Core F -Clinical Science Core

核心F：项目总结/摘要。临床科学核心为临床， 基础/翻译和行为研究人员，从事涉及人类受试者的艾滋病毒相关研究 在加州大学、洛杉矶分校（UCLA）、查尔斯·德鲁大学（CDU）和附属中心。的 核心F的目标是支持将初步和临床前数据和想法转化为临床/人类 推进艾滋病毒科学并导致对艾滋病毒具有潜在可量化影响的干预措施的研究 疫情核心将通过减少已确定的障碍来实现这一目标， 导向研究。核心有两个具体目标：1。为研究人员提供支持和培训， 生物医学、行为学和基本转化患者的监管批准和实施方面， 艾滋病研究; 2。通过增加研究机会，促进面向患者的艾滋病毒研究 参与者，并产生新的合作和概念。核心提供了一个简化的过程， 咨询服务，以缩短项目构思和资助之间的时间（支持临床方案 开发和可行性评估成功的赠款提交）;减少资金和 研究的启动和完成;培训和支持新的研究者和现有的研究者 在人类受试者研究的监管、设计和实施方面， 将新颖有效的干预措施从实验室转移到临床（国内和全球）;支持 通过增加人类样本的获取，可以导致临床干预的机械工作;促进 通过与艾滋病毒研究网络和数据的联系开展合作;并让代表性不足的人口参与 通过研究志愿者项目（RSVP）进行艾滋病毒研究，这是一个核心赞助的志愿者登记处， 有兴趣参与艾滋病毒相关研究的艾滋病毒感染者和非艾滋病毒感染者， 在重点人群中开展信息丰富的预防和治疗研究。核心的所有服务都将支持 国内和国际研究计划。

CORE F: PROJECT SUMMARY/ABSTRACT. The Clinical Science Core provides support for clinical, basic/translational, and behavioral investigators in the conduct of HIV-related research involving human subjects at the University of California, Los Angeles (UCLA), Charles Drew University (CDU), and affiliated centers. The goal of Core F is to support the translation of preliminary and pre-clinical data and ideas into clinical/human studies that advance HIV science and lead to interventions with potential quantifiable impact on the HIV epidemic. The Core will do this by reducing identified barriers to the development and implementation of patient- oriented research. The Core has two Specific Aims: 1. To provide support and training to investigators in the regulatory approval and implementation aspects of biomedical, behavioral, and basic translational patient- oriented research in HIV, and 2. To facilitate patient-oriented research in HIV by increasing access to research participants and generating new collaborations and concepts. The Core offers a streamlined process and consultative services to reduce the time between project conception and funding (supporting clinical protocol development and feasibility assessment for successful grant submissions); reduce the time between funding and the initiation and completion of the research; train and support new investigators and established investigators new to patient-oriented research in regulatory, design, and implementation aspects of human subjects research, to move novel and efficacious interventions from the lab to the clinic (domestically and globally); support mechanistic work that can lead to clinical interventions by increasing access to human samples; promote collaboration through linkage to HIV research networks and data; and engage underrepresented populations in HIV research through the Research Study Volunteer Project (RSVP), a Core-sponsored volunteer registry for individuals with and without HIV interested in participating in HIV-related research, to generate the most informative prevention and treatment studies in key populations. All services of the Core will support both domestic and internationally based research initiatives.