AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
批准号:
10493539
负责人:
Judith S. Currier
金额:
$1000.0万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-09-01 至 2023-05-02
关键词:
AIDS clinical trial groupAIDS/HIV problemAddressAffectAgingAnti-Retroviral AgentsAntiviral AgentsAreaBehavioralBiological MarkersBloodCaliforniaCardiovascular systemClinicalClinical ResearchClinical TrialsCollaborationsCommunicationConduct Clinical TrialsDevelopmentDiseaseDisease remissionDrug resistance in tuberculosisEpidemicEvaluationFundingGoalsHIVHIV InfectionsHIV/TBHealthHepatitis BHepatitis B VirusImmuneImmunologicsIndustry CollaborationInfectionInfrastructureInternationalInterventionKnowledgeLaboratoriesLeadershipLos AngelesMaintenanceMental HealthMetabolicMorbidity - disease rateMultidrug-Resistant TuberculosisNeurologicObesityOccupational activity of managing financesPersonsPhasePopulationPreventionPrevention and Treatment of Opportunistic InfectionProtocols documentationPublishingRegimenResearchResearch PersonnelResourcesRiskScienceSpecimenSystemTestingTherapeuticTherapeutic InterventionTissuesTrainingTuberculosisUniversitiesVirus Diseasesactive methodacute infectionantiretroviral therapyburden of illnesschronic infectioncollaboratorycommunity engagementcommunity involvementcomorbiditycomparative efficacydata managementdesigndrug-sensitiveefficacy trialimprovedinnovationmortalitymultidisciplinaryneutralizing antibodynoveloperationpreventprotocol developmentsocialstatisticstherapeutic vaccinetreatment guidelines
中文摘要
项目总结
英文摘要
Project Summary
The AIDS Clinical Trials Group (ACTG) has been at the forefront of clinical research to advance HIV
therapeutics and improve the health of people living with HIV/AIDS for 30 years. Rigorous scientific research
conducted by the ACTG has laid the cornerstones for current HIV treatment guidelines. In this application for
the competitive renewal of the ACTG we propose a transformative research agenda that draws on an
international consortium of leading clinical and laboratory HIV investigators in collaboration with a world-class
Statistics and Data Management Center to design and conduct innovative interventional clinical trials that will
significantly reduce the global burden of disease due to HIV, TB and hepatitis B.
The Leadership and Operations Center (LOC) provides scientific leadership and fiscal and organizational
management of the ACTG. The ACTG Executive Committee (AEC) will serve as the overarching governing
body of the network. The AEC is guided by an Executive Management Committee that includes the Network
Chairs, Chief Quality Officer and the Chairs of the Laboratory and Statistical and Data Management Centers.
Transformative Science Groups will oversee the development and execution of the ACTG research agenda,
which will be coordinated and prioritized by the Scientific Agenda Steering Committee (SASC). Protocol
development, implementation, training and network evaluation will be facilitated by the Network Clinical Core at
Social & Scientific Systems, Inc. The LOC financial management group (Admin Core) at the University of
California, Los Angeles will oversee resource management and protocol fund distribution at the direction of the
AEC. The LOC will assure the engagement of Community in all aspects of the ACTG, and will coordinate
communication between all three components of the network. Specific aims of this proposal include: 1) Identify
interventions to reduce HIV reservoirs and control HIV replication in the absence of ART; 2) Test novel and
durable interventions targeting HIV infection; 3) Improve the treatment and prevention of drug sensitive and drug
resistant tuberculosis; 4) Prevent or improve the treatment of HIV-related non-infectious co-morbidities and
evaluate strategies to cure hepatitis B virus infection in people with and without HIV.
