A POTENTIAL RECTAL MICROBICIDE VEHICLE AND SEMEN SURROGATE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目将研究几个关键问题，以开发一种用于预防人类免疫缺陷病毒（HIV）通过直肠性交传播的杀微生物剂。 提出了三项研究。 第一项研究将检查应用于直肠的候选杀微生物剂载体的分布和清除率（Cl）。 第二个将检查应用于直肠的精液替代物的分布和清除。 第三项研究将评价杀微生物剂溶媒和精液替代品的分布和清除。在每项研究中，比较了几种不同的方式（磁共振成像[MRI]，单光子发射计算机断层扫描[SPECT]，计算机断层扫描[CT]和通过内窥镜直接采样），以确定最佳技术。 研究将在男性同性性行为（MSM）的健康志愿者中进行，这些男性既往有接受性直肠性交史，并报告使用肛门扩张器。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine several questions critical to the development of a microbicide agent to be used for the prevention of transmission of the Human Immunodeficiency Virus (HIV) via rectal intercourse. Three studies are proposed. The first will examine the distribution and clearance (Cl) of a candidate microbicide vehicle applied to the rectum. The second will examine the distribution and clearance of a semen surrogate applied to the rectum. The third study will evaluate the distribution and clearance of the microbicide vehicle and semen surrogate together. In each study, several different modalities are compared (magnetic resonance imaging [MRI], single photon emission computed tomography [SPECT], computed tomography [CT], and direct sampling via endoscopy), in order to determine the optimal technique. Studies will be carried out in healthy volunteer men who have sex with men (MSM) who have a previous history of receptive rectal intercourse and who report use of anal dilators.