MEDICINAL CHEMISTRY OF STEROIDS

类固醇的药物化学

• 批准号: 7721490
• 负责人: DOUGLAS F COVEY
• 金额: $ 0.04万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721490
• 关键词: Area; Bile fluid; Biological; Biology; Chemistry; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Homeostasis; Institution; Laboratories; Natural Products Chemistry; Pharmaceutical Chemistry; Research; Research Personnel; Resources; Source; Steroids; United States National Institutes of Health; Universities; interest; steroid analog

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in the chemistry and biology of steroids. My laboratory specializes in natural products chemistry as it relates to the synthesis of steroids and steroid analogues. The compounds prepared in the laboratory are then studied in laboratories of colleagues throughout the university, and elsewhere, who share with us a common interest in the biological actions of steroids. Currently our efforts are focused in three main areas: neuroactive steroids; neuroprotective steroids; and cholesterol and bile steroid homeostasis.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们对类固醇的化学和生物学感兴趣。我的实验室专门研究天然产物化学，因为它涉及类固醇和类固醇类似物的合成。然后，在实验室制备的化合物在整个大学和其他地方的同事的实验室中进行研究，他们与我们对类固醇的生物作用有共同的兴趣。目前，我们的努力集中在三个主要领域：神经活性类固醇;神经保护类固醇;胆固醇和胆汁类固醇稳态。