Pathology Peer Review and Pathology Support for the DNTP and DIR at NIEHS (EPL)

建立受试者合同是为了提供广泛的常规和专业病理学服务，以支持国家毒理学计划（NTP）根据合同开展的研究，并对这些研究生成的病理学标本进行补充研究。该合同还为NIEHS内部研究人员进行的研究和其他NIEHS合同研究提供关键病理学（包括分子病理学）支持。具体而言，本合同支持以下服务：1）尸检和内部尸检协助; 2）组织学（组织修剪和处理、载玻片制备和染色）; 3）组织病理学评价/解释; 4）应用专门的定性和定量形态学程序（免疫组织化学、形态计量学、细胞增殖、凋亡、电子显微镜）; 5）适应，发展，完善，应用细胞和分子生物学新技术，包括（但不限于）基因分型、DNA测序、原位杂交、DNA和RNA分离和扩增、以及真实的实时定量和原位PCR，以及这些技术应用的培训; 6）病理学同行评议（包括病理学数据审查[PDR]、病理学标本稽查[APS]、病理学评价的质量评估和病理学工作组协调[QA/PWG]）以及这些活动的技术支持; 7）病理学数据录入; 8）病理学数据或技术的介绍或出版，或对这些活动的支持; 9）现场病理学支持，以及10）对临床病理学组的支持（数据审查，数据存档）。在过去一年中，国家毒理学计划和NIEHS就该合同完成了以下工作：6项QA/PWG; 2项APS审查，1项尸检，2项组织学项目，对NIEHS内部项目的6项研究进行病理学评价，编写6份海报或期刊出版物。此外，还有许多其他的NTP和NIEHS项目正在进行中。现场病理学家参与了许多PWG，并监督了许多研究的病理学同行评审。其中一人对NTP非肿瘤性病变图谱做出了贡献，另一人领导或促成了许多分子病理学项目。对于临床病理学组，已对216项研究进行了质量控制审查或数据存档。执行此工作的人员还在数据协调单元中支持NTP，并管理许多NTP项目的数据。

The subject contract was established to provide a broad range of routine and specialized pathology services in support of studies conducted under contract by the National Toxicology Program (NTP) and for supplemental studies on pathology specimens generated through these studies. The contract also provides critical pathology (including molecular pathology) support for studies conducted by in-house investigators at NIEHS and other NIEHS contract studies. Specifically, the following services are supported by this contract: 1) necropsy and in-house necropsy assistance; 2) histology (tissue trimming and processing, slide preparation, and staining); 3) histopathological evaluation/interpretation; 4) application of specialized qualitative and quantitative morphological procedures (immunohistochemistry, morphometrics, cell proliferation, apoptosis, electron microscopy); 5) adaptation, development, refinement, application of new techniques in cellular and molecular biology including (but not limited to) genotyping, DNA sequencing, in situ hybridization, DNA and RNA isolation and amplification, and real time, quantitative, and in situ PCR, as well as training in the application of these techniques; 6) Pathology Peer Review (including Pathology Data Review [PDR], Audit of Pathology Specimens [APS], Quality Assessment of pathology evaluations and Pathology Working Group Coordination [QA/PWG]) and technical support for these activities; 7) pathology data entry; 8) presentation or publication of pathology data or techniques, or support for these activities; 9) on-site pathology support, and 10) support for the clinical pathology group (data review, data archiving). The following work was completed for the National Toxicology Program and the NIEHS on this contract in the past year: six QA/PWGs; 2 APS reviews, 1 necropsy, 2 histology projects, pathological evaluation of 6 studies for in-house NIEHS projects, preparation of 6 posters or journal publications. In addition, there are many other projects for the NTP and NIEHS that are in progress. The on-site pathologists have participated in numerous PWGs and oversaw the pathology peer review for numerous studies. One has contributed to the to the NTP Nonneoplastic Lesion Atlas, and one has lead or contributed to numerous molecular pathology projects. For the clinical pathology group, quality control review or data archiving has been performed for 216 studies. The person performing this work also supports NTP in the data coordination unit and manages data for numerous NTP projects.