A2CPS Administrative Core

行政核心 摘要 ODGC行政核心(ODGC)将负责促进A2CPS的总体目标 监督、协调和促进所有ODGC活动的计划。ODGC管理核心团队 将分成三个小组：领导，将由四个ODGC多项绩效指标组成；领域 在疼痛的临床、心理社会、生理和遗传方面具有专业知识的专家，翻译 研究慢性疼痛的治疗方法和神经成像；以及行政人员。领导班子已经 丰富的科学和项目领导经验：项目负责人有计算生物学背景， 他是计算生物学和生物信息学中心的主任 在她所在的机构；联合负责人是一名内科科学家，在细胞外RNA和干细胞生物学方面拥有专业知识 和基因组学，他曾担任美国国立卫生研究院共同基金联盟指导委员会的联合主席； CO-I是她所在机构基因组学中心的主任，该中心提供基因组学培训、咨询、 并为200多个实验室提供服务；另一位联合-I是基因组医学研究所所长和主任 在她所在的机构，CTSA生物计算中心的研究重点是了解基因 易患复杂疾病。行政核心的主要任务分为两个目标。 目标1侧重于发展伙伴关系内部管理，将包括建立基础设施，以 协调发展司内部常设会议和临时会议及电话会议，设定目标，监测进展情况， 分配资源，促进解决技术挑战，促进ODGC之间的科学交流 调查人员，解决纠纷，聘请顾问，准备NIH进度报告，维护监管 遵守，并规划和协调摘要和手稿的准备工作。《目标2》专注于 协调ODGC与A2CP的其他元素之间的交互，包括其他计划 中心、外部项目顾问和NIH项目工作人员。这些互动将包括讨论 导致：确定将包括在计划中的一套最终的基因组分析；选择 40个主要结果候选生物标记物：建立生物有机磷农药的标准操作程序 收集、处理和储存；开发样本和数据跟踪、记录 相关元数据，并将数据和元数据从ODGC转移到DIRC。ODGC管理 CORE还将建立知识产权协议，包括与材料和数据相关的协议 在ODGC核心/组件和其他A2CPS中心之间进行调拨，并组织旅行和酒店 为参加A2CPS计划面对面会议的ODGC人员提供住宿。行政管理的核心 组织结构将设计为提供领导、项目和数据管理，以及 行政支持将有助于ODGC和A2CPS计划作为一个整体的成功。

ADMINISTRATIVE CORE SUMMARY The ODGC Administrative Core (ODGC) will be responsible for promoting the overall goals of the A2CPS Program by supervising, coordinating, and facilitating all ODGC activities. The ODGC Administrative Core team will be organized into three groups: Leadership, which will be comprised of the four ODGC multi-PIs; Domain Experts with expertise in the clinical, psychosocial, physiological and genetic aspects of pain, translational research on therapies for chronic pain, and neuroimaging; and Administrative Staff. The Leadership team has strong scientific and project leadership experience: the Project Lead has a background in computational biology, population genetics and genomics, and is the Director of the Center for Computational Biology and Bioinformatics at her institution; the Co-Lead is a physician-scientist with expertise in extracellular RNA and stem cell biology and genomics who served as Co-Chair of the Steering Committee for a NIH Common Fund Consortium; one Co-I is the Director of the Genomics Center at her institution, which provides genomics training, consultation, and services to over 200 laboratories; the other Co-I is Director of the Institute for Genomic Medicine and Director of the Bio-Computational Center of the CTSA at her institution with a research focus on understanding genetic predisposition to complex diseases. The primary tasks of the Administrative Core are organized into two Aims. Aim 1, which concentrates on intra-ODGC management, will encompass establishment of infrastructure for coordinating intra-ODGC standing and ad hoc meetings and conference calls, setting goals, monitoring progress, allocating resources, facilitating resolution of technical challenges, promoting scientific exchange among ODGC investigators, resolving disputes, engaging consultants, preparing NIH progress reports, maintaining regulatory compliance, and planning and coordinating abstract and manuscript preparation. Aim 2 is focused on coordinating interactions between the ODGC and other elements of the A2CPS, including the other Program Centers, the External Program Consultants, and NIH Program Staff. These interactions will include discussions leading to: determination of the definitive set of omic assays that will be included in the Program; selection of the 40 primary outcome candidate biomarkers; establishment of Standard Operating Procedures for biospecimen collection, processing and storage; and development of systems for sample and data tracking, recording of relevant metadata, and transferring data and metadata from the ODGC to the DIRC. The ODGC Administrative Core will also establish intellectual property agreements, including those associated with materials and data transfer among ODGC Cores/Components and other A2CPS Centers, and organize travel and hotel accommodation of ODGC personnel for the A2CPS Program in-person meetings. The Adminstrative Core organizational structure will be designed to provide the leadership, project and data management, and administrative support that will contribute to the success of the ODGC and the A2CPS Program as a whole.