Core C -Centralized Laboratory Support Core
Core C -Centralized Laboratory Support Core
批准号:
10458372
负责人:
Grace M Aldrovandi
金额:
$18.85万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-04-08 至 2027-03-31
关键词:
AIDS preventionAIDS/HIV problemAcquired Immunodeficiency SyndromeBioinformaticsBiological AssayBiological MarkersBloodBlood CellsCLIA certifiedClinicalClinical ResearchCommunitiesComputer AnalysisConsultationsDNADiagnosticDisease remissionEducationEnzyme-Linked Immunosorbent AssayFundingGenomeGenomicsGoalsGrantHIVHIV-1HumanImmune responseImmunoassayImmunologyImmunology procedureInfectionInterdisciplinary StudyLaboratoriesLaboratory StudyLinkLos AngelesMeasurementMentorsModelingMucous MembraneNeeds AssessmentPlasmaProteomeProteomicsPublicationsRNAReportingResearchResearch DesignResearch PersonnelResourcesScienceScientistServicesShotgunsSpecimenTechniquesTechnologyTimeTissuesTrainingTraining and EducationUmbilical Cord BloodViral Load resultWorkcomplex datacost effectivecytokinedesigninnovationinterestlecturesmetabolomemetabolomicsmetagenomic sequencingmicrobiomemicrobiome sequencingmultidisciplinarynew technologynext generation sequencingnovelprogramsresponsetoolvirology
中文摘要
核心 C:项目摘要/摘要:UCLA-CDU 艾滋病研究中心 (CFAR) 的主要关注点是
促进多学科科学推进艾滋病毒预防、治疗和非抗逆转录病毒疗法的研究
缓解。中央实验室支持核心功能为研究人员提供一站式中心
咨询和获得实验室分析、尖端技术和专业知识,以支持创新、
多学科研究。实验室服务包括专注于病毒学、免疫学和“组学”的检测
包括微生物组在内的技术。此外,该核心提供了获取宝贵人类血液和
粘膜标本。这些服务能够及时且经济高效地获取这些检测和组织,这
否则对于许多 CFAR 调查人员来说是无法实现的。核心还将致力于开发新的检测方法
和研究工具以满足用户的科学兴趣。核心还将提供 CAP/CLIA 认证
支持临床研究进展的实验室服务。最后,核心还将提供重要的
培训和教育服务,让 CFAR 社区了解最新技术和
特别支持早期调查人员向独立过渡。具体来说,我们建议:1)
通过全面的实验室服务来评估艾滋病毒/艾滋病的基础和转化研究
1 感染与免疫反应; 2) 提供研究设计、实施和分析方面的专业知识
检查 HIV-1 和微生物组、代谢组或蛋白质组; 3) 支持艾滋病毒预防的临床研究,
通过 CAP/CLIA 认证的实验室服务进行治疗和免 ART 缓解; 4)支持和激励
通过在相关实验室提供指导、培训和教育计划来开展艾滋病毒/艾滋病转化研究
技术。
英文摘要
Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is
facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free
remission. The Centralized Laboratory Support Core functions to provide investigators with a one-stop center for
consultation and access to laboratory assays, cutting-edge technologies, and expertise to support innovative,
multidisciplinary research. Laboratory services include assays focused on virology, immunology, and `omics'
technologies including microbiome. In addition, this Core provides novel access to valuable human blood and
mucosal specimens. These services enable timely and cost-effective access to these assays and tissues, which
would be otherwise unattainable for many CFAR investigators. The Core will also work to develop new assays
and research tools in response to the scientific interests of its users. The Core will also offer CAP/CLIA-certified
laboratory services to support advancement of clinical research. Finally, the Core will also provide important
training and education services to keep the CFAR community up to date on the latest technologies and
specifically support early stage investigators in the transition to independence. Specifically, we propose to: 1)
Facilitate basic and translational HIV/AIDS research through comprehensive laboratory services to assess HIV-
1 infection and immune responses; 2) Provide expertise in the design, implementation, and analysis of studies
examining HIV-1 and the microbiome, metabolome, or proteome; 3) Support clinical research on HIV prevention,
treatment, and ART-free remission through CAP/CLIA-certified laboratory services; and 4) Support and stimulate
translational HIV/AIDS research by providing mentoring, training, and education programs in relevant laboratory
techniques.
