ERC Einstein Rockefeller CUNY Center for AIDS Research

ERC 爱因斯坦洛克菲勒纽约市立大学艾滋病研究中心

• 批准号: 10458265
• 负责人: Vilma Gabbay
• 金额: $ 4.16万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458265
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Anxiety; Area; Behavioral; Biological Markers; Brain; Caring; Clinical; Code; Cognition; Collaborations; Communities; Data; Databases; Depressive disorder; Diagnosis; Diagnostic; Enrollment; Epidemic; Epidemiology; Fostering; Funding; Future; Goals; Group Meetings; HIV; HIV therapy; Health; Health system; Immunologics; Immunology; Inflammation; Institutes; Institution; Interdisciplinary Study; Intervention; Investigation; Knowledge; Lead; Mental Depression; Mental Health; Mental disorders; Mission; National Institute of Drug Abuse; National Institute of Mental Health; Neurology; New York City; Outcome; Pain; Pathway interactions; Persons; Prevalence; Public Health; Research; Research Personnel; Research Project Grants; Resources; Risk; Substance Use Disorder; Technology; Translational Research; Universities; Work; addiction; antiretroviral therapy; base; burden of illness; cognitive neuroscience; cohort; comorbidity; depressive symptoms; experience; health disparity; implementation science; improved; interdisciplinary approach; interdisciplinary collaboration; member; multidisciplinary; neural circuit; neurochemistry; neuroimaging; neuroinflammation; neuropsychiatry; novel; pre-clinical; psychiatric comorbidity; recruit; substance use; transmission process; working group

PROJECT SUMMARY ERC-CFAR: HIV AND MENTAL HEALTH SCIENTIFIC WORKING GROUP The newly formed HIV and Mental Health Scientific Working Group (SWG) aims to facilitate multi-disciplinary investigations in the field of HIV and mental health comorbidity, a major public health concern, contributing to increased HIV transmission, and an undeveloped area of research in our ERC-CFAR. While dramatic survival gains have been achieved for people with HIV (PWH) with the widespread use of potent antiretroviral therapy (ART), high comorbidity with mental health conditions such as depression has posed a major barrier to achieving the 90-90-90 goal and “bending the curve.” National data estimate that comorbid mental health conditions impact the majority of PWH, leading to increased HIV transmission risk, reduced retention in care, and poorer HIV outcomes. Alarmingly, by 2030, the top two leading causes of disease burden globally are projected to be HIV and depressive disorders. Despite these data, there has been sparse research into the mechanisms underlying this comorbidity. This SWG addresses this major gap in HIV research with the overall mission of seeding and catalyzing research that impacts mental health in PWH to reduce HIV transmission and acquisition, and to improve retention in care and overall outcomes. Toward this goal, this SWG brings together with community members >30 non-HIV and HIV researchers with diverse expertise in immunology, neuroimaging, neurology, cognitive neuroscience, epidemiology, health disparities, and addiction, recruited from multiple New York City academic institutions. Specific Aims: 1) To bring together outstanding HIV and non-HIV investigators from multidisciplinary research areas and multiple NYC Institutions to foster collaborations in the field of mental health in PWH, focusing on psychiatric neuroimaging, neuroinflammation, and implementation science. 2) To generate new interdisciplinary collaborations among established investigators (EI) and Early Stage Investigators (ESI) who work on HIV research but have not previously collaborated, as well as with investigators who are new to HIV research. 3) To identify and seek funding for research projects developed through collaborations and ideas formed in the SWG to increase our understanding of the underlying mechanisms contributing to the high burden of mental health conditions among PWH, including depression, anxiety, cognition, and pain. Comorbid mental health conditions in PWH are a major public health concern and an obstacle to stopping the HIV epidemic partly due to increased transmission risk and decreased retention in care. To date, this topic has attracted limited research. This SWG aims to fill this research gap and facilitate research into the mechanisms underlying this comorbidity and how best to treat it. Such research is essential for ending the HIV epidemic.

项目概要 ERC-CFAR：艾滋病毒和心理健康科学工作组 新成立的艾滋病毒和心理健康科学工作组（SWG）旨在促进多学科研究 艾滋病毒和心理健康合并症领域的调查是一个主要的公共卫生问题，有助于 HIV 传播增加，以及我们的 ERC-CFAR 中尚未开发的研究领域。虽然戏剧性地生存下来 随着有效抗逆转录病毒疗法的广泛使用，艾滋病毒感染者 (PWH) 已取得了进展 （ART），与抑郁症等精神健康状况的高合并症已成为实现目标的主要障碍 90-90-90 的目标和“弯曲曲线”。国家数据估计共病心理健康状况的影响 大多数感染者，导致艾滋病毒传播风险增加、护理保留时间减少以及艾滋病毒感染状况较差 结果。令人震惊的是，到 2030 年，全球疾病负担的两大主要原因预计将是艾滋病毒 和抑郁症。尽管有这些数据，但对其背后机制的研究却很少 这种合并症。该 SWG 旨在解决艾滋病毒研究中的这一重大差距，其总体使命是播种和 促进影响艾滋病毒感染者心理健康的研究，以减少艾滋病毒传播和获得，并 提高护理保留率和整体结果。为了实现这一目标，该 SWG 与社区齐聚一堂 成员 > 30 名非 HIV 和 HIV 研究人员，在免疫学、神经影像学、神经病学、 认知神经科学、流行病学、健康差异和成瘾，从纽约多个城市招募 学术机构。具体目标： 1) 汇集来自世界各地的杰出艾滋病毒和非艾滋病毒研究人员 多学科研究领域和多个纽约机构促进心理健康领域的合作 在 PWH 领域，专注于精神神经影像学、神经炎症和实施科学。 2）生成 成熟研究者 (EI) 和早期研究者 (ESI) 之间新的跨学科合作 从事艾滋病毒研究但以前没有合作过的人，以及刚接触艾滋病毒的研究人员 艾滋病毒研究。 3) 为通过合作和想法开发的研究项目确定并寻求资金 在 SWG 中成立，以加深我们对导致高负担的根本机制的理解 感染者心理健康状况的调查，包括抑郁、焦虑、认知和疼痛。精神共病 艾滋病毒感染者的健康状况是一个主要的公共卫生问题，也是部分阻止艾滋病毒流行的障碍 由于传播风险增加和护理保留时间减少。迄今为止，该主题吸引的关注度有限 研究。该 SWG 旨在填补这一研究空白并促进对其背后机制的研究 合并症以及如何最好地治疗它。此类研究对于结束艾滋病毒流行至关重要。