“CRCNS: Computational principles of memory based decision making in Drosophila”

–CRCNS:果蝇基于记忆的决策的计算原理 –

基本信息

  • 批准号:
    10456950
  • 负责人:
  • 金额:
    $ 19.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Decision making largely depends on the integration of prior sensory experiences that are stored in the brain as memories. One of the best-understood model systems of a two-choice decision process is associative olfactory memory in Drosophila. In the fly, learning occurs at the synapse between Kenyon cells (KCs) and mushroom body output neurons (MBONs). By pairing olfactory stimuli with a reward or a punishment flies can reliably learn to distinguish two initially neutral odors. As in mammals, dopaminergic neurons (DANs) represents this contextual valence and modulate the strength or connectivity of KC>MBON synapses within distinct compartments of the MB, consequently altering behavior. To understand how this decision making is encoded in memory we thus must first understand the computation performed within individual DAN-KC-MBON modules. In preliminary work, we built a realistic computational model of the MBON-3 neuron including the precise synaptic connectivity all 948 innervating KCs based on the complete synaptic connectome of the MB. Our model incorporates precise membrane properties of the MBON-3 neuron that we obtained by performing patch-clamp recording in vivo. We demonstrate that MBON-3 is electrotonically compact and show that activation of complex KC input patterns reflecting physiological activation by individual odors in vivo are sufficient to robustly drive MBON spiking. Here, we will combine experimental analysis in vivo with computational modelling to determine the mechanisms controlling MBON activation under baseline conditions and in response to memory-induced plasticity. We will identify the minimal number of KCs and KC synapses required for robustMBON activation for different subsets of approach and avoidance MBONs in vivo. These data will guide computational approaches to identify general and specific features of the KC-MBON interactions. The results will then serve to identify compartment-specific plasticity mechanisms in vivo, and corresponding computational mechanisms in silico. Finally, we extend these approaches to simultaneous analyses at multiple KC-MBON modules to provide a computational basis for decision-making.
决策在很大程度上取决于储存在大脑中的先前感官经验的整合

项目成果

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{{ truncateString('ERNST NIEBUR', 18)}}的其他基金

“CRCNS: Computational principles of memory based decision making in Drosophila”
–CRCNS:果蝇基于记忆的决策的计算原理 –
  • 批准号:
    10653144
  • 财政年份:
    2021
  • 资助金额:
    $ 19.77万
  • 项目类别:
“CRCNS: Computational principles of memory based decision making in Drosophila”
–CRCNS:果蝇基于记忆的决策的计算原理 –
  • 批准号:
    10397787
  • 财政年份:
    2021
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS: Neural decision mechanisms: from value-encoding to preference reversal
CRCNS:神经决策机制:从价值编码到偏好逆转
  • 批准号:
    9105756
  • 财政年份:
    2015
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS: Neural decision mechanisms: from value-encoding to preference reversal
CRCNS:神经决策机制:从价值编码到偏好逆转
  • 批准号:
    9272869
  • 财政年份:
    2015
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS-Attentional Selection and Perceptual Organization
CRCNS-注意选择和知觉组织
  • 批准号:
    7269848
  • 财政年份:
    2004
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS: Attentional Selection and Perceptional Organization
CRCNS:注意选择和感知组织
  • 批准号:
    7735960
  • 财政年份:
    2004
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS: Attentional Selection and Perceptional Organization
CRCNS:注意选择和感知组织
  • 批准号:
    7881554
  • 财政年份:
    2004
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS-Attentional Selection and Perceptual Organization
CRCNS-注意选择和知觉组织
  • 批准号:
    6887924
  • 财政年份:
    2004
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS: Attentional Selection and Perceptional Organization
CRCNS:注意选择和感知组织
  • 批准号:
    8132314
  • 财政年份:
    2004
  • 资助金额:
    $ 19.77万
  • 项目类别:
CRCNS-Attentional Selection and Perceptual Organization
CRCNS-注意选择和知觉组织
  • 批准号:
    6942244
  • 财政年份:
    2004
  • 资助金额:
    $ 19.77万
  • 项目类别:

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