ERC Einstein Rockefeller CUNY Center for AIDS Research

ERC 爱因斯坦洛克菲勒纽约市立大学艾滋病研究中心

• 批准号: 10605281
• 负责人: Vilma Gabbay
• 金额: $ 5.05万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605281
• 关键词: Acquired Immunodeficiency Syndrome; Address; Anxiety; Area; Behavioral; Biological Markers; Brain; Caring; Clinical; Code; Cognition; Collaborations; Communities; Data; Databases; Depressive disorder; Diagnosis; Diagnostic; Enrollment; Epidemic; Epidemiology; Fostering; Funding; Future; Goals; Group Meetings; HIV; HIV/AIDS; Health; Health system; Immunology; Inflammation; Institution; Interdisciplinary Study; Intervention; Investigation; Knowledge; Mental Depression; Mental Health; Mental disorders; Mission; National Institute of Drug Abuse; National Institute of Mental Health; Neuroimmune; Neurology; New York City; Outcome; Pain; Pathway interactions; Persons; Prevalence; Public Health; Research; Research Personnel; Research Project Grants; Resources; Risk; Substance Use Disorder; Technology; Translational Research; Universities; Work; addiction; antiretroviral therapy; burden of illness; clinical translation; cognitive neuroscience; cohort; comorbidity; experience; health disparity; implementation science; improved; interdisciplinary approach; interdisciplinary collaboration; member; multidisciplinary; neural circuit; neurochemistry; neuroimaging; neuroinflammation; neuropsychiatry; novel; pre-clinical; psychiatric comorbidity; recruit; scientific organization; substance use; transmission process; working group

PROJECT SUMMARY ERC-CFAR: HIV AND MENTAL HEALTH SCIENTIFIC WORKING GROUP The newly formed HIV and Mental Health Scientific Working Group (SWG) aims to facilitate multi-disciplinary investigations in the field of HIV and mental health comorbidity, a major public health concern, contributing to increased HIV transmission, and an undeveloped area of research in our ERC-CFAR. While dramatic survival gains have been achieved for people with HIV (PWH) with the widespread use of potent antiretroviral therapy (ART), high comorbidity with mental health conditions such as depression has posed a major barrier to achieving the 90-90-90 goal and “bending the curve.” National data estimate that comorbid mental health conditions impact the majority of PWH, leading to increased HIV transmission risk, reduced retention in care, and poorer HIV outcomes. Alarmingly, by 2030, the top two leading causes of disease burden globally are projected to be HIV and depressive disorders. Despite these data, there has been sparse research into the mechanisms underlying this comorbidity. This SWG addresses this major gap in HIV research with the overall mission of seeding and catalyzing research that impacts mental health in PWH to reduce HIV transmission and acquisition, and to improve retention in care and overall outcomes. Toward this goal, this SWG brings together with community members >30 non-HIV and HIV researchers with diverse expertise in immunology, neuroimaging, neurology, cognitive neuroscience, epidemiology, health disparities, and addiction, recruited from multiple New York City academic institutions. Specific Aims: 1) To bring together outstanding HIV and non-HIV investigators from multidisciplinary research areas and multiple NYC Institutions to foster collaborations in the field of mental health in PWH, focusing on psychiatric neuroimaging, neuroinflammation, and implementation science. 2) To generate new interdisciplinary collaborations among established investigators (EI) and Early Stage Investigators (ESI) who work on HIV research but have not previously collaborated, as well as with investigators who are new to HIV research. 3) To identify and seek funding for research projects developed through collaborations and ideas formed in the SWG to increase our understanding of the underlying mechanisms contributing to the high burden of mental health conditions among PWH, including depression, anxiety, cognition, and pain. Comorbid mental health conditions in PWH are a major public health concern and an obstacle to stopping the HIV epidemic partly due to increased transmission risk and decreased retention in care. To date, this topic has attracted limited research. This SWG aims to fill this research gap and facilitate research into the mechanisms underlying this comorbidity and how best to treat it. Such research is essential for ending the HIV epidemic.

项目摘要 ERC-CFAR：艾滋病毒和心理健康科学工作组 新成立的艾滋病毒和心理健康科学工作组（SWG）旨在促进多学科 艾滋病毒和心理健康合并症领域的调查，这是一个主要的公共卫生问题，有助于 在我们的ERC-CFAR中增加了HIV传播和未开发的研究领域。而戏剧性的生存 通过使用潜在抗逆转录病毒疗法的宽度，艾滋病毒（PWH）的人已获得收益 （艺术），在精神健康状况（例如抑郁症）方面的合并症很高，已经实现了实现的主要障碍 90-90-90的进球和“弯曲曲线”。国家数据估计合并症心理健康状况会影响 大多数PWH，导致HIV传播风险增加，护理中的保留率降低，HIV较差 结果。令人震惊的是，到2030年，全球疾病燃烧的前两个主要原因预计为艾滋病毒 和抑郁症。尽管有这些数据，但对基本机制的研究很少 这种合并症。这种SWG解决了艾滋病毒研究的这一主要差距，并具有播种和 催化影响PWH心理健康以减少艾滋病毒传播和获取的研究，并 改善护理和整体成果的保留率。为了实现这一目标，这种SWG与社区融为一体 成员> 30名非HIV和HIV研究人员具有免疫学，神经影像学，神经病学专业知识， 认知神经科学，流行病学，健康差异和成瘾，从多个纽约市招募 学术机构。具体目的：1）从 多学科研究领域和多个纽约市机构，以促进心理健康领域的合作 在PWH中，专注于精神病神经影像学，神经炎症和实施科学。 2）生成 既定研究者（EI）和早期研究人员（ESI）之间的新跨学科合作 谁从事艾滋病毒研究但以前从未合作，以及与新手的调查人员合作 艾滋病毒研究。 3）确定并寻求通过协作和想法开发的研究项目的资金 在SWG中形成，以增加我们对导致高负担的基本机制的理解 PWH中的心理健康状况，包括抑郁，焦虑，认知和疼痛。合并的精神状况 PWH的健康状况是一个主要的公共卫生问题，也是阻止HIV流行的障碍 由于传输风险增加和护理保留率下降。迄今为止，这个话题吸引了有限 研究。该SWG旨在填补这一研究差距，并促进对此基础机制的研究 合并症以及如何最好地对待它。这种研究对于结束HIV流行至关重要。