Administrative Core

项目概要/摘要 行政核心 行政核心将监督整个方案的协调。具体而言，它将负责 监督组织结构和责任链。每周的实验室会议，每月的项目范围 会议、年度内部咨询委员会会议和年度外部咨询委员会会议将 通过这个核心进行协调和记录。核心还将协调年度演讲系列， 与咨询委员会会议同时举行。核心将维护记录，与NHLBI项目官员接口， 与FDA和IRB沟通，与DSMB沟通，并维护项目网站。芯会 确保组件项目和核心之间以及计划和其他相关项目之间的最佳交互 机构方案。核心将监督数据安全监控的适当和彻底执行 计划，并将致力于确保实现多样性目标。核心将确保适当传播信息 在项目期间获得的资源。核心将确保及时完成所有翻译里程碑， 使该计划能够为重度哮喘患者提供最佳临床获益。 第二百五十七页

PROJECT SUMMARY/ABSTRACT Administrative Core The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising the organizational structure and chain of responsibility. Weekly lab meetings, monthly program- wide meetings, annual internal advisory board meetings and annual external advisory board meetings will be coordinated and documented through this core. An annual speaker series will also be coordinated by the core, in conjunction with advisory board meetings. The core will maintain records, interface with the NHLBI Program Officer, interface with FDA and both IRB’s, interface with the DSMB, and maintain the Program’s web site. The core will ensure optimal interactions between component projects and cores, and between the program and other relevant institutional programs. The core will supervise the proper and thorough execution of the data safety monitoring plan, and will aim to ensure that diversity targets are met. The core will ensure proper dissemination of information and resources acquired during the project. The core will ensure timely completion of all translational milestones to enable the Program to have an optimal clinical benefit for patients with severe asthma. Page 257