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专著(0)
科研奖励(0)
会议论文
Core C -Centralized Laboratory Support Core
-
批准号:10609765
-
项目类别:
-
资助金额:$19.0万
-
财政年份:2022
-
负责人:Grace M Aldrovandi
-
依托单位:
Study of Tecovirimat for Human Monkeypox Virus (STOMP)
-
批准号:10689623
-
项目类别:
-
资助金额:$588.21万
-
财政年份:2022
-
负责人:Grace M Aldrovandi
-
依托单位:
A5401 COVID Supplement
-
批准号:10203227
-
项目类别:
-
资助金额:$377.0万
-
财政年份:2020
-
负责人:Grace M Aldrovandi
-
依托单位:
Effects of Human Milk Oligosaccharides and Gut Microbiome on Growth and Morbidity in HIV-Exposed Uninfected Infants
-
批准号:9920737
-
项目类别:
-
资助金额:$70.86万
-
财政年份:2019
-
负责人:Grace M Aldrovandi
-
依托单位:
Effects of Human Milk Oligosaccharides and Gut Microbiome on Growth and Morbidity in HIV-Exposed Uninfected Infants
-
批准号:10610833
-
项目类别:
-
资助金额:$74.24万
-
财政年份:2019
-
负责人:Grace M Aldrovandi
-
依托单位:
Effects of Human Milk Oligosaccharides and Gut Microbiome on Growth and Morbidity in HIV-Exposed Uninfected Infants
-
批准号:10382305
-
项目类别:
-
资助金额:$69.71万
-
财政年份:2019
-
负责人:Grace M Aldrovandi
-
依托单位:
Maturation, Infectibility, and Trauma(MIT) Contributes to HIV Susceptibility in Adolescents
-
批准号:9245320
-
项目类别:
-
资助金额:$63.22万
-
财政年份:2017
-
负责人:Grace M Aldrovandi
-
依托单位:
International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Laboratory Center
-
批准号:9317270
-
项目类别:
-
资助金额:$178.08万
-
财政年份:2016
-
负责人:Grace M Aldrovandi
-
依托单位:
International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Laboratory Center
-
批准号:9188522
-
项目类别:
-
资助金额:$331.27万
-
财政年份:2016
-
负责人:Grace M Aldrovandi
-
依托单位:
International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network
-
批准号:9986166
-
项目类别:
-
资助金额:$354.89万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
AIDS Clinical Trial Group Laboratory Center
-
批准号:10306319
-
项目类别:
-
资助金额:$826.56万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network
-
批准号:10306320
-
项目类别:
-
资助金额:$366.44万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
LC - IMPAACT Leadership Group
-
批准号:8555005
-
项目类别:
-
资助金额:$269.3万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
AIDS Clinical Trial Group Laboratory Center
-
批准号:9984198
-
项目类别:
-
资助金额:$776.56万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
International Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network
-
批准号:10528459
-
项目类别:
-
资助金额:$453.49万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
AIDS Clinical Trial Group Laboratory Center
-
批准号:10527322
-
项目类别:
-
资助金额:$819.65万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
LC - IMPAACT Leadership Group
-
批准号:8975604
-
项目类别:
-
资助金额:$122.51万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
LC - IMPAACT Leadership Group
-
批准号:8782608
-
项目类别:
-
资助金额:$282.32万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
AIDS Clinical Trial Group Laboratory Center
-
批准号:10747032
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2014
-
负责人:Grace M Aldrovandi
-
依托单位:
Oral Transmission of HIV through Breastfeeding
-
批准号:8522669
-
项目类别:
-
资助金额:$19.32万
-
财政年份:2010
-
负责人:Grace M Aldrovandi
-
依托单位: