IGF::OT::IGF "Pathology Peer Review and Pathology Support for the DNTP and DIR at NIEHS" Experimental Pathology Laboratories (EPL); FY15 funding to fund the base contract award; CAN 8010787

IGF::OT::IGF“NIEHS 的 DNTP 和 DIR 的病理学同行评审和病理学支持”实验病理学实验室 (EPL)；

• 批准号: 9323990
• 负责人: RODNEY MILLER
• 金额: $ 413.34万
• 依托单位: EXPERIMENTAL PATHOLOGY LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-28 至 2017-07-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9323990
• 关键词: Adverse effects; Apoptosis; Atlases; Autopsy; Award; Cancer Etiology; Cell Proliferation; Chemicals; Clinical Pathology; Consult; Contracts; DNA; DNA Sequence; Data; Development; Electron Microscopy; Ensure; Environmental Exposure; Evaluation; Experimental Pathology; Exposure to; Funding; Genotype; Goals; Government; Hazard Identification; Histology; Housing; Immunohistochemistry; In Situ; In Situ Hybridization; Journals; Laboratories; Lead; Lesion; Manuscripts; Molecular Biology; Molecular and Cellular Biology; National Institute of Environmental Health Sciences; National Toxicology Program; Pathologist; Pathology; Peer Review; Persons; Preparation; Procedures; Process; Public Health; Publications; Quality Control; RNA; Reporting; Research Design; Research Personnel; Services; Site; Slide; Specimen; Staging; Staining method; Stains; Support Contracts; Techniques; Time; Tissues; Toxic effect; Training; Work; base; carcinogenicity; data archive; developmental toxicity; disorder prevention; immunotoxicity; molecular pathology; posters; reproductive toxicity; research study; technical report; working group

The subject contract was established to provide a broad range of routine and specialized pathology services in support of studies conducted under contract by the National Toxicology Program (NTP) and for supplemental studies on pathology specimens generated through these studies. The contract also provides critical pathology (including molecular pathology) support for studies conducted by in-house investigators at NIEHS and other NIEHS contract studies. Specifically, the following services are supported by this contract: 1) necropsy and in-house necropsy assistance; 2) histology (tissue trimming and processing, slide preparation, and staining); 3) histopathological evaluation/interpretation; 4) application of specialized qualitative and quantitative morphological procedures (immunohistochemistry, morphometrics, cell proliferation, apoptosis, electron microscopy); 5) adaptation, development, refinement, application of new techniques in cellular and molecular biology including (but not limited to) genotyping, DNA sequencing, in situ hybridization, DNA and RNA isolation and amplification, and real time, quantitative, and in situ PCR, as well as training in the application of these techniques; 6) Pathology Peer Review (including Pathology Data Review [PDR], Audit of Pathology Specimens [APS], Quality Assessment of pathology evaluations and Pathology Working Group Coordination [QA/PWG]) and technical support for these activities; 7) pathology data entry; 8) presentation or publication of pathology data or techniques, or support for these activities; 9) on-site pathology support, and 10) support for the clinical pathology group (data review, data archiving). The following work was completed for the National Toxicology Program and the NIEHS on this contract in the past year: six QA/PWGs; 2 APS reviews, 1 necropsy, 2 histology projects, pathological evaluation of 6 studies for in-house NIEHS projects, preparation of 6 posters or journal publications. In addition, there are many other projects for the NTP and NIEHS that are in progress. The on-site pathologists have participated in numerous PWGs and oversaw the pathology peer review for numerous studies. One has contributed to the to the NTP Nonneoplastic Lesion Atlas, and one has lead or contributed to numerous molecular pathology projects. For the clinical pathology group, quality control review or data archiving has been performed for 216 studies. The person performing this work also supports NTP in the data coordination unit and manages data for numerous NTP projects.

主题合同的设立是为了提供广泛的常规和专门的病理学服务，以支持国家毒理学计划(NTP)根据合同进行的研究，并对通过这些研究产生的病理标本进行补充研究。该合同还为NIEHS的内部研究人员进行的研究和其他NIEHS合同研究提供关键病理学(包括分子病理学)支持。具体地说，本合同支持以下服务：1)尸检和内部尸检协助；2)组织学(组织剪裁和处理、切片准备和染色)；3)组织病理学评估/解释；4)专门的定性和定量形态程序的应用(免疫组织化学、形态计量学、细胞增殖、细胞凋亡、电子显微镜)；5)适应、开发、改进、应用细胞和分子生物学的新技术，包括(但不限于)基因分型、DNA测序、原位杂交、DNA和RNA分离和扩增，以及实时、定量和原位聚合酶链式反应，以及应用这些技术的培训；6)病理同行评审(包括病理数据评审[PDR]、病理标本审核[APS]、病理评估质量评估和病理工作组协调[QA/PWG])和对这些活动的技术支持；7)病理数据输入；8)介绍或发布病理数据或技术，或对这些活动提供支持；9)现场病理学支持，以及10)对临床病理小组的支持(数据评审、数据存档)。在过去的一年里，国家毒理学计划和NIEHS在这份合同上完成了以下工作：6个QA/PWG；2个APS审查，1个尸检，2个组织学项目，6个内部NIEHS项目的病理评估，准备6个海报或期刊出版物。此外，NTP和NIEHS还有许多其他项目正在进行中。现场病理学家参与了许多PWG，并监督了许多研究的病理学同行审查。其中一人对NTP非肿瘤性病变图集做出了贡献，另一人领导或参与了许多分子病理学项目。对于临床病理学组，进行了216项研究的质量控制回顾或数据存档。执行这项工作的人员还在数据协调单位为NTP提供支持，并管理许多NTP项目的数据。