The Harvard Clinical and Translational Science Center

联系PD/PI：Nadler，Lee Matt 总体：摘要 通过召集、连接和催化多机构、跨学科团队的形成 在哈佛大学(HU)的10所学校和16个独立学术健康中心(AHC)上，哈佛大学催化剂 (Hc)培养了一个“同一哈佛”的社区和文化，改变了质量、效率和 临床和翻译(CT)研究在HU的影响。HC承诺使整个HU CT 研究企业大于其组成部分的总和，导致了 12个创新和集成的核心，专注于培训21世纪的CT员工，满足 患者及其社区，并激励和优先考虑协作、团队科学和利益相关者 订婚。HC核心开发了工作流程、流程、方法、工具和技术，以 支持T0-T4 CT调查员、他们的团队、社区利益相关者和HU的培训和需求 并收集了定性和定量的数据，以证明其在HU中心的价值。一次 在演示中，HC与其他CTSA和CTSA联盟分享了它作为开源的学习。到目前为止， 简介、i2b2 Shine(现已纳入临床试验ACT网络)、主依赖协议和在线 Reliance Systems(现在是SMART IRB)、Eagle-I、Scheduler、在线教育资源(启动N-Light 网络)，并向CTSA联盟传播了开放式创新实验。 展望未来，完全与NCATS的战略目标保持一致，HC将实施五个具体目标：劳动力 发展(目标1)将支持目前和未来CT的广泛定义的教育需求 包括所有CT研究领域、学科、医学和研究生、研究生的劳动力 实习生、调查人员、多学科团队成员和合作者社区。研究方法 和过程(目标2)将提供执行CT研究的“一切必要”，包括方法， 调查人员所需的流程、工作流程、试点拨款、新技术和综合数据集 以及他们的团队在当地并与社区和CTSA财团合作取得成功。整合 (目标3)将确保翻译科学跨所有T领域相互联系，并包括 特别人群和个人一生中的需要。协作和参与(AIM 4)将通过将CT研究社区扩展到其传统的学术之外来促进团队科学 边界。它与我们的患者、社区和我们不同的生态系统接触并合作，以参与 优先决策和差距分析。信息学(AIM 5)将响应CT调查人员的需求， 通过提供支持流程、方法和工具，为团队、患者和社区提供支持。HC学习CT 研究系统将使HC能够研究CT科学并制定循证战略，以 改进CT研究，从而增加其对人类健康的影响。HC将继续共享 与CTSA财团一起开发的所有资源和吸取的经验教训。 项目摘要/摘要页362 联系PD/PI：Nadler，Lee Matt 哈佛催化剂|哈佛临床和转化科学中心，连接、召集和催化 来自哈佛大学10所学院和16所学术医疗中心的教职员工、实习生和团队 与其社区和生物医学生态系统合作，以实现NCATS改善健康的五个战略目标。

Contact PD/PI: Nadler, Lee Marshall OVERALL: ABSTRACT By convening, connecting, and catalyzing the formation of multi-institutional, cross-disciplinary teams from across Harvard's (HU) 10 schools and 16 independent academic health centers (AHCs), Harvard Catalyst (HC) has fostered a “One Harvard” community and culture that has transformed the quality, efficiency, and impact of clinical and translation (CT) research at HU. HC's commitment to make the whole of the HU CT research enterprise greater than the sum of its parts has led to the development and continuous evolution of 12 innovative and integrated Cores focused on training the 21st century CT workforce, addressing the needs of patients and their communities, and incentivizing and prioritizing collaboration, team science, and stakeholder engagement. HC Cores have developed workflows, processes, methodologies, tools, and technologies to support the training and needs of T0-T4 CT investigators, their teams, community stakeholders, and the HU ecosystem, and have collected qualitative and quantitative data to demonstrate their value at HU hub. Once demonstrated, HC shares its learning as open source with other CTSAs and the CTSA consortium. To date, Profiles, i2b2 SHRINE (now Accrual to Clinical Trials ACT Network), Master Reliance Agreements and online reliance systems (now SMART IRB), eagle-i, Scheduler, online educational resources (initiating the N-lighten Network), and open innovation experiments have been disseminated to the CTSA consortium. Going forward to fully align with NCATS' strategic goals, HC will implement five specific aims: Workforce Development (Aim 1) will support the broadly defined educational needs of the present and future CT workforce inclusive of all CT research domains, disciplines, medical and graduate students, post-graduate trainees, investigators, multi-disciplinary team members, and communities of collaborators. Research Methods and Processes (Aim 2) will provide “everything necessary” to execute CT research including methods, processes, workflows, pilot grants, novel technologies, and integrated data sets necessary for investigators and their teams to succeed locally and in collaboration with communities and the CTSA consortium. Integration (Aim 3) will ensure that translational science is interconnected across all T domains and is inclusive of the needs of special populations and individuals across their entire lifespan. Collaboration and Engagement (Aim 4) will promote team science by extending the CT research community beyond its traditional academic borders. It engages and partners with our patients, communities, and our diverse ecosystem to participate in prioritization decisions and gap analysis. Informatics (Aim 5) will respond to the needs of CT investigators, teams, patients, and communities by providing enabling processes, methodologies, and tools. HC Learning CT Research System will enable HC to study the science of CT science and develop evidence-based strategies to improve the conduct of CT research thereby increasing its impact on human health. HC will continue to share all resources developed and lessons learned with the CTSA consortium. Project Summary/Abstract Page 362 Contact PD/PI: Nadler, Lee Marshall Harvard Catalyst | The Harvard Clinical and Translational Science Center, connects, convenes, and catalyzes the faculty, trainees, and teams from across Harvard's 10 Schools and 16 Academic Healthcare Center to partner with its communities and biomedical ecosystem to address NCATS' five strategic goals to improve health.