Chemistry Core

化学核心

• 批准号: 10456976
• 负责人: DOUGLAS F COVEY
• 金额: $ 62.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10456976
• 关键词: Allopregnanolone; Antidepressive Agents; Automobile Driving; Cell membrane; Cellular Stress; Chemistry; Clinical Research; Databases; Evolution; Impact evaluation; Ion Channel; Major Depressive Disorder; Mental Depression; Molecular Target; N-Methyl-D-Aspartate Receptors; Pathway interactions; Pharmacotherapy; Photoaffinity Labels; Physiological; Postpartum Depression; Psychiatric therapeutic procedure; Psychiatry; Recording of previous events; Research Personnel; Site; Testing; academic program; analog; clinical efficacy; improved; neurosteroids; novel; novel strategies; receptor; side effect

Abstract The center uses novel strategies to determine the mechanism(s) of action for the anti- depressant actions of neurosteroids. A panel of neurosteroid analogues with a range of previously determined mechanisms of action will be synthesized in the Chemistry Core for use in all Projects in the center. These include analogues with actions at NMDA receptors, GABAA receptors, Ca2+- channels, and intracellular targets. New tethered compounds will be synthesized to restrict actions to plasma-membrane channels. Existing and proposed photoaffinity labeling neurosteroids will be prepared in the core and used in Project 1 to identify novel sites. The core is a hub for evaluation of the impact of neurosteroids with varied cellular actions.

摘要 该中心采用新颖的策略来确定抗癌药物的作用机制(S)。 神经类固醇的抑郁作用。一组神经类固醇类似物，具有一系列 先前确定的作用机制将在化学核心中合成以供使用 在中心的所有项目中。这些包括作用于NMDA受体的类似物，GABAA 受体、钙通道和细胞内靶点。新的系留化合物将是 合成以限制对质膜通道的作用。现有的和建议的 将在核心制备光亲和标记神经类固醇，并在项目1中用于鉴定 新奇的网站。核心是评估神经类固醇对不同细胞的影响的中心。 行为。