UCLA-CDU CFAR

总体：项目摘要/摘要：此申请是对新的合作伙伴关系CFAR的重新提交 加州大学洛杉矶分校和基民盟之间。我们的首要目标是创建一个灵活的多机构基础设施， 促进公平，并将联系和支持与这两个机构有关联的调查人员，以推动关键的艾滋病毒 科学。加州大学洛杉矶分校-CDU CFAR将加强和放大现有研究活动的影响并启动 通过我们对三个主题的关注，在洛杉矶和全球范围内建立新的伙伴关系：我们将在 预防新的艾滋病毒感染(预防)，减少艾滋病毒携带者的发病率(治疗)和 制定根除战略(不含抗逆转录病毒药物的缓解)。这笔赠款将资助与艾滋病有关的活动和 加州大学洛杉矶分校、CDU和我们的附属机构(包括港湾-加州大学洛杉矶分校)的调查人员开展的项目 托兰斯的医疗中心；加州大学洛杉矶分校的护理诊所和退伍军人管理局大洛杉矶医疗系统 韦斯特伍德；西好莱坞的加州大学洛杉矶分校葡萄街诊所；以及德鲁关怀组织、基民盟推动联盟和 基民盟的马丁·路德·金绿洲诊所。这些设施是洛杉矶县艾滋病流行的起点， 最多的艾滋病毒携带者居住在我们医院直接服务的社区 和诊所。除了洛杉矶的设施和项目外，加州大学洛杉矶分校和CDU的研究人员还 与全球各地旨在建设全球能力的艾滋病毒方案建立广泛的伙伴关系。CFAR 将通过接触最有需要的社区来增强我们在社区界面上交付研究的能力 通过利用CDU和加州大学洛杉矶分校的研究人员的才华来解决来自多学科的问题 同时指导下一代，更好地反映所服务社区的多样性。 加州大学洛杉矶分校-CDU CFAR的整体组织将使我们能够高效和有效地管理艾滋病 研究活动，利用我们的CFAR中的不同专业知识，并包括与社区的联系- 以临床医生研究人员和社区为基础。请求支持的第一年的行动计划包括 6个核心和1个科学工作组(SWG)：行政核心、发展核心、集中 实验室支持核心、人源化小鼠和基因治疗核心、社区参与和临床 信息学核心、临床科学核心和物质使用翻译研究。相关性： 需要对艾滋病毒疾病的发病机制、治疗和社会方面进行研究，才能结束这一流行病。 加州大学洛杉矶分校-CDU CFAR寻求通过提供连接基础设施来催化和扩大艾滋病毒研究， 支持和加强加州大学洛杉矶分校和基民盟的调查人员的能力。这将通过以下方式实现 鼓励开展和传播针对国立卫生研究院优先事项的影响大的多学科研究 预防新的艾滋病毒感染(预防)，减少艾滋病毒携带者的发病率(治疗)和 制定根除战略(不含抗逆转录病毒药物的缓解)。

Overall: Project Summary/Abstract: This application is a resubmission for a new CFAR that is a partnership between UCLA and CDU. Our overarching goal is to create a nimble multi-institutional infrastructure that promotes equity and will connect and support investigators affiliated with both institutions to advance critical HIV science. The UCLA-CDU CFAR will strengthen and amplify the impact of existing research activities and launch new partnerships across Los Angeles and globally through our focus on three themes: we will STOP HIV by preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission). This grant will fund AIDS-related activities and programs conducted by investigators at UCLA, CDU and our Affiliated institutions, which include Harbor-UCLA Medical Center in Torrance; the UCLA CARE Clinic and the VA Greater Los Angeles Healthcare System in Westwood; the UCLA Vine Street Clinic in West Hollywood; and the Drew CARES, the CDU PUSH coalition and the MLK OASIS Clinic at CDU. These facilities are at ground zero for the AIDS epidemic in Los Angeles County, with the greatest number of persons living with HIV residing in the neighborhoods directly served by our hospitals and clinics. In addition to the facilities and programs based in Los Angeles, researchers at UCLA and CDU have extensive partnerships with HIV programs around the globe that are aimed at building global capacity. The CFAR will enhance our ability to deliver research at the interface of community by reaching communities most in need and by bringing to bear the talent of CDU and UCLA researchers to address problems from a multi-disciplinary perspective while mentoring the next generation who better reflect the diversity of communities being served. The overall organization of the UCLA-CDU CFAR will allow us to efficiently and effectively manage AIDS research activities by harnessing the diverse expertise in our CFAR, and by including linkages to community- based clinician investigators and communities. The action plan for the first year of requested support includes 6 cores and 1 scientific working group (SWG): the Administrative Core, Developmental Core, Centralized Laboratory Support Core, Humanized Mouse and Gene Therapy Core, Community Engagement and Clinical Informatics Core, Clinical Science Core, and a Translational Research in Substance Use SWG. RELEVANCE: Research into the pathogenesis, treatment and social aspects of HIV disease is required to end the epidemic. The UCLA-CDU CFAR seeks to catalyze and expand HIV research by providing the infrastructure to connect, support and enhance the capacity of investigators affiliated with UCLA and CDU. This will be accomplished by stimulating the conduct and dissemination of high impact multidisciplinary research aimed at the NIH priorities of preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission).