A2CPS Administrative Core

A2CPS 管理核心

• 批准号: 10457870
• 负责人: Kathleen Marie Fisch
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10457870
• 关键词: Acute; Agreement; Bioinformatics; Biological Assay; Clinical; Collaborations; Collection; Communication; Complex; Computational Biology; Consultations; Data; Data Coordinating Center; Disease; Disputes; Elements; Ensure; Funding; Generations; Genetic; Genetic Predisposition to Disease; Genomic medicine; Genomics; Goals; Human Resources; Infrastructure; Institutes; Institution; Institutional Review Boards; Intellectual Property; Laboratories; Lead; Leadership; Manuscripts; Metadata; Mission; Monitor; Office of Administrative Management; Pain; Participant; Persons; Physicians; Physiological; Policies; Population Genetics; Preparation; Procedures; Progress Reports; Proteomics; Protocols documentation; RNA; Research; Research Personnel; Resolution; Resources; Sampling; Scientist; Services; Supervision; System; Systems Development; Training; Transfer Agreement; Translational Research; Travel; United States National Institutes of Health; biocomputing; candidate marker; chronic pain; chronic pain management; data exchange; data integration; data management; design; experience; extracellular; genetic variant; lipidomics; meetings; metabolomics; neuroimaging; operation; organizational structure; primary outcome; programs; psychosocial; stem cell biology; success; symposium

ADMINISTRATIVE CORE SUMMARY The ODGC Administrative Core (ODGC) will be responsible for promoting the overall goals of the A2CPS Program by supervising, coordinating, and facilitating all ODGC activities. The ODGC Administrative Core team will be organized into three groups: Leadership, which will be comprised of the four ODGC multi-PIs; Domain Experts with expertise in the clinical, psychosocial, physiological and genetic aspects of pain, translational research on therapies for chronic pain, and neuroimaging; and Administrative Staff. The Leadership team has strong scientific and project leadership experience: the Project Lead has a background in computational biology, population genetics and genomics, and is the Director of the Center for Computational Biology and Bioinformatics at her institution; the Co-Lead is a physician-scientist with expertise in extracellular RNA and stem cell biology and genomics who served as Co-Chair of the Steering Committee for a NIH Common Fund Consortium; one Co-I is the Director of the Genomics Center at her institution, which provides genomics training, consultation, and services to over 200 laboratories; the other Co-I is Director of the Institute for Genomic Medicine and Director of the Bio-Computational Center of the CTSA at her institution with a research focus on understanding genetic predisposition to complex diseases. The primary tasks of the Administrative Core are organized into two Aims. Aim 1, which concentrates on intra-ODGC management, will encompass establishment of infrastructure for coordinating intra-ODGC standing and ad hoc meetings and conference calls, setting goals, monitoring progress, allocating resources, facilitating resolution of technical challenges, promoting scientific exchange among ODGC investigators, resolving disputes, engaging consultants, preparing NIH progress reports, maintaining regulatory compliance, and planning and coordinating abstract and manuscript preparation. Aim 2 is focused on coordinating interactions between the ODGC and other elements of the A2CPS, including the other Program Centers, the External Program Consultants, and NIH Program Staff. These interactions will include discussions leading to: determination of the definitive set of omic assays that will be included in the Program; selection of the 40 primary outcome candidate biomarkers; establishment of Standard Operating Procedures for biospecimen collection, processing and storage; and development of systems for sample and data tracking, recording of relevant metadata, and transferring data and metadata from the ODGC to the DIRC. The ODGC Administrative Core will also establish intellectual property agreements, including those associated with materials and data transfer among ODGC Cores/Components and other A2CPS Centers, and organize travel and hotel accommodation of ODGC personnel for the A2CPS Program in-person meetings. The Adminstrative Core organizational structure will be designed to provide the leadership, project and data management, and administrative support that will contribute to the success of the ODGC and the A2CPS Program as a whole.

行政核心 总结 ODGC行政核心（ODGC）将负责促进A2CPS的总体目标 通过监督，协调和促进所有ODGC活动进行计划。ODGC行政核心团队 将分为三个小组：领导小组，由四个ODGC多PI组成;领域 在疼痛的临床，心理，生理和遗传方面具有专业知识的专家，翻译 慢性疼痛治疗研究和神经影像学;以及行政人员。领导团队 强大的科学和项目领导经验：项目负责人具有计算生物学背景， 人口遗传学和基因组学，是计算生物学和生物信息学中心主任 在她的机构;共同负责人是一个医生，科学家与细胞外RNA和干细胞生物学的专业知识 和基因组学谁担任共同主席的指导委员会为美国国立卫生研究院共同基金财团; Co-I是她所在机构基因组学中心的主任，该中心提供基因组学培训、咨询， 并为200多个实验室提供服务;另一位Co-I是基因组医学研究所所长和 CTSA生物计算中心的研究重点是了解遗传 易患复杂疾病。行政核心的主要任务分为两个目标。 目标1侧重于毒品和犯罪问题办公室内部的管理，将包括建立基础设施， 协调毒品和犯罪问题办公室内部的常设和特别会议以及电话会议，制定目标，监测进展情况， 分配资源，促进解决技术挑战，促进ODGC之间的科学交流 调查人员，解决争议，聘请顾问，准备NIH进度报告，维护监管 合规性，计划和协调摘要和手稿的准备。目标2的重点是 协调作战指挥官办公室与A2CPS的其他组成部分（包括其他计划）之间的互动 中心，外部项目顾问和NIH项目工作人员。这些互动将包括讨论 导致：确定将包括在程序中的组学测定的确定集;选择 40个主要结局候选生物标志物;建立生物标本标准操作规程 收集、处理和储存;以及开发样品和数据跟踪、记录 相关元数据，以及将数据和元数据从ODGC传输到DIRC。ODGC行政 核心还将建立知识产权协议，包括与材料和数据有关的协议 在ODGC核心/组件和其他A2CPS中心之间转移，并组织旅行和酒店 ODGC人员的住宿A2CPS计划面对面会议。行政核心 组织结构的设计将提供领导、项目和数据管理， 行政支持，这将有助于ODGC和A2CPS计划作为一个整体的成功。