Training in Clinical Translational Science: Maximizing the Public Health Impact

临床转化科学培训：最大限度地提高公共卫生影响

• 批准号: 10454786
• 负责人: WILLIAM P HETRICK
• 金额: $ 30.08万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454786
• 关键词: Clinical; Public Health; Training; Translational Research

Project Summary/Abstract This program is focused on leveraging two innovative developments in medicine and clinical science to enhance the predoctoral training of psychological and brain scientists to make breakthroughs in understanding, preventing, and treating severe psychopathology. One development, the NIH initiative to foster clinical translational science (CTS), is motivated by the unmet critical need to move clinically-relevant scientific discoveries along the translational pipeline–from basic science to controlled research with clinical populations to dissemination and implementation–in order to make a substantive public mental health impact. A second development, the NIMH Research Domain Criteria (RDoC) initiative, is motivated by the critical need to develop multi-dimensional, multi-unit of analysis approaches to understanding psychopathology. Advances in clinical psychological science will come from a new generation of investigators with expertise at the intersection of these two NIH-driven developments. The ultimate goal of this training program is to maximize the likelihood of producing independent clinical research scientists and leaders with expertise in cutting-edge translational research designs, frameworks, and methodologies that will usher in breakthroughs in the identification of mental illness mechanisms, prevention, and treatment. Following a successful initial training period (years 1–4; 13 trainees), federal funds are requested to continue supporting six predoctoral trainees per year, along with two new institutionally supported trainees, for up to two years. Training opportunities center around four basic aims for each trainee: (1) to gain exposure to foundational concepts, theories, and methodologies, as well as exemplars of both CTS and multiple units of analysis informed by the RDoC; (2) apply this integrated framework to research addressing a public health issue; (3) to learn to foster collaborative opportunities that stretch the boundaries of research both along the CTS continuum and across multiple units of analysis; and, (4) develop professionally to continue this line of research as an independent clinical scientist. Trainees begin their intensive training by identifying a public health issue on which to focus their research efforts. These aims are then realized through: (a) structured research activities under the dual mentorship of a primary and a “stretch” mentor (designed to extend the research either along the CTS continuum or across a unit of analysis); (b) dual research mentoring of the trainee leading to submission of an NRSA application; (c) peer, advanced trainee, and expert guidance and feedback on their research through participation in a year- long seminar; (d) tailored doctoral qualifying examinations; (e) coursework and advanced seminars focused on addressing mental health issues within the CTS and RDoC frameworks; (f) workshops in professional development, responsible conduct of research, and grant writing; and (g) colloquia series and conference attendance to encourage networking and collaborative opportunities. Trainees work with their dual mentors to design an individualized program of study in combination with the activities listed above.

项目摘要/摘要 该计划的重点是利用医学和临床科学的两项创新发展来 加强心理和脑科学家博士前培训，突破认识， 预防和治疗严重的精神病。其中一个进展是，NIH倡议促进临床 翻译科学(CTS)是由未得到满足的关键需求推动的，即推动与临床相关的科学 翻译流水线上的发现--从基础科学到临床人群对照研究 传播和实施--以便对公众心理健康产生实质性影响。一秒钟 NIMH研究领域标准(RDoC)倡议的开发是由以下关键需求推动的 开发多维度、多单元的分析方法来理解精神病理学。最新进展 临床心理科学将来自新一代研究人员，他们在 这两个由NIH驱动的开发项目的交集。该培训计划的最终目标是最大限度地 培养出具有尖端专业知识的独立临床研究科学家和领导者的可能性 翻译研究的设计、框架和方法将在 确定精神疾病的发病机制、预防和治疗。在一次成功的初步培训之后 在此期间(1-4年；13名实习生)，要求联邦资金继续支持每人6名博士前实习生 一年，以及两名新的机构支助的受训人员，最长可达两年。培训机会中心 每个学员大约有四个基本目标：(1)接触基本概念、理论和 方法论，以及研究报告委员会通报的CTS和多个分析单位的样本；(2) 将这一综合框架应用于解决公共卫生问题的研究；(3)学习促进合作 沿着CTS连续体和跨多个单位延伸研究边界的机会 分析；以及，(4)专业发展，作为一名独立的临床科学家继续这一研究领域。 受训者通过确定他们的研究重点是公共卫生问题来开始他们的强化培训 努力。然后通过以下方式实现这些目标：(A)在双重指导下的有组织的研究活动 主要顾问和扩展导师(旨在沿着CTS连续体或跨 分析单位)；(B)对受训人员进行双重研究指导，导致提交国家研究评估申请；(C) 同行、高级实习生和专家通过一年的参与指导和反馈他们的研究- 长时间研讨会；(D)量身定制的博士资格考试；(E)课程作业和高级研讨会，重点是 在CTS和RDoC框架内处理精神健康问题；(F)专业人员讲习班 发展、负责任地开展研究和撰写赠款；(G)系列讨论会和会议 出席会议，鼓励建立联系和协作的机会。学员在他们的双重导师的帮助下 结合上面列出的活动，设计个性化的学习计划。