ERC Einstein Rockefeller CUNY Center for AIDS Research

项目总结 ERC-CFAR：艾滋病毒和心理健康科学工作组 新成立的艾滋病毒和精神健康科学工作组(SWG)旨在促进多学科 在艾滋病毒和精神健康共病领域的调查，这是一个主要的公共卫生问题，有助于 艾滋病毒传播的增加，以及我们的ERC-CFAR中一个未开发的研究领域。虽然戏剧性的生存 随着有效的抗逆转录病毒疗法的广泛使用，艾滋病毒携带者(PWH)的治疗取得了进展 (ART)，高共病与抑郁症等精神健康状况构成了实现 90-90-90的目标和“弯曲曲线”。国家数据估计，共病的心理健康状况会影响 威斯康星医院的大多数人，导致艾滋病毒传播风险增加，护理保留率降低，艾滋病毒病情恶化 结果。令人担忧的是，到2030年，全球疾病负担的两大主要原因预计将是艾滋病毒 和抑郁障碍。尽管有这些数据，但对其背后的机制的研究一直很少 这种共病。这个SWG解决了艾滋病毒研究中的这一主要差距，总体使命是种子和 促进影响威尔斯亲王医院精神健康的研究，以减少艾滋病毒的传播和感染，并 改善护理中的保留率和总体结果。为了这个目标，这个SWG将社区聚集在一起 成员&>30名非艾滋病毒和艾滋病毒研究人员，他们在免疫学、神经成像、神经学、 从纽约多个城市招募的认知神经科学、流行病学、健康差异和成瘾 学术机构。具体目标：1)将优秀的艾滋病毒和非艾滋病毒调查人员从 多学科研究领域和纽约多个机构，促进精神健康领域的合作 在PWH，专注于精神神经成像、神经炎症和实施科学。2)生成 现有调查人员(EI)和早期调查人员(ESI)之间新的跨学科合作 他们从事艾滋病毒研究，但以前没有合作过，以及与新手调查人员合作 艾滋病毒研究。3)确定并为通过合作和想法开发的研究项目寻求资金 在SWG中成立，以增加我们对造成高负担的潜在机制的了解 威尔斯亲王的心理健康状况，包括抑郁、焦虑、认知和疼痛。共病精神病 威尔斯亲王医院的健康状况是一个主要的公共卫生问题，也是阻止艾滋病毒流行的部分障碍 由于传播风险增加和护理保留率降低。到目前为止，这个话题只吸引了有限的 研究。SWG旨在填补这一研究空白，并促进对其背后机制的研究 合并症以及如何最好地治疗。这样的研究对于结束艾滋病毒流行至关重要。

PROJECT SUMMARY ERC-CFAR: HIV AND MENTAL HEALTH SCIENTIFIC WORKING GROUP The newly formed HIV and Mental Health Scientific Working Group (SWG) aims to facilitate multi-disciplinary investigations in the field of HIV and mental health comorbidity, a major public health concern, contributing to increased HIV transmission, and an undeveloped area of research in our ERC-CFAR. While dramatic survival gains have been achieved for people with HIV (PWH) with the widespread use of potent antiretroviral therapy (ART), high comorbidity with mental health conditions such as depression has posed a major barrier to achieving the 90-90-90 goal and “bending the curve.” National data estimate that comorbid mental health conditions impact the majority of PWH, leading to increased HIV transmission risk, reduced retention in care, and poorer HIV outcomes. Alarmingly, by 2030, the top two leading causes of disease burden globally are projected to be HIV and depressive disorders. Despite these data, there has been sparse research into the mechanisms underlying this comorbidity. This SWG addresses this major gap in HIV research with the overall mission of seeding and catalyzing research that impacts mental health in PWH to reduce HIV transmission and acquisition, and to improve retention in care and overall outcomes. Toward this goal, this SWG brings together with community members >30 non-HIV and HIV researchers with diverse expertise in immunology, neuroimaging, neurology, cognitive neuroscience, epidemiology, health disparities, and addiction, recruited from multiple New York City academic institutions. Specific Aims: 1) To bring together outstanding HIV and non-HIV investigators from multidisciplinary research areas and multiple NYC Institutions to foster collaborations in the field of mental health in PWH, focusing on psychiatric neuroimaging, neuroinflammation, and implementation science. 2) To generate new interdisciplinary collaborations among established investigators (EI) and Early Stage Investigators (ESI) who work on HIV research but have not previously collaborated, as well as with investigators who are new to HIV research. 3) To identify and seek funding for research projects developed through collaborations and ideas formed in the SWG to increase our understanding of the underlying mechanisms contributing to the high burden of mental health conditions among PWH, including depression, anxiety, cognition, and pain. Comorbid mental health conditions in PWH are a major public health concern and an obstacle to stopping the HIV epidemic partly due to increased transmission risk and decreased retention in care. To date, this topic has attracted limited research. This SWG aims to fill this research gap and facilitate research into the mechanisms underlying this comorbidity and how best to treat it. Such research is essential for ending the HIV epidemic.