课题基金 / 基金详情

Center of Research on Obesity and Cardiovascular Disease

Center of Research on Obesity and Cardiovascular Disease
肥胖与心血管疾病研究中心
批准号:
10458562
负责人:
Lisa A Cassis
金额:
$114.75万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-08-01 至 2024-07-31

项目摘要

项目成果

Lisa A Cassis的其他基金

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相关文献

中文摘要
翻译
卓越生物医学研究中心(COBRE)关于肥胖和心血管疾病的第三期研究
英文摘要
Phase III of the Center for Biomedical Research Excellence (COBRE) on Obesity and Cardiovascular Diseases (COCVD) will further develop and expand upon obesity as an underlying risk factor for the development of cardiovascular diseases, type 2 diabetes, cancer and neurodegenerative diseases. Each of these diseases are rampant in Kentucky, and obesity has been identified as a contributing risk factor for each condition. For Phase III of the COCVD, we will transition the research core facilities developed during Phase I and II of this program to independence. We will also support pilot project studies that include obesity as a risk factor for disease development. We have experienced considerable success, having supported 23 junior investigators and 21 pilot project investigators who generated $52 million in extramural funding and published more than 500 scholarly publications. Collectively, our team has published more than 280 scholarly articles that directly cite COCVD support. We developed an analytical core that provides services in lipidomics and other small molecules, a pathology core that provides specialized services to quantify adipose and other tissue morphology, and an energy balance and body composition core that is not duplicated in capacity across the institution or the Commonwealth. During Phase III of the COCVD, we will transition each core to self- sustaining capacity and upgrade core equipment and use by continuing to provide high quality specialized services, and by expanding core capabilities through provision of additional services that relate obesity to other diseases (e.g., cancer). Transition to independence of COCVD cores will be facilitated by use of a voucher system to promote core use. We will also continue our strong tradition of pilot project funding, which will be expanded to include studies that focus on obesity as an underlying risk factor for not only cardiovascular diseases, but also type 2 diabetes, cancer and neurodegenerative diseases. These areas have been designated as areas of strength across the institution (as each disease is a health disparity experienced by Kentuckians), and are designated for growth within a new research facility that will focus on Kentucky's health disparities. The Administrative Core will oversee all administrative functions of the COCVD and in conjunction with the Program Coordinator and the Scientific Internal Advisory Committee will serve as the operational limb of the Center. An External Advisory Committee, composed of experts in related fields, will provide ongoing assessment and evaluation of the Center. Institutional commitment continues to be outstanding and is supplemented by strong evidence of programmatic growth of direct relevance to this Phase III COCVD.
期刊论文(51)
专著(0)
科研奖励(0)
会议论文
Monosomy X in Female Mice Influences the Regional Formation and Augments the Severity of Angiotensin II-Induced Aortopathies.
雌性小鼠的单肌X会影响区域形成,并增加血管紧张素II诱导的主动脉病的严重程度。
DOI: 10.1161/atvbaha.120.314407
发表时间: 2021-01
期刊: Arteriosclerosis, thrombosis, and vascular biology
影响因子: --
作者: [AlSiraj Y, Thatcher SE, Blalock E, Saintilnord WN, Daugherty A, Lu HS, Luo W, Shen YH, LeMaire SA, Arnold AP, Cassis LA]
通讯作者: Cassis LA
DOI: 10.1016/j.cjca.2021.03.021
发表时间: 2021-10
期刊: The Canadian journal of cardiology
影响因子: --
作者: [Luo T, Liu H, Chen B, Liu H, Abdel-Latif A, Kitakaze M, Wang X, Wu Y, Chou D, Kim JK]
通讯作者: Kim JK
DOI: 10.1161/atvbaha.120.315546
发表时间: 2021-05-05
期刊: Arteriosclerosis, thrombosis, and vascular biology
影响因子: --
作者: [Muniappan L, Okuyama M, Javidan A, Thiagarajan D, Jiang W, Moorleghen JJ, Yang L, Balakrishnan A, Howatt DA, Uchida HA, Saido TC, Subramanian V]
通讯作者: Subramanian V
De Novo Crohn's Disease Diagnosed in the Setting of Acute SARS-Cov-2 Infection Requiring Escalation of Infliximab Therapy Guided by Personalized Pharmacokinetics.
在急性 SARS-Cov-2 感染的情况下诊断出新发克罗恩病,需要在个性化药代动力学指导下升级英夫利昔单抗治疗。
DOI: 10.26502/jppch.74050172
发表时间: 2024
期刊: Journal of pediatrics, perinatology and child health
影响因子: --
作者: [Romo,MartinVarea, Acharya,Kishor, Shelman,NathanR, Minar,Phillip, Denson,LeeA, Softic,Samir]
通讯作者: Softic,Samir
24
    The serotonergic system in periaortic fat regulates regional aortopathy development
    • 批准号:
      10651042
    • 项目类别:
    • 资助金额:
      $59.52万
    • 财政年份:
      2023
    • 负责人:
      Lisa A Cassis
    • 依托单位:
    Administrative Core
    • 批准号:
      10458563
    • 项目类别:
    • 资助金额:
      $34.43万
    • 财政年份:
      2018
    • 负责人:
      Lisa A Cassis
    • 依托单位:
    Administrative Core
    • 批准号:
      10225370
    • 项目类别:
    • 资助金额:
      $34.43万
    • 财政年份:
      2018
    • 负责人:
      Lisa A Cassis
    • 依托单位:
    Center of Research on Obesity and Cardiovascular Disease
    • 批准号:
      9982352
    • 项目类别:
    • 资助金额:
      $114.75万
    • 财政年份:
      2018
    • 负责人:
      Lisa A Cassis
    • 依托单位:
    海外基金