Training in Clinical Translational Science: Maximizing the Public Health Impact

临床转化科学培训：最大限度地提高公共卫生影响

• 批准号: 9119061
• 负责人: WILLIAM P HETRICK
• 金额: $ 27.96万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119061
• 关键词: Clinical; Public Health; Training; Translational Research

 DESCRIPTION: This program is focused on leveraging two new and innovative developments in medicine and clinical science to enhance the pre-doctoral training of psychologists to make breakthroughs in understanding, preventing, and treating severe psychopathology. One development, the NIH initiative to foster clinical translational science (CTS), is motivated by the unmet critical need to move clinically-relevant scientific discoveries along the translational pipeline-from basic science to controlled research with clinical populations to dissemination and implementation-in order to make a substantive public mental health impact. A second development, the NIMH Research Domain Criteria (RDoC) initiative, is motivated by the critical need to develop multi-dimensional, multi-unit of analysis approaches to understanding psychopathology. Advances in clinical psychological science will come from those with expertise at the intersection of these two NIH-driven developments. The ultimate goal of this program is to maximize the likelihood of producing independent clinical research scientists and leaders with expertise in cutting-edge translational research designs, frameworks, and methodologies that will usher in breakthroughs in the identification of mental illness mechanisms, prevention, and treatment. Funds are requested to support six pre-doctoral trainees per year. Unique training opportunities center around four basic aims for the trainees: (1) gain exposure to foundational concepts, theories, and methodologies, as well as exemplars of both CTS and multiple units of analysis informed by the RDoC; (2) apply this integrated framework to research addressing a public health issue; (3) learn to foster collaborative opportunities that stretch the boundaries of research both along the CTS continuum and across multiple units of analysis; and, (4) develop professionally to continue this innovative line of research eventually as an independent clinical scientist. Trainees begin their intensive training by identifying a public health issue on which to focus their research efforts. These aims are then realized through: (a) structured research activities under the dual mentorship of a primary and a "stretch" mentor (designed to extend the research either along the CTS continuum or across a unit of analysis); (b) dual research mentoring of the trainee leading to submission of an NRSA application; (c) peer, advanced trainee, and expert guidance and feedback on their research through participation in a year-long seminar; (d) tailored doctoral qualifying examinations; (e) coursework and advanced seminars focused on addressing mental health issues within the CTS and RDoC frameworks; (f) workshops in professional development, responsible conduct of research, and grant writing; and (g) colloquia series, retreats, and conference attendance to encourage networking and collaborative opportunities. Trainees work with their dual mentors to design an individualized program of study in combination with the activities listed above, culminating in completion of a doctoral minor in clinical translational psychological science.

 描述：该项目的重点是利用医学和临床科学领域的两项新的创新发展来加强心理学家的博士前培训，以在理解、预防和治疗严重精神病理学方面取得突破。 NIH 促进临床转化科学 (CTS) 的一项发展是由 尚未满足的关键需求是，将临床相关的科学发现沿着转化途径推进——从基础科学到临床人群的对照研究，再到传播和实施——以便对公众心理健康产生实质性影响。第二个发展是 NIMH 研究领域标准 (RDoC) 计划，其动机是迫切需要开发多维度、多单元的分析方法来理解精神病理学。临床心理科学的进步将来自于那些在这两个 NIH 驱动的发展交叉领域拥有专业知识的人。该项目的最终目标是最大限度地提高培养具有尖端转化研究设计、框架和方法专业知识的独立临床研究科学家和领导者的可能性，这些科学家和领导者将在精神疾病机制的识别、预防和治疗方面带来突破。每年请求资金支持六名博士前培训生。独特的培训机会围绕学员的四个基本目标：(1) 接触基本概念、理论和方法，以及 RDoC 提供的 CTS 和多个分析单元的范例； (2) 将这一综合框架应用于解决公共卫生问题的研究； (3) 学会培育突破界限的合作机会 沿着 CTS 连续体和跨多个分析单元进行研究； (4) 专业发展，最终作为一名独立的临床科学家继续这一创新研究路线。学员通过确定一个公共卫生问题来开始强化培训 集中他们的研究工作。然后通过以下方式实现这些目标： (a) 在主要导师和“延伸”导师的双重指导下开展结构化研究活动（旨在沿着 CTS 连续体或跨分析单元扩展研究）； (b) 对受训者进行双重研究指导，以提交 NRSA 申请； (c) 通过参加为期一年的研讨会，获得同行、高级实习生和专家的研究指导和反馈； (d) 量身定制的博士资格考试； (e) 课程作业和高级研讨会侧重于解决 CTS 和 RDoC 框架内的心理健康问题； (f) 专业发展、负责任的研究行为和赠款写作方面的讲习班； (g) 系列座谈会、务虚会和出席会议，以鼓励建立联系和合作机会。学员与他们的双重导师合作，结合上述活动设计个性化的学习计划，最终完成临床转化心理科学的博士学位辅修课程。