apical Periodontitis Development
三叉神经传入对根尖牙周炎发展的调节
- 批准号:
10208856 - 财政年份:2018
- 资助金额:
$ 35.86万 - 项目类别:
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