Prairie voles as a novel model for the effects of pair bonds on aging

草原田鼠作为配对债券对衰老影响的新模型

• 批准号: 10458994
• 负责人: Karen L. Bales
• 金额: $ 75.18万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458994
• 关键词: Adipose tissue; Adult; Affect; Age; Age-Months; Aging; Animal Model; Anxiety; Area; Behavior; Behavioral; Biological; Blood Pressure; Body Composition; Brain; Buffers; Caenorhabditis elegans; Cardiac; Cardiometabolic Disease; Cardiovascular system; Characteristics; Chronic stress; Cognition; Cognitive; Dementia; Development; Diabetes Mellitus; Disease; Distress; Emotional; Emotions; Family Relationship; Female; Foundations; Friendships; Gene Expression; Glucose; Goals; Grief reaction; Hand Strength; Health; Health Benefit; Heart; Heart Diseases; Hormones; Human; Hypothalamic structure; Impairment; Incidence; Individual; Infrastructure; Learning; Link; Lipids; Loneliness; Longevity; Marriage; Measures; Mediating; Memory; Mental Depression; Metabolic; Metabolic syndrome; Metabolism; Microtus; Modeling; Molecular; Muscular Atrophy; Neurohormones; Neurons; Neurosecretory Systems; Organ; Outcome; Oxytocin; Oxytocin Receptor; Pair Bond; Parents; Partner in relationship; Performance; Peripheral; Pharmacology; Physiology; Plasma; Play; Population; Psychological Stress; Research Personnel; Rodent; Rodent Model; Role; Same-sex; Siblings; Skeletal Muscle; Social Conditions; Social Interaction; Social isolation; Social support; Stimulus; Stress; System; Testing; Time; Tissues; Touch sensation; Variant; Work; behavior test; behavioral impairment; blood pressure reduction; cardiometabolism; cardiovascular disorder risk; cognitive function; depressive symptoms; frailty; glucose tolerance; healthspan; healthy aging; hypothalamic-pituitary-adrenal axis; improved; indexing; insight; male; mortality; neurophysiology; novel; offspring; prairie vole; preference; receptor; receptor binding; response; sex; social; social attachment; social relationships; social stress; stressor; stroke risk; young adult

Project Summary Social relationships are crucially important to human health. The effects of social relationships on healthy aging are seen in several systems, including the cardiovascular system, metabolism, emotion, and cognitive function. The effects of social isolation and loneliness have been shown to independently increase risk for stroke, heart disease, and overall mortality. High quality social support, in contrast, can play a positive role in healthy aging including reducing metabolic syndrome and adverse cardiovascular outcomes. Long-term partnerships (such as marriage) are the primary close relationship in many adults, but other types of relationships such as sibling relationships, other family relationships, and friendships, may also support healthy aging. Prairie voles are an excellent rodent model of social relationships, in that they show classic behavioral characteristics of an attachment bond: adult males and females form pair bonds, which are characterized by a preference for the familiar partner, distress upon separation, and the ability of the partner to provide a social buffer against stress. These behavioral characteristics in prairie voles provide researchers with the ability to examine the effects of specific types of affiliative relationships (pair mates, siblings, parent-offspring) in adult males as well as in females. The hormone oxytocin has been established as a foundational mechanism in the neurophysiology of relationship formation, relationship quality and partner loss. Its secretion is stimulated by a wide variety of social stimuli, including social touch, sex and social stress. Its receptor is widespread throughout the body. As such, it presents a potential unifying mechanism for organismal-scale effects of social relationships on the brain and the body. Here we will examine how long-term social relationships influence cardiac, metabolic, cognitive and emotional health across the lifespan. Our general approach is to use prairie voles, both males and females, in differing social conditions (pair-bonded, housed with same-sex sibling, or isolated) to examine the effects of presence of a relationship, type of that relationship, and quality of that relationship on cardiac and metabolic health, behavioral and cognitive health, and longevity. We will longitudinally assess measures of cardiac, metabolic, behavioral, and cognitive function at three timepoints: 6, 18, and 24 months of age. We will assess changes in the OT system across aging, on both brain and peripheral tissues (heart, adipose tissue, and skeletal muscle). Finally, we will explore how relationships change over time, and how loss of a partner affects healthy aging.

项目摘要 社会关系对人类健康至关重要。社会关系对 健康的老龄化在几个系统中可见，包括心血管系统，新陈代谢，情绪， 认知功能社会孤立和孤独的影响已经被证明是独立增加的 中风、心脏病和总死亡率的风险。相反，高质量的社会支持可以发挥积极的作用， 在健康老龄化中的作用，包括减少代谢综合征和不良心血管结局。长期 伴侣关系（如婚姻）是许多成年人的主要亲密关系，但其他类型的伴侣关系也是如此。 诸如兄弟姐妹关系、其他家庭关系和友谊等关系也可以支持健康。 衰老 草原田鼠是一种很好的啮齿动物社会关系模型，因为它们表现出典型的行为模式， 依恋键的特征：成年雄性和雌性形成配对键，其特征是 对熟悉的伴侣的偏好，分离时的痛苦，以及伴侣提供社交能力的能力 缓冲压力。草原田鼠的这些行为特征为研究人员提供了 研究特定类型的从属关系（配偶，兄弟姐妹，父母-后代）在成年人中的影响 无论是男性还是女性。激素催产素已被确立为一个基本的机制， 关系形成、关系质量和伴侣流失的神经生理学。它的分泌是由一种 各种各样的社会刺激，包括社会接触，性和社会压力。它的受体分布广泛 在整个身体。因此，它提出了一个潜在的统一机制，生物规模的影响，社会 大脑和身体的关系。 在这里，我们将研究长期的社会关系如何影响心脏，代谢，认知和 在整个生命周期中的情绪健康。我们的一般方法是使用草原田鼠，无论是雄性还是雌性， 不同的社会条件（成对结合，与同性兄弟姐妹住在一起，或孤立），以检查 关系的存在、该关系的类型以及该关系对心脏和代谢的质量 健康、行为和认知健康以及长寿。我们将纵向评估心脏， 在三个时间点：6、18和24个月龄时的代谢、行为和认知功能。我们将评估 OT系统在衰老过程中的变化，在大脑和外周组织（心脏，脂肪组织， 骨骼肌）。最后，我们将探讨关系如何随着时间的推移而变化，以及失去伴侣如何影响 健康老龄化