Core C -Centralized Laboratory Support Core

核心C - 集中实验室支持核心

• 批准号: 10609765
• 负责人: Grace M Aldrovandi
• 金额: $ 19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609765
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Bioinformatics; Biological Assay; Biological Markers; Blood; Blood Cells; CLIA certified; Clinical; Clinical Research; Communities; Computer Analysis; Consultations; DNA; Dedications; Diagnostic; Disease remission; Education; Enzyme-Linked Immunosorbent Assay; Funding; Genome; Genomics; Goals; Grant; HIV; HIV-1; HIV/AIDS; Human; Immune response; Immunoassay; Immunology; Immunology procedure; Infection; Interdisciplinary Study; Laboratories; Laboratory Study; Link; Los Angeles; Measurement; Mentors; Modeling; Mucous Membrane; Needs Assessment; Plasma; Proteome; Proteomics; Publications; RNA; Reporting; Research; Research Design; Research Personnel; Resources; Science; Scientist; Services; Shotguns; Specimen; Techniques; Technology; Tissues; Training; Training and Education; Umbilical Cord Blood; Viral Load result; Work; complex data; cost effective; cytokine; design; innovation; interest; lectures; metabolome; metabolomics; metagenomic sequencing; microbiome; microbiome sequencing; multidisciplinary; new technology; next generation sequencing; novel; programs; response; tool; virology

Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free remission. The Centralized Laboratory Support Core functions to provide investigators with a one-stop center for consultation and access to laboratory assays, cutting-edge technologies, and expertise to support innovative, multidisciplinary research. Laboratory services include assays focused on virology, immunology, and `omics' technologies including microbiome. In addition, this Core provides novel access to valuable human blood and mucosal specimens. These services enable timely and cost-effective access to these assays and tissues, which would be otherwise unattainable for many CFAR investigators. The Core will also work to develop new assays and research tools in response to the scientific interests of its users. The Core will also offer CAP/CLIA-certified laboratory services to support advancement of clinical research. Finally, the Core will also provide important training and education services to keep the CFAR community up to date on the latest technologies and specifically support early stage investigators in the transition to independence. Specifically, we propose to: 1) Facilitate basic and translational HIV/AIDS research through comprehensive laboratory services to assess HIV- 1 infection and immune responses; 2) Provide expertise in the design, implementation, and analysis of studies examining HIV-1 and the microbiome, metabolome, or proteome; 3) Support clinical research on HIV prevention, treatment, and ART-free remission through CAP/CLIA-certified laboratory services; and 4) Support and stimulate translational HIV/AIDS research by providing mentoring, training, and education programs in relevant laboratory techniques.

核心C：项目摘要/摘要：加州大学洛杉矶分校-CDU艾滋病研究中心（CFAR）的一个主要重点是 促进多学科科学促进艾滋病毒预防、治疗和无ART研究 缓解。集中实验室支持核心功能为研究者提供一站式中心， 咨询和获得实验室分析，尖端技术和专业知识，以支持创新， 多学科研究。实验室服务包括侧重于病毒学、免疫学和“组学”的分析 包括微生物组在内的技术。此外，该核心提供了获得宝贵人类血液的新途径， 粘膜标本。这些服务使人们能够及时、经济高效地获得这些化验和组织， 这对许多CFAR调查人员来说是无法实现的。核心还将致力于开发新的检测方法 和研究工具，以满足其用户的科学兴趣。核心还将提供CAP/CLIA认证 实验室服务，以支持临床研究的进步。最后，核心还将提供重要的 培训和教育服务，使CFAR社区了解最新技术， 特别是在向独立过渡的早期阶段为调查人员提供支助。具体而言，我们建议：1） 通过全面的实验室服务促进艾滋病毒/艾滋病的基础和转化研究，以评估艾滋病毒- 1感染和免疫反应; 2）提供研究设计，实施和分析方面的专业知识 检查HIV-1和微生物组、代谢组或蛋白质组; 3）支持HIV预防的临床研究， 通过CAP/CLIA认证的实验室服务进行无ART治疗和缓解;以及4）支持和激励 通过在相关实验室提供指导、培训和教育计划，开展转化型艾滋病毒/艾滋病研究 技术.