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The Development of Vestibular-Perceptual Adaptation Paradigms for Treating Persistent Vertigo & Perceived Disequilibrium

治疗持续性眩晕的前庭知觉适应范式的发展

基本信息

批准号：
10456901
负责人：
Eric Richard Anson
金额：
$ 15.13万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10456901
关键词：
Achievement Address Adult Affect Anxiety Area Arousal Attention Basic Science Behavioral Brain Concussion Caring Chronic Clinic Cognition Cognitive Cognitive Therapy Complex Data Development Disease Dizziness Doctor of Philosophy Emotional Emotions Ensure Equilibrium Equipment Etiology Exercise Eye Abnormalities Eye Movements Foundations Functional disorder Future Goals Health Hearing Height Human Individual K-Series Research Career Programs Lead Life Link Measures Medical Mentors Methods Motion Motion Perception Movement Musculoskeletal Equilibrium National Institute on Deafness and Other Communication Disorders Pathology Patients Perception Peripheral Physiological Physiology Play Posture Proprioception Psychophysics Quality of life Recovery Reflex action Reflex eye movement Rehabilitation therapy Research Research Methodology Research Personnel Research Training Resources Role Rotation Science Scientist Sensory Series Statistical Methods Strategic Planning Symptoms Testing Training Translational Research Translations Universities Vertigo Vestibular Diseases Vision cohort effective therapy emotion regulation experience fall risk falls improved improved outcome innovation insight multidisciplinary multisensory novel strategies rehabilitation strategy sensory integration stressor therapy development vestibular reflex vestibulo-ocular reflex virtual

项目摘要

Vertigo/disequilibrium is a frequent medical complaint for individuals with peripheral vestibular disorders or after concussion, especially individuals with lengthy recovery periods. Concussion and vestibular disease often result in vertigo/disequilibrium, abnormal eye movements, altered self-motion perception, and imbalance. Degraded vestibular perception has recently been linked to balance problems. Despite existing therapies to retrain balance and reflexive eye movements, little is known about the role that self-motion perception plays in the recovery from persistent vertigo/disequilibrium or how to effectively re-train these abnormal perceptions. This career development award will establish Dr. Eric Anson as a clinician scientist with expertise in human vestibular research including basic science ranging from physiology to perception and translational science to enhance the care and quality of life for individuals experiencing chronic dizziness/vertigo. This K23 will ensure Dr. Anson develops expertise in 3 primary domains: 1) Advanced concussion management training; 2) Influence of cognition and emotion on SmP; and 3) statistical methods, perceptual psychophysics, and vestibulo-ocular reflex (VOR) adaptation. Dr. Anson has assembled a multi-disciplinary team of experts in concussion management (Jeffery Bazarian, MD, MPH), cognitive and emotional impacts on balance (Mark Carpenter, PhD; Jeffery Staab, MD), vestibular adaptation (Michael Schubert, PT, PhD), and perceptual psychophysics (Benjamin Crane, MD, PhD; Mark Carpenter, PhD; Jeremy Jamieson, PhD) to facilitate achievement of his goals. Dr. Anson will conduct a series of studies to answer these important questions. He will investigate whether different disease states (concussion and vestibular disease) with similar symptoms lead to differences in self- motion perception (Aim 1). He will determine whether vestibular reflexes and vestibular self-motion perception adapt independently (Aim 2). He will use balance-related anxiety at high heights to investigate the link between emotional regulation, body sway, and self-motion perception (Aim 3). This research plan leverages unique existing resources at the University of Rochester including the CTSI and equipment in the labs of Drs. Anson, Crane, Bazarian, and Jamieson. Dr. Carpenter’s research lab provides access to unique resources for exploring balance-related anxiety as a stressor and training methods to enhance self-motion perception. Dr. Staab’s clinic and research lab provide access to unique resources for training in cognitive behavioral therapy and patients with behavioral variables that contribute to persistent vertigo. The proposed training and mentored research are consistent with the NIDCD strategic plan for research in hearing and balance, specifically addressing current understanding of self-motion perception in health and disease. The proposed training will be the foundation for future R01 applications using self-motion perceptual training to enhance current vestibular rehabilitation, improving quality of life for individuals with vestibular disease or concussion.

眩晕/平衡不平衡是患有外周前庭疾病或脑震荡后，尤其是恢复期较长的人。脑震荡和前庭疾病通常导致眩晕/不平衡、异常眼球运动、改变的自我运动感知和不平衡。前庭感知能力下降最近被认为与平衡问题有关。尽管现有的治疗方法，重新训练平衡和反射性眼球运动，很少有人知道自我运动知觉在其中扮演的角色。从持续性眩晕/不平衡中恢复或如何有效地重新训练这些异常的感知。这个职业发展奖将建立博士埃里克安森作为一个临床科学家与专业知识的人类前庭研究包括基础科学，从生理学到感知和转化科学，提高对慢性头晕/眩晕患者的护理和生活质量。K23将确保博士安森在3个主要领域发展专业知识：1）高级脑震荡管理培训; 2）认知和情绪对SmP的影响; 3）统计方法，知觉心理物理学，前庭眼反射（VOR）适应。安森博士组建了一个多学科专家小组，脑震荡管理（Jeffery Bazarian，MD，MPH），认知和情绪对平衡的影响（Mark Carpenter，PhD; Jeffery Staab，MD）、前庭适应（Michael Schubert，PT，PhD）和知觉适应（Perceptual 心理物理学（Benjamin起重机，医学博士，博士; Mark Carpenter，博士; Jeremy Jamieson，博士），以促进实现他的目标。安森博士将进行一系列的研究来回答这些重要的问题。他将调查是否具有相似症状的不同疾病状态（脑震荡和前庭疾病）导致自我- 运动知觉（目标1）。他将确定前庭反射和前庭自我运动知觉独立适应（目标2）。他将使用与平衡有关的焦虑在高处调查之间的联系，情绪调节、身体摇摆和自我运动感知（目标3）。这项研究计划利用了独特的罗切斯特大学的现有资源，包括CTSI和安森博士实验室的设备，起重机巴扎里安和杰米森。卡彭特博士的研究实验室提供了访问独特的资源，探讨平衡相关焦虑作为一种应激源，以及增强自我运动知觉的训练方法。博士 Staab的诊所和研究实验室为认知行为疗法的培训提供了独特的资源以及行为变量导致持续性眩晕的患者。拟议的培训和指导研究与NIDCD的听力和平衡研究战略计划一致，特别是解决目前对健康和疾病中自我运动感知的理解。拟议的培训将是未来R 01应用的基础，使用自运动感知训练来增强电流前庭康复，改善前庭疾病或脑震荡患者的生活质量。