MCSP TORFP NO. NIH-NINDS-20-02: MOURADIAN/DISNEY - BASE EC (PARKINSON'S)
MCSP TORFP 编号
基本信息
- 批准号:10457230
- 负责人:
- 金额:$ 33.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2021-09-30
- 项目状态:已结题
- 来源:
- 关键词:Biological AssayChemistryComputer AssistedContractsDataDevelopmentDrug CompoundingEnzymesEvaluationExcretory functionGoalsGrantHealthHumanIn VitroIndividualInstitutesIntellectual PropertyInvestigational DrugsInvestigational New Drug ApplicationLeadLegal patentLigandsLogisticsMetabolicMetabolismParkinson DiseasePharmaceutical ChemistryPhasePreparationPropertyRegulationResearch PersonnelRightsServicesShippingStrokeStructure-Activity RelationshipSystemTestingTherapeuticToxicologyUnited States Dept. of Health and Human ServicesUnited States National Institutes of Healthabsorptionbasecomputational chemistrydesigndirect applicationdrug discoveryindexinginhibitor/antagonistlead optimizationnervous system disordernovelnovel therapeuticspre-clinicalprogramsscaffoldsmall moleculetherapeutic developmenttherapeutically effective
项目摘要
The National Institute on Neurological Disorders and Stroke (NINDS) and the NIH Blueprint
Neurotherapeutics Network (BPN) http://neuroscienceblueprint.nih.gov/bpdrugs/index.htm have a need
for the Medicinal Chemistry Support Program (MCSP) to provide a full-service facility and staff who would
support a medicinal chemistry discovery program beginning at the Exploratory Chemistry phase to
develop structure activity relationship (SAR) analysis and design, synthesis, in vitro absorption,
distribution, metabolism, excretion and toxicology (ADMET), computational chemistry/Computer Aided
Drug Discovery (CADD) and compound logistics of storage and shipping to support the Contributor
Mouradian/Disney (Rutgers/Scripps) to develop a novel therapeutic effective in Parkinson’s. This will be
achieved by advancing the SAR/SPR of their small molecule heterocyclic starting compound utilizing their
assays and in vitro ADMET to identify novel, selective inhibitors of the target enzyme that are directed at
Parkinson’s. Our drug discovery approach will be to synthesize novel ligands based on the heterocyclic
scaffold that are potent inhibitors. Candidate molecules will undergo profiling to assess criteria
specifically related to the physicochemical properties of compounds in a therapeutic setting, including
enzyme selectivity and tests to determine potential interactions with key metabolic enzyme systems. The
goal is to advance the project to go/no go decisions and to progress to each of the Option phases in
succession (start of Hit-to-Lead and start of Lead Optimization). The data generated from this contract
will be used by NINDS, contributors or sponsored investigators in support of Investigational New Drug
(IND) application directed preclinical activities. The results of the efforts of this contract will be the basis to
advance preclinical candidate compounds for further development i.e., advanced PK and toxicological
evaluation in preparation of IND filings.
The ultimate goal of the NIH programs served by this contract and of individual projects is to bring new
drugs to market. To this end, the NIH has been granted a Determination of Exceptional Circumstances
(DEC) to incorporate the Department of Health and Human Services Acquisition Regulation (HHSAR)
clauses at 352.227-11, Patent-Rights-Exceptional Circumstances and 352.227-14, Rights in Data –
Exceptional Circumstances, as part of any contract resulting from this solicitation. The HHSAR Clauses
will enable the Contributors to retain control of the intellectual property for compounds created through
the Medicinal Chemistry Support Program for Therapeutic Development (MCSP).
国家神经疾病和中风研究所(NINDS)和美国国立卫生研究院蓝图
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KEITH BARNES其他文献
KEITH BARNES的其他文献
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{{ truncateString('KEITH BARNES', 18)}}的其他基金
IGF::OT::IGF TASK ORDER NO. 0001 - MEDICINAL CHEMISTRY SUPPORT PROGRAM FOR THERAPEUTIC DEVELOPMENT (MCSP
IGF::OT::IGF 任务订单号
- 批准号:
10586014 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
GANESH (EMORY UNIVERSITY) - MCSP - HIT TO LEAD CHEMISTRY
GANESH(埃默里大学)- MCSP - 引领化学
- 批准号:
10881612 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
HIT TO LEAD CHEMISTRY UNDER PERFORMANCE AREA 2 OF ID/IQ CONTRACT NO. HHSN271201800001I
根据 ID/IQ 合同编号 2 的绩效领域 HIT 领导化学
- 批准号:
10719308 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
SHAMLOO (STANDFORD UNIVERSITY) - MCSP-EXPLORATORY CHEMISTRY (EC)
SHAMLOO(斯坦福大学)- MCSP-探索化学(EC)
- 批准号:
10720930 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
SHAMLOO (STANDFORD UNIVERSITY) - MCSP-EXPLORATORY CHEMISTRY (EC)
SHAMLOO(斯坦福大学)- MCSP-探索化学(EC)
- 批准号:
10938120 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
GANESH (EMORY UNIVERSITY) - MCSP - HIT TO LEAD CHEMISTRY
GANESH(埃默里大学)- MCSP - 引领化学
- 批准号:
10719283 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
AL-ALI (UNIVERSITY OF MIAMI, SCHOOL OF MEDICINE) - MCSP - EXPLORATORY CHEMISTRY (EC)
AL-ALI(迈阿密大学医学院)- MCSP - 探索化学 (EC)
- 批准号:
10719110 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
AL-ALI (UNIVERSITY OF MIAMI, SCHOOL OF MEDICINE) - MCSP - EXPLORATORY CHEMISTRY (EC)
AL-ALI(迈阿密大学医学院)- MCSP - 探索化学 (EC)
- 批准号:
10788086 - 财政年份:2022
- 资助金额:
$ 33.73万 - 项目类别:
IGF::OT::IGF TASK ORDER NO. 0001 - MEDICINAL CHEMISTRY SUPPORT PROGRAM FOR THERAPEUTIC DEVELOPMENT (MCSP
IGF::OT::IGF 任务订单号
- 批准号:
10373911 - 财政年份:2021
- 资助金额:
$ 33.73万 - 项目类别:
MCSP TORFP NO. NIH-NINDS-20-03: KATRITCH (USC) - BASE EC (PAIN)
MCSP TORFP 编号
- 批准号:
10285409 - 财政年份:2020
- 资助金额:
$ 33.73万 - 项目类别:
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