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AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
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批准号:10812944
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项目类别:
-
资助金额:$7622.26万
-
财政年份:2023
-
负责人:Judith S. Currier
-
依托单位:
CoVPN 3008 A Phase 3, Multi-Center, Randomized, Efficacy Study of COVID-19 mRNA Vaccine in Regions with SARS-CoV-2 Variants of Concern
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批准号:10493538
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项目类别:
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资助金额:$700.7万
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财政年份:2022
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负责人:Judith S. Currier
-
依托单位:
UCLA-CDU CFAR
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批准号:10874086
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项目类别:
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资助金额:$52.77万
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财政年份:2022
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负责人:Judith S. Currier
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依托单位:
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/
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批准号:10594377
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项目类别:
-
资助金额:$7150.0万
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财政年份:2022
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负责人:Judith S. Currier
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依托单位:
UCLA-CDU CFAR
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批准号:10609762
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项目类别:
-
资助金额:$320.95万
-
财政年份:2022
-
负责人:Judith S. Currier
-
依托单位:
UCLA-CDU CFAR
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批准号:10458369
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项目类别:
-
资助金额:$300.56万
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财政年份:2022
-
负责人:Judith S. Currier
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依托单位:
AIDS Clinical Trials Group for Research on Therapeutics for HIV and Related Infections
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批准号:10395059
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项目类别:
-
资助金额:$2056.64万
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财政年份:2021
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负责人:Judith S. Currier
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依托单位:
PPE Request
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批准号:10293979
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项目类别:
-
资助金额:$93.54万
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财政年份:2020
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负责人:Judith S. Currier
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依托单位:
Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/
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批准号:10182391
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项目类别:
-
资助金额:$18194.26万
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财政年份:2020
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负责人:Judith S. Currier
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依托单位:
UCLA AIDS Prevention and Treatment Clinical Trials Unit
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批准号:10166309
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项目类别:
-
资助金额:$30.0万
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财政年份:2020
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负责人:Judith S. Currier
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依托单位:
CoVPN 3502 / ACTIV-2/A5401
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批准号:10318831
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项目类别:
-
资助金额:$1980.75万
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财政年份:2020
-
负责人:Judith S. Currier
-
依托单位:
UCLA AIDS Prevention and Treatment Clinical Trials Unit
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批准号:8131292
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项目类别:
-
资助金额:$61.38万
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财政年份:2010
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负责人:Judith S. Currier
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依托单位:
PHASE II, RANDOMIZED, DOUBLE-BLIND STUDY OF THE SAFETY AND EFFICACY OF SCH 41
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批准号:7951538
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项目类别:
-
资助金额:$0.73万
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财政年份:2009
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负责人:Judith S. Currier
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依托单位:
A PHASE IV, PROSPECTIVE, RANDOMIZED, OPEN-LABEL EVALUATION OF THE EFFICACY OF
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批准号:7951540
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项目类别:
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资助金额:$1.62万
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财政年份:2009
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负责人:Judith S. Currier
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依托单位:
A PHASE II/III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF URIDINE
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批准号:7951562
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项目类别:
-
资助金额:$2.06万
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财政年份:2009
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负责人:Judith S. Currier
-
依托单位:
PHASE II, RANDOMIZED, DOUBLE-BLIND STUDY OF THE SAFETY AND EFFICACY OF SCH 41
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批准号:8167079
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项目类别:
-
资助金额:$0.45万
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财政年份:2009
-
负责人:Judith S. Currier
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依托单位:
A PHASE IV, PROSPECTIVE, RANDOMIZED, OPEN-LABEL EVALUATION OF THE EFFICACY OF
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批准号:8167080
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项目类别:
-
资助金额:$1.35万
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财政年份:2009
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负责人:Judith S. Currier
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依托单位:
UCLA AIDS Prevention and Treatment Clinical Trials Unit
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批准号:7920699
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项目类别:
-
资助金额:$197.04万
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财政年份:2009
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负责人:Judith S. Currier
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依托单位:
Prospective Evaluation of Antiviral Therapy and Cardiac Health
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批准号:7691228
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项目类别:
-
资助金额:$85.92万
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财政年份:2008
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负责人:Judith S. Currier
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依托单位:
Prospective Evaluation of Antiviral Therapy and Cardiac Health
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批准号:8112535
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项目类别:
-
资助金额:$80.18万
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财政年份:2008
-
负责人:Judith S. Currier
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依托单位: