Core F -Clinical Science Core

核心F：项目摘要/摘要。临床科学核心为临床提供支持， 在涉及人类受试者的艾滋病毒相关研究中的基础/翻译和行为调查人员 在加州大学洛杉矶分校(UCLA)、查尔斯·德鲁大学(CDU)及其附属中心。这个 核心F的目标是支持将初步和临床前的数据和想法转化为临床/人类 促进艾滋病毒科学并导致对艾滋病毒产生潜在可量化影响的干预措施的研究 流行病。核心将通过减少开发和实施Patient- 以研究为导向。核心有两个具体目标：1.为调查人员提供支持和培训 生物医学、行为和基础翻译患者的监管批准和实施方面- 面向艾滋病毒的研究；和2.通过增加研究机会，促进以病人为导向的艾滋病毒研究 参与者，并产生新的协作和概念。核心提供了简化的流程和 提供咨询服务，以缩短项目构思和筹资之间的时间(支持临床方案 成功提交赠款的开发和可行性评估)；减少资金和资金之间的时间 启动和完成研究；培训和支持新的调查人员和现有的调查人员 在人类受试者研究的监管、设计和实施方面，对以患者为中心的研究是新的， 将新颖有效的干预措施从实验室转移到临床(国内和全球)；支持 通过增加人类样本的获取而导致临床干预的机械性工作；促进 通过与艾滋病毒研究网络和数据的联系进行协作；并让代表不足的人群参与 通过研究研究志愿者项目(RSVP)进行艾滋病毒研究，这是一个由核心赞助的志愿者登记 艾滋病毒携带者和非艾滋病毒携带者有兴趣参与艾滋病毒相关研究，以产生最大 在重点人群中开展信息丰富的预防和治疗研究。核心的所有服务将同时支持 基于国内和国际的研究倡议。

CORE F: PROJECT SUMMARY/ABSTRACT. The Clinical Science Core provides support for clinical, basic/translational, and behavioral investigators in the conduct of HIV-related research involving human subjects at the University of California, Los Angeles (UCLA), Charles Drew University (CDU), and affiliated centers. The goal of Core F is to support the translation of preliminary and pre-clinical data and ideas into clinical/human studies that advance HIV science and lead to interventions with potential quantifiable impact on the HIV epidemic. The Core will do this by reducing identified barriers to the development and implementation of patient- oriented research. The Core has two Specific Aims: 1. To provide support and training to investigators in the regulatory approval and implementation aspects of biomedical, behavioral, and basic translational patient- oriented research in HIV, and 2. To facilitate patient-oriented research in HIV by increasing access to research participants and generating new collaborations and concepts. The Core offers a streamlined process and consultative services to reduce the time between project conception and funding (supporting clinical protocol development and feasibility assessment for successful grant submissions); reduce the time between funding and the initiation and completion of the research; train and support new investigators and established investigators new to patient-oriented research in regulatory, design, and implementation aspects of human subjects research, to move novel and efficacious interventions from the lab to the clinic (domestically and globally); support mechanistic work that can lead to clinical interventions by increasing access to human samples; promote collaboration through linkage to HIV research networks and data; and engage underrepresented populations in HIV research through the Research Study Volunteer Project (RSVP), a Core-sponsored volunteer registry for individuals with and without HIV interested in participating in HIV-related research, to generate the most informative prevention and treatment studies in key populations. All services of the Core will support both domestic and internationally based research initiatives.