Chemistry Core

化学核心

• 批准号: 10198245
• 负责人: DOUGLAS F COVEY
• 金额: $ 68.03万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10198245
• 关键词: Allopregnanolone; Antidepressive Agents; Automobile Driving; Cell membrane; Cellular Stress; Chemistry; Clinical Research; Databases; Evolution; Impact evaluation; Ion Channel; Major Depressive Disorder; Mental Depression; Molecular Target; N-Methyl-D-Aspartate Receptors; Pathway interactions; Pharmacotherapy; Photoaffinity Labels; Physiological; Postpartum Depression; Psychiatric therapeutic procedure; Psychiatry; Recording of previous events; Research Personnel; Site; Testing; academic program; analog; clinical efficacy; improved; neurosteroids; novel; novel strategies; receptor; side effect

Abstract The center uses novel strategies to determine the mechanism(s) of action for the anti- depressant actions of neurosteroids. A panel of neurosteroid analogues with a range of previously determined mechanisms of action will be synthesized in the Chemistry Core for use in all Projects in the center. These include analogues with actions at NMDA receptors, GABAA receptors, Ca2+- channels, and intracellular targets. New tethered compounds will be synthesized to restrict actions to plasma-membrane channels. Existing and proposed photoaffinity labeling neurosteroids will be prepared in the core and used in Project 1 to identify novel sites. The core is a hub for evaluation of the impact of neurosteroids with varied cellular actions.

摘要