Harvard Clinical and Translational Science Center

项目摘要/摘要 哈佛大学的临床和转化性研究(CTR)在17个独立的地理位置上进行 分散的机构，包括哈佛医学院(HMS)，哈佛大学公共卫生学院， 和15个HMS附属的学术卫生保健中心。这些机构中的每一个在财政和运作上都是 独立拥有自己的管理、教员、IRB和电子健康记录。哈佛大学催化剂(哈佛大学) 作为CTR的唯一协调实体，并将这些机构聚集在一起，形成一个联合CTR 网络。自2008年以来，医委会已开发了大量的教育和CTR资源组合，以满足 哈佛大学CTR工作人员的需求，当他们的价值在哈佛大学得到证明时， 将它们分发给CTSA财团。展望未来，HC的总体愿景是与我们的 CTR工作人员、机构和社区将成为活的临床和翻译科学(CTS) 学习实验室。CTS学习实验室将不断评估和重新评估中心的CTR 优势和劣势，开发和实施提高效率的方案创新， CTR的质量、有效性和影响。使用CTS的原则和方法，并以 根据逻辑模型，HC致力于实现这些目标并克服翻译障碍。七 翻译障碍已被确定为可以缓解或克服的优先事项：1)教育资源 没有接触到所有学员，并且一直专注于调查人员，而不是调查团队；2) 广泛的研究资源往往是无形的，很难获得；3)大量的结构性和 监管障碍限制了跨机构合作；4)研究和临床数据需要连接 5)CTR工作人员不够多样化，必须在所有领域都有所发展； 6)不同人群获得和参与研究的机会有限；7)研究不足 存在支持将反恐审查证据付诸实践的机制。HC还将专注于更好的 了解和满足早期和代表不足的医学研究人员和他们的需求 团队，以及不同的患者群体和社区，同时努力使劳动力和 减少健康方面的不平等。提出了多项倡议，以实现五个具体目标：1)培训和多样化 CTR员工队伍；2)将学员和CTR团队与人力资源联系起来；3)与社区合作 利益相关者提高研究参与度；4)使卫生信息学民主化；5)使用CTS克服 严重的CTR路障。中心渴望向其他CTSA中心学习，并致力于传播和 在CTSA财团之间共享。从采用CTS方法中获得的见解将用于 克服翻译障碍，推进改善人类健康的集体国家目标。

PROJECT SUMMARY/ ABSTRACT Clinical and translational research (CTR) across Harvard is conducted at 17 independent and geographically dispersed institutions, including Harvard Medical School (HMS), Harvard T. H. Chan School of Public Health, and 15 HMS-affiliated academic health care centers. Each of these institutions is fiscally and operationally independent with their own governance, faculty, IRB, and electronic health records. Harvard Catalyst (HC) serves as the sole coordinating entity for CTR and has brought these institutions together as a federated CTR network. Since 2008, HC has developed a substantial portfolio of educational and CTR resources to meet the needs of the CTR workforce at Harvard and, when their value has been demonstrated at Harvard, disseminated them to the CTSA consortium. Moving forward, HC’s overarching vision is to partner with our CTR workforce, institutions, and communities to become a living clinical and translational science (CTS) learning laboratory. The CTS learning laboratory will continuously assess and reassess the hub’s CTR strengths and weaknesses, developing and implementing programmatic innovations to improve the efficiency, quality, effectiveness, and impact of CTR. Using the principles and methodologies of CTS and guided by a logic model, HC is committed to achieving these goals and overcoming translational roadblocks. Seven translational roadblocks have been prioritized that can be mitigated or overcome: 1) educational resources are not reaching all learners and have been focused on investigators, rather than investigational teams; 2) extensive research resources are frequently invisible and difficult to access; 3) substantial structural and regulatory barriers limit cross-institutional collaborations; 4) research and clinical data need to be connected and their access democratized; 5) CTR workforce is not sufficiently diverse and must be grown in all domains; 6) there is limited access to and participation by diverse populations in research; and 7) insufficient mechanisms exist to support implementation of CTR evidence into practice. HC will also focus on better understanding and meeting the needs of early-stage and underrepresented in medicine investigators and their teams, as well as diverse patient populations and communities, while working to diversify the workforce and reduce health inequities. Multiple initiatives are proposed to address five specific aims: 1) train and diversify the CTR workforce; 2) connect trainees and CTR teams with HC resources; 3) partner with community stakeholders to improve research participation; 4) democratize health informatics; and 5) use CTS to overcome significant CTR roadblocks. HC is eager to learn from other CTSA hubs and is committed to dissemination and sharing across the CTSA consortium. The insights derived from employing CTS approaches will be used to overcome translational roadblocks and advance the collective national goal of improving human health.