Clinical Laboratory & Biomarker Core
Clinical Laboratory & Biomarker Core
批准号:
10458362
负责人:
Craig Walter Hendrix
金额:
$56.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
未结题
起止时间:
2012-05-02 至 2027-04-30
关键词:
AIDS preventionAcquired Immunodeficiency SyndromeAreaAwarenessBiologicalBiological AssayBiological MarkersBiological Specimen BanksBiological TestingCatalogingClinicClinicalClinical DataClinical ResearchCollaborationsConsultConsultationsDataData AnalysesDevelopmentEducational process of instructingEquipment and supply inventoriesFacultyFreezingGoalsGuidelinesHIVHIV InfectionsImmunologyInstitutionInternationalInternetInvestigationKnowledgeLaboratoriesMaintenanceMeasuresMentorsMethodsNatural HistoryOutcome StudyPathogenesisPerformancePharmacologyPractice ManagementPreventionPublicationsQuality ControlReadinessResearchResearch PersonnelResourcesSamplingScienceScientistService provisionServicesSpecimenStudentsTestingTissue BanksTrainingbasebiobankdata integritydata managementdesignimprovedinnovationmetabolomicsnext generationprogramsquality assurancerepositorysearchable databaseservice providersvirologyworking group
中文摘要
JHUCFAR实验室核心的总体目标是为JHU HIV研究人员,特别是那些
新的艾滋病毒,具有:a)世界一流的实验室专业知识,以协助临床研究的最佳设计
如果专门的实验室检测对于测量研究结果至关重要,B)获得
适当的、经验证的和(如适用)经认证的实验室测定,c)生物标志物标本
生物标本的储存、编目和测试库,包括进入
与这些标本相关的临床数据,以及d)培训以满足研究者的需求
从了解如何与实验室研究人员合作,
临床研究中的检测,判断检测质量和准备使用的检测的实际性能,
自己的实验室。该核心将建立机制,加强艾滋病毒预防研究,
治疗和发病机制进行了新的和建立的研究人员在JHU通过
提高对机构内广泛实验室资源的认识和利用,
在需要的时候建立与约翰霍普金斯以外的联系。为此,核心将直接提供
专家咨询和分析服务集中在4个主要科学领域-病毒学,免疫学,
药理学和代谢组学-以及提供对数据和生物标本的访问
知识库来推进科学。除了这些实验室,核心将建立最好的数据,
管理实践-从诊所到实验室到数据分析-并促进连接和
与JHU和全国其他CFAR内更广泛的核心实验室合作。
英文摘要
The overall goals of the JHUCFAR Laboratory core are to provide JHU HIV researchers, especially those
new to HIV, with: a) world‐class laboratory expertise to assist in the optimal design of clinical studies
where specialized laboratory assays are essential to measuring study outcomes, b) access to
appropriate, validated and, where applicable, certified laboratory assays, c) biomarker specimen
repository for the storage, cataloguing and testing of biological specimens, including access to the
clinical data associated with those specimens, and d) training to match the needs of investigators
ranging from understanding how to collaborate with laboratory investigators, incorporate laboratory
tests in a clinical study, judge assay quality and readiness for use to actual performance of the assays in
one’s own laboratory. The Core will establish mechanisms to enhance research in HIV prevention,
treatment, and pathogenesis carried out by both new and established investigators at JHU through
improved awareness of and access to the extensive laboratory resources within the institution and by
establishing connections outside Johns Hopkins when needed. To this end, the Core will directly provide
expert consultation and assay service focused in 4 major scientific areas—virology, immunology,
pharmacology, and metabolomics—as well as providing access to both data and biological specimen
repositories to advance science. Beyond these laboratories, the Core will establish best data
management practices – from clinic to lab to data analysis – and facilitate connections and
collaborations with a far broader array of core laboratories within JHU and in other CFARs nationally.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Phosphorylation of Drugs in Colonic Tissue
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批准号:10653625
-
项目类别:
-
资助金额:$72.56万
-
财政年份:2022
-
负责人:Craig Walter Hendrix
-
依托单位:
Population Pharmacokinetic Modeling and Clinical Trial Simulation to optimize HIV Prevention in Pregnancy and Postpartum
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批准号:10316144
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项目类别:
-
资助金额:$23.53万
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财政年份:2021
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负责人:Craig Walter Hendrix
-
依托单位:
Development of Rectal Enema As Microbicide (DREAM)
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批准号:9088326
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项目类别:
-
资助金额:$461.2万
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财政年份:2014
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负责人:Craig Walter Hendrix
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依托单位:
Exploratory Pharmcokinetics of UC781 & Tenofovir Vaginal Microbicide Gel V Film
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批准号:8660270
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项目类别:
-
资助金额:$37.48万
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财政年份:2014
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负责人:Craig Walter Hendrix
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依托单位:
Clinical optimization of a tenofovir enema and adherence tracking
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批准号:8768695
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项目类别:
-
资助金额:$102.52万
-
财政年份:2014
-
负责人:Craig Walter Hendrix
-
依托单位:
Exploratory Pharmcokinetics of UC781 & Tenofovir Vaginal Microbicide Gel V Film
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批准号:8471644
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项目类别:
