Core C -Centralized Laboratory Support Core

核心C：项目摘要/摘要：加州大学洛杉矶分校-CDU艾滋病研究中心(CFAR)的一个主要重点是 促进多学科科学促进艾滋病毒预防、治疗和无抗逆转录病毒药物的研究 减刑。中央实验室支持核心职能为研究人员提供一站式中心 咨询并获得实验室分析、尖端技术和专业知识，以支持创新、 多学科研究。实验室服务包括以病毒学、免疫学和“组学”为重点的分析。 包括微生物组在内的技术。此外，这个核心还提供了获取宝贵人类血液的新途径 粘膜标本。这些服务使人们能够及时和经济有效地获得这些检测和组织， 否则对许多CFAR调查人员来说是无法达到的。Core还将致力于开发新的分析方法 和研究工具，以回应其用户的科学兴趣。Core还将提供经过CAP/CLIA认证的 支持临床研究进展的实验室服务。最后，核心还将提供重要的 培训和教育服务，使CFAR社区了解最新技术和 具体支持向独立过渡的早期调查人员。具体地说，我们建议：1) 通过全面的实验室服务促进艾滋病毒/艾滋病的基础和转化性研究，以评估艾滋病毒- 1感染和免疫反应；2)在研究的设计、实施和分析方面提供专业知识 检查HIV-1和微生物组、代谢组或蛋白质组；3)支持艾滋病毒预防的临床研究， 通过CAP/CLIA认证的实验室服务进行治疗和不含ART的缓解；以及4)支持和刺激 通过在相关实验室提供指导、培训和教育计划进行艾滋病毒/艾滋病翻译研究 技巧。

Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free remission. The Centralized Laboratory Support Core functions to provide investigators with a one-stop center for consultation and access to laboratory assays, cutting-edge technologies, and expertise to support innovative, multidisciplinary research. Laboratory services include assays focused on virology, immunology, and `omics' technologies including microbiome. In addition, this Core provides novel access to valuable human blood and mucosal specimens. These services enable timely and cost-effective access to these assays and tissues, which would be otherwise unattainable for many CFAR investigators. The Core will also work to develop new assays and research tools in response to the scientific interests of its users. The Core will also offer CAP/CLIA-certified laboratory services to support advancement of clinical research. Finally, the Core will also provide important training and education services to keep the CFAR community up to date on the latest technologies and specifically support early stage investigators in the transition to independence. Specifically, we propose to: 1) Facilitate basic and translational HIV/AIDS research through comprehensive laboratory services to assess HIV- 1 infection and immune responses; 2) Provide expertise in the design, implementation, and analysis of studies examining HIV-1 and the microbiome, metabolome, or proteome; 3) Support clinical research on HIV prevention, treatment, and ART-free remission through CAP/CLIA-certified laboratory services; and 4) Support and stimulate translational HIV/AIDS research by providing mentoring, training, and education programs in relevant laboratory techniques.