Core C -Centralized Laboratory Support Core

核心C - 集中实验室支持核心

• 批准号: 10458372
• 负责人: Grace M Aldrovandi
• 金额: $ 18.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458372
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Bioinformatics; Biological Assay; Biological Markers; Blood; Blood Cells; CLIA certified; Clinical; Clinical Research; Communities; Computer Analysis; Consultations; DNA; Diagnostic; Disease remission; Education; Enzyme-Linked Immunosorbent Assay; Funding; Genome; Genomics; Goals; Grant; HIV; HIV-1; Human; Immune response; Immunoassay; Immunology; Immunology procedure; Infection; Interdisciplinary Study; Laboratories; Laboratory Study; Link; Los Angeles; Measurement; Mentors; Modeling; Mucous Membrane; Needs Assessment; Plasma; Proteome; Proteomics; Publications; RNA; Reporting; Research; Research Design; Research Personnel; Resources; Science; Scientist; Services; Shotguns; Specimen; Techniques; Technology; Time; Tissues; Training; Training and Education; Umbilical Cord Blood; Viral Load result; Work; complex data; cost effective; cytokine; design; innovation; interest; lectures; metabolome; metabolomics; metagenomic sequencing; microbiome; microbiome sequencing; multidisciplinary; new technology; next generation sequencing; novel; programs; response; tool; virology

Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free remission. The Centralized Laboratory Support Core functions to provide investigators with a one-stop center for consultation and access to laboratory assays, cutting-edge technologies, and expertise to support innovative, multidisciplinary research. Laboratory services include assays focused on virology, immunology, and `omics' technologies including microbiome. In addition, this Core provides novel access to valuable human blood and mucosal specimens. These services enable timely and cost-effective access to these assays and tissues, which would be otherwise unattainable for many CFAR investigators. The Core will also work to develop new assays and research tools in response to the scientific interests of its users. The Core will also offer CAP/CLIA-certified laboratory services to support advancement of clinical research. Finally, the Core will also provide important training and education services to keep the CFAR community up to date on the latest technologies and specifically support early stage investigators in the transition to independence. Specifically, we propose to: 1) Facilitate basic and translational HIV/AIDS research through comprehensive laboratory services to assess HIV- 1 infection and immune responses; 2) Provide expertise in the design, implementation, and analysis of studies examining HIV-1 and the microbiome, metabolome, or proteome; 3) Support clinical research on HIV prevention, treatment, and ART-free remission through CAP/CLIA-certified laboratory services; and 4) Support and stimulate translational HIV/AIDS research by providing mentoring, training, and education programs in relevant laboratory techniques.

核心C：项目摘要/摘要：UCLA-CDU艾滋病研究中心（CFAR）的一个主要研究重点是