Environmental stress and epigenetic repression in the developing embryo

发育中胚胎的环境应激和表观遗传抑制

• 批准号: 10456914
• 负责人: Mary Grace Goll
• 金额: $ 22.65万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456914
• 关键词: Address; Adopted; Adult; Affect; DNA Damage; DNA Sequence; Data; Development; Disease; Embryo; Embryonic Development; Endocrine Disruptors; Environmental Impact; Epidemiology; Epigenetic Process; Exposure to; Foundations; Future; Gene Silencing; Genes; Genetic Transcription; Genome; Genomic Instability; Health; Heavy Metals; Histone H3; Immune system; Link; Literature; Lysine; Modeling; Modification; Molecular; Monitor; Onset of illness; Outcome; Pathology; Predisposition; Public Health; Refractory; Repetitive Sequence; Reporter; Reporting; Repression; Research; Research Design; Rest; Risk; Satellite DNA; Standardization; Stress; Testing; Tissues; Transgenes; Transgenic Organisms; Zebrafish; analysis pipeline; base; derepression; early life exposure; environmental agent; environmental stressor; epigenome; histone modification; immune activation; improved; in vivo; in vivo monitoring; innovation; interest; prenatal exposure; public health relevance; stressor; success; tool; vertebrate genome; zebrafish development

Project Summary Epidemiological and experimental evidence suggest that early life exposure to environmental stress can have long-term health consequences. Epigenetic changes represent one mechanism linking prenatal exposures to latent health outcomes. However, despite the clear

项目总结