The Harvard Clinical and Translational Science Center

哈佛临床与转化科学中心

• 批准号: 10457151
• 负责人: Lee Marshall Nadler
• 金额: $ 19.18万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10457151
• 关键词: Address; Agreement; Attention; Biological Sciences; Center for Translational Science Activities; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Competence; Complex; Conceptions; Data; Data Set; Development; Diagnosis; Discipline; Eagles; Ecosystem; Electronic Health Record; Ensure; Evaluation; Evolution; Faculty; Fostering; Future; Goals; Grant; Health; Health Sciences; Healthcare; Human; Incentives; Individual; Informatics; Infrastructure; Institutional Review Boards; Knowledge; Learning; Longevity; Medical Students; Methodology; Methods; Mission; Ohio; Oregon; Patients; Performance; Population; Process; Research Methodology; Research Personnel; Resources; Risk; Schedule; Schools; Science; Special Population; Speed; Sum; System; Talents; Technology; Training; Training Support; Translational Research; Translations; Universities; Workforce Development; catalyst; clinical translation; cohort; education resources; evidence base; experimental study; graduate student; improved; informatics infrastructure; innovation; member; multidisciplinary; new technology; next generation; open innovation; open source; prevent; research study; skills; success; systems research; tool; translational research program

Contact PD/PI: Nadler, Lee Marshall OVERALL: ABSTRACT By convening, connecting, and catalyzing the formation of multi-institutional, cross-disciplinary teams from across Harvard's (HU) 10 schools and 16 independent academic health centers (AHCs), Harvard Catalyst (HC) has fostered a “One Harvard” community and culture that has transformed the quality, efficiency, and impact of clinical and translation (CT) research at HU. HC's commitment to make the whole of the HU CT research enterprise greater than the sum of its parts has led to the development and continuous evolution of 12 innovative and integrated Cores focused on training the 21st century CT workforce, addressing the needs of patients and their communities, and incentivizing and prioritizing collaboration, team science, and stakeholder engagement. HC Cores have developed workflows, processes, methodologies, tools, and technologies to support the training and needs of T0-T4 CT investigators, their teams, community stakeholders, and the HU ecosystem, and have collected qualitative and quantitative data to demonstrate their value at HU hub. Once demonstrated, HC shares its learning as open source with other CTSAs and the CTSA consortium. To date, Profiles, i2b2 SHRINE (now Accrual to Clinical Trials ACT Network), Master Reliance Agreements and online reliance systems (now SMART IRB), eagle-i, Scheduler, online educational resources (initiating the N-lighten Network), and open innovation experiments have been disseminated to the CTSA consortium. Going forward to fully align with NCATS' strategic goals, HC will implement five specific aims: Workforce Development (Aim 1) will support the broadly defined educational needs of the present and future CT workforce inclusive of all CT research domains, disciplines, medical and graduate students, post-graduate trainees, investigators, multi-disciplinary team members, and communities of collaborators. Research Methods and Processes (Aim 2) will provide “everything necessary” to execute CT research including methods, processes, workflows, pilot grants, novel technologies, and integrated data sets necessary for investigators and their teams to succeed locally and in collaboration with communities and the CTSA consortium. Integration (Aim 3) will ensure that translational science is interconnected across all T domains and is inclusive of the needs of special populations and individuals across their entire lifespan. Collaboration and Engagement (Aim 4) will promote team science by extending the CT research community beyond its traditional academic borders. It engages and partners with our patients, communities, and our diverse ecosystem to participate in prioritization decisions and gap analysis. Informatics (Aim 5) will respond to the needs of CT investigators, teams, patients, and communities by providing enabling processes, methodologies, and tools. HC Learning CT Research System will enable HC to study the science of CT science and develop evidence-based strategies to improve the conduct of CT research thereby increasing its impact on human health. HC will continue to share all resources developed and lessons learned with the CTSA consortium. Project Summary/Abstract Page 362 Contact PD/PI: Nadler, Lee Marshall Harvard Catalyst | The Harvard Clinical and Translational Science Center, connects, convenes, and catalyzes the faculty, trainees, and teams from across Harvard's 10 Schools and 16 Academic Healthcare Center to partner with its communities and biomedical ecosystem to address NCATS' five strategic goals to improve health.

联系PD/PI：Nadler、Lee马歇尔 总体：摘要 通过召集，连接和催化多机构，跨学科团队的形成， 在哈佛的10所学校和16个独立的学术健康中心（AHC），哈佛催化剂 (HC)培养了一个“一个哈佛”的社区和文化，改变了质量，效率， 临床和翻译（CT）研究在胡的影响。HC承诺让整个HU CT 研究企业大于其部分的总和，导致了发展和不断演变的 12个创新和综合的核心，专注于培训21世纪世纪的CT劳动力，满足 患者及其社区，激励和优先考虑协作、团队科学和利益相关者 订婚HC Cores开发了工作流程、流程、方法、工具和技术， 支持T0-T4 CT调查人员、他们的团队、社区利益相关者和HU的培训和需求 生态系统，并收集了定性和定量数据，以证明他们在HU枢纽的价值。一旦 HC与其他CTSA和CTSA联盟共享其开源学习。到目前为止， 简介、i2 b2 SHRINE（现为ACT临床试验网络的应计费用）、主信赖协议和在线 reliance系统（现在的SMART IRB）、eagle-i、earth、在线教育资源（启动N-lighten 网络）和开放式创新实验已经传播到CTSA财团。 为了与NCATS的战略目标完全一致，HC将实现五个具体目标： 发展（目标1）将支持当前和未来CT的广泛定义的教育需求 劳动力包括所有CT研究领域，学科，医学和研究生，研究生 学员、研究人员、多学科团队成员和合作者社区。研究方法 和过程（目标2）将提供“一切必要的”执行CT研究，包括方法， 流程、工作流程、试点赠款、新技术和研究人员所需的综合数据集 和他们的团队在当地取得成功，并与社区和CTSA联盟合作。一体化 (Aim 3）将确保翻译科学在所有T领域之间相互联系，并包括 特殊人群和个人在其整个生命周期的需求。合作与参与（目标 4)将通过将CT研究社区扩展到传统的学术领域来促进团队科学 边境它与我们的患者，社区和我们多样化的生态系统合作， 优先次序决定和差距分析。信息学（目标5）将满足CT研究者的需求， 通过提供支持流程、方法和工具，帮助团队、患者和社区。HC学习CT 研究系统将使HC能够研究CT科学，并制定基于证据的战略， 改善CT研究的开展，从而增加其对人类健康的影响。HC将继续分享 与CTSA联合体开发的所有资源和吸取的经验教训。 项目摘要/摘要第362页 联系PD/PI：Nadler、Lee马歇尔 哈佛催化剂|哈佛临床和转化科学中心，连接，召集和催化 来自哈佛10所学校和16个学术医疗中心的教师、学员和团队合作， 与其社区和生物医学生态系统，以解决NCATS的五个战略目标，以改善健康。