Core C -Centralized Laboratory Support Core

核心C - 集中实验室支持核心

• 批准号: 10609765
• 负责人: Grace M Aldrovandi
• 金额: $ 19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10609765
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Bioinformatics; Biological Assay; Biological Markers; Blood; Blood Cells; CLIA certified; Clinical; Clinical Research; Communities; Computer Analysis; Consultations; DNA; Dedications; Diagnostic; Disease remission; Education; Enzyme-Linked Immunosorbent Assay; Funding; Genome; Genomics; Goals; Grant; HIV; HIV-1; HIV/AIDS; Human; Immune response; Immunoassay; Immunology; Immunology procedure; Infection; Interdisciplinary Study; Laboratories; Laboratory Study; Link; Los Angeles; Measurement; Mentors; Modeling; Mucous Membrane; Needs Assessment; Plasma; Proteome; Proteomics; Publications; RNA; Reporting; Research; Research Design; Research Personnel; Resources; Science; Scientist; Services; Shotguns; Specimen; Techniques; Technology; Tissues; Training; Training and Education; Umbilical Cord Blood; Viral Load result; Work; complex data; cost effective; cytokine; design; innovation; interest; lectures; metabolome; metabolomics; metagenomic sequencing; microbiome; microbiome sequencing; multidisciplinary; new technology; next generation sequencing; novel; programs; response; tool; virology

Core C: Project Summary/Abstract: A major focus of the UCLA-CDU Center for AIDS Research (CFAR) is facilitation of multidisciplinary science to advance research in HIV prevention, treatment, and ART-free remission. The Centralized Laboratory Support Core functions to provide investigators with a one-stop center for consultation and access to laboratory assays, cutting-edge technologies, and expertise to support innovative, multidisciplinary research. Laboratory services include assays focused on virology, immunology, and `omics' technologies including microbiome. In addition, this Core provides novel access to valuable human blood and mucosal specimens. These services enable timely and cost-effective access to these assays and tissues, which would be otherwise unattainable for many CFAR investigators. The Core will also work to develop new assays and research tools in response to the scientific interests of its users. The Core will also offer CAP/CLIA-certified laboratory services to support advancement of clinical research. Finally, the Core will also provide important training and education services to keep the CFAR community up to date on the latest technologies and specifically support early stage investigators in the transition to independence. Specifically, we propose to: 1) Facilitate basic and translational HIV/AIDS research through comprehensive laboratory services to assess HIV- 1 infection and immune responses; 2) Provide expertise in the design, implementation, and analysis of studies examining HIV-1 and the microbiome, metabolome, or proteome; 3) Support clinical research on HIV prevention, treatment, and ART-free remission through CAP/CLIA-certified laboratory services; and 4) Support and stimulate translational HIV/AIDS research by providing mentoring, training, and education programs in relevant laboratory techniques.

核心 C：项目摘要/摘要：UCLA-CDU 艾滋病研究中心 (CFAR) 的主要关注点是 促进多学科科学推进艾滋病毒预防、治疗和非抗逆转录病毒疗法的研究 缓解。中央实验室支持核心功能为研究人员提供一站式中心 咨询和获得实验室分析、尖端技术和专业知识，以支持创新、 多学科研究。实验室服务包括专注于病毒学、免疫学和“组学”的检测 包括微生物组在内的技术。此外，该核心提供了获取宝贵人类血液和 粘膜标本。这些服务能够及时且经济高效地获取这些检测和组织，这 否则对于许多 CFAR 调查人员来说是无法实现的。核心还将致力于开发新的检测方法 和研究工具以满足用户的科学兴趣。核心还将提供 CAP/CLIA 认证 支持临床研究进展的实验室服务。最后，核心还将提供重要的 培训和教育服务，让 CFAR 社区了解最新技术和 特别支持早期调查人员向独立过渡。具体来说，我们建议：1） 通过全面的实验室服务来评估艾滋病毒/艾滋病的基础和转化研究 1 感染与免疫反应； 2) 提供研究设计、实施和分析方面的专业知识 检查 HIV-1 和微生物组、代谢组或蛋白质组； 3) 支持艾滋病毒预防的临床研究， 通过 CAP/CLIA 认证的实验室服务进行治疗和免 ART 缓解； 4）支持和激励 通过在相关实验室提供指导、培训和教育计划来开展艾滋病毒/艾滋病转化研究 技术。