-
资助金额:$33.54万
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财政年份:2013
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负责人:Craig Walter Hendrix
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依托单位:
The effect of Depo-Provera on HIV susceptibility, immune activation, and PrEP PK
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批准号:8588047
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项目类别:
-
资助金额:$41.31万
-
财政年份:2013
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负责人:Craig Walter Hendrix
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依托单位:
Pre-Phase I Evaluations
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批准号:8404840
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项目类别:
-
资助金额:$57.56万
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财政年份:2012
-
负责人:Craig Walter Hendrix
-
依托单位:
Clinical Laboratory & Biomarker Core
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批准号:10612986
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项目类别:
-
资助金额:$48.76万
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财政年份:2012
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负责人:Craig Walter Hendrix
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依托单位:
Laboratory and Biomarkers Core
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批准号:10153642
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项目类别:
-
资助金额:$37.41万
-
财政年份:2012
-
负责人:Craig Walter Hendrix
-
依托单位:
Exploratory Pharmcokinetics of UC781 & Tenofovir Vaginal Microbicide Gel V Film
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批准号:7898237
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项目类别:
-
资助金额:$33.54万
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财政年份:2010
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负责人:Craig Walter Hendrix
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依托单位:
Phase I rectally-formulated rectal microbicide
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批准号:7979337
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项目类别:
-
资助金额:$58.28万
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财政年份:2009
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负责人:Craig Walter Hendrix
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依托单位:
METHADONE QD WITH FOSAMPRENAVIR
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批准号:7604740
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项目类别:
-
资助金额:$16.0万
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财政年份:2006
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负责人:Craig Walter Hendrix
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依托单位:
A POTENTIAL RECTAL MICROBICIDE VEHICLE AND SEMEN SURROGATE
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批准号:7604565
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项目类别:
-
资助金额:$3.53万
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财政年份:2006
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负责人:Craig Walter Hendrix
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依托单位:
P5 - Effect of Rectal Preparatory Enemas on Microbicide Distribution, Tox
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批准号:7127917
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项目类别:
-
资助金额:$75.52万
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财政年份:2006
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负责人:Craig Walter Hendrix
-
依托单位:
INTERACTION BETWEEN AMD 11070 AND SUSTRATES OF CYP3A4 AND 2D6 ENZYMES
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批准号:7604678
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项目类别:
-
资助金额:$1.39万
-
财政年份:2006
-
负责人:Craig Walter Hendrix
-
依托单位:
METHADONE QD WITH FOSAMPRENAVIR
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批准号:7378989
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项目类别:
-
资助金额:$28.21万
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财政年份:2005
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负责人:Craig Walter Hendrix
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依托单位:
COLLECTION OF BIOLOGICAL SAMPLES FOR LAB ASSAY DEVELOPMENT
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批准号:7200734
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项目类别:
-
资助金额:$0.9万
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财政年份:2005
-
负责人:Craig Walter Hendrix
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依托单位:
SAMPLING FREQUENCY LIMITATIONS OF ANTIRETROVIRAL DRUGS
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批准号:7200738
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项目类别:
-
资助金额:$13.09万
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财政年份:2005
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负责人:Craig Walter Hendrix
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依托单位:
A POTENTIAL RECTAL MICROBICIDE VEHICLE AND SEMEN SURROGATE
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批准号:7200749
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项目类别:
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资助金额:$3.86万
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财政年份:2005
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负责人:Craig Walter Hendrix
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依托单位:
海外基金