ERC Einstein Rockefeller CUNY Center for AIDS Research

ERC 爱因斯坦洛克菲勒纽约市立大学艾滋病研究中心

• 批准号: 10605281
• 负责人: Vilma Gabbay
• 金额: $ 5.05万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605281
• 关键词: Acquired Immunodeficiency Syndrome; Address; Anxiety; Area; Behavioral; Biological Markers; Brain; Caring; Clinical; Code; Cognition; Collaborations; Communities; Data; Databases; Depressive disorder; Diagnosis; Diagnostic; Enrollment; Epidemic; Epidemiology; Fostering; Funding; Future; Goals; Group Meetings; HIV; HIV/AIDS; Health; Health system; Immunology; Inflammation; Institution; Interdisciplinary Study; Intervention; Investigation; Knowledge; Mental Depression; Mental Health; Mental disorders; Mission; National Institute of Drug Abuse; National Institute of Mental Health; Neuroimmune; Neurology; New York City; Outcome; Pain; Pathway interactions; Persons; Prevalence; Public Health; Research; Research Personnel; Research Project Grants; Resources; Risk; Substance Use Disorder; Technology; Translational Research; Universities; Work; addiction; antiretroviral therapy; burden of illness; clinical translation; cognitive neuroscience; cohort; comorbidity; experience; health disparity; implementation science; improved; interdisciplinary approach; interdisciplinary collaboration; member; multidisciplinary; neural circuit; neurochemistry; neuroimaging; neuroinflammation; neuropsychiatry; novel; pre-clinical; psychiatric comorbidity; recruit; scientific organization; substance use; transmission process; working group

PROJECT SUMMARY ERC-CFAR: HIV AND MENTAL HEALTH SCIENTIFIC WORKING GROUP The newly formed HIV and Mental Health Scientific Working Group (SWG) aims to facilitate multi-disciplinary investigations in the field of HIV and mental health comorbidity, a major public health concern, contributing to increased HIV transmission, and an undeveloped area of research in our ERC-CFAR. While dramatic survival gains have been achieved for people with HIV (PWH) with the widespread use of potent antiretroviral therapy (ART), high comorbidity with mental health conditions such as depression has posed a major barrier to achieving the 90-90-90 goal and “bending the curve.” National data estimate that comorbid mental health conditions impact the majority of PWH, leading to increased HIV transmission risk, reduced retention in care, and poorer HIV outcomes. Alarmingly, by 2030, the top two leading causes of disease burden globally are projected to be HIV and depressive disorders. Despite these data, there has been sparse research into the mechanisms underlying this comorbidity. This SWG addresses this major gap in HIV research with the overall mission of seeding and catalyzing research that impacts mental health in PWH to reduce HIV transmission and acquisition, and to improve retention in care and overall outcomes. Toward this goal, this SWG brings together with community members >30 non-HIV and HIV researchers with diverse expertise in immunology, neuroimaging, neurology, cognitive neuroscience, epidemiology, health disparities, and addiction, recruited from multiple New York City academic institutions. Specific Aims: 1) To bring together outstanding HIV and non-HIV investigators from multidisciplinary research areas and multiple NYC Institutions to foster collaborations in the field of mental health in PWH, focusing on psychiatric neuroimaging, neuroinflammation, and implementation science. 2) To generate new interdisciplinary collaborations among established investigators (EI) and Early Stage Investigators (ESI) who work on HIV research but have not previously collaborated, as well as with investigators who are new to HIV research. 3) To identify and seek funding for research projects developed through collaborations and ideas formed in the SWG to increase our understanding of the underlying mechanisms contributing to the high burden of mental health conditions among PWH, including depression, anxiety, cognition, and pain. Comorbid mental health conditions in PWH are a major public health concern and an obstacle to stopping the HIV epidemic partly due to increased transmission risk and decreased retention in care. To date, this topic has attracted limited research. This SWG aims to fill this research gap and facilitate research into the mechanisms underlying this comorbidity and how best to treat it. Such research is essential for ending the HIV epidemic.

项目摘要 ERC-CFAR：艾滋病毒和心理健康科学工作组 新成立的爱滋病病毒及精神健康科学工作小组（SWG），旨在促进多学科 艾滋病毒和精神卫生并发症领域的调查，这是一个主要的公共卫生问题，有助于 艾滋病毒传播的增加，以及我们的ERC-CFAR研究的一个未开发领域。虽然戏剧性的生存 随着强效抗逆转录病毒疗法的广泛使用，艾滋病毒感染者（PWH）的治疗已经取得了进展 (ART)与抑郁症等心理健康状况的高共病率构成了实现目标的主要障碍， 90-90-90的目标和“弯曲曲线”。国家数据估计，共病心理健康状况影响 大部分的威尔斯亲王医院，导致艾滋病毒传播的风险增加，减少继续护理， 结果。令人担忧的是，到2030年，预计全球疾病负担的两大主要原因将是艾滋病毒 和抑郁症。尽管有这些数据，但对潜在机制的研究很少 这个科摩罗。本工作组通过播种和传播的总体使命， 促进影响威尔斯亲王医院精神健康的研究，以减少艾滋病毒的传播和感染， 改善护理保留率和总体结果。为了实现这一目标，这个SWG汇集了社区 成员>30名非艾滋病毒和艾滋病毒研究人员，在免疫学，神经影像学，神经病学， 认知神经科学、流行病学、健康差异和成瘾，从多个纽约市招募 学术机构具体目标：1）汇集来自世界各地的杰出艾滋病毒和非艾滋病毒调查人员， 多学科研究领域和多个纽约市机构，以促进心理健康领域的合作 在PWH，专注于精神病学神经影像学，神经炎症和实施科学。2)完成网站 现有研究者（EI）和早期研究者（ESI）之间新的跨学科合作 从事艾滋病毒研究但以前没有合作过的研究人员，以及新的研究人员， 艾滋病毒研究。3)为通过合作和想法开发的研究项目确定并寻求资金 在SWG中形成，以增加我们对导致高负担的潜在机制的理解 威尔斯亲王医院的精神健康状况，包括抑郁、焦虑、认知和疼痛。精神共病 威尔斯亲王医院的健康状况是一个主要的公共卫生问题，也是部分阻止艾滋病毒流行的障碍。 由于传播风险增加和护理保留减少。到目前为止，这个话题已经吸引了有限的 research.本工作组旨在填补这一研究空白，并促进对这一机制的研究。 这些研究对于结束艾滋病的流行至关重要。