Clinical Laboratory & Biomarker Core

临床实验室

• 批准号: 10612986
• 负责人: Craig Walter Hendrix
• 金额: $ 48.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-02 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612986
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Area; Awareness; Biological; Biological Assay; Biological Markers; Biological Specimen Banks; Biological Testing; Cataloging; Certification; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Consult; Consultations; Data; Data Analyses; Development; Educational process of instructing; Equipment and supply inventories; Faculty; Goals; Guidelines; HIV; HIV Infections; Immunology; Institution; International; Internet; Investigation; Knowledge; Laboratories; Maintenance; Measures; Mentors; Methods; Natural History; Outcome Study; Pathogenesis; Performance; Pharmacology; Practice Management; Prevention; Publications; Quality Control; Readiness; Research; Research Personnel; Resources; Sampling; Science; Scientist; Service provision; Services; Specimen; Students; Testing; Tissue Banks; Training; biobank; data integrity; data management; design; improved; innovation; metabolomics; next generation; programs; quality assurance; repository; searchable database; service providers; virology; working group

The overall goals of the JHUCFAR Laboratory core are to provide JHU HIV researchers, especially those new to HIV, with: a) world‐class laboratory expertise to assist in the optimal design of clinical studies where specialized laboratory assays are essential to measuring study outcomes, b) access to appropriate, validated and, where applicable, certified laboratory assays, c) biomarker specimen repository for the storage, cataloguing and testing of biological specimens, including access to the clinical data associated with those specimens, and d) training to match the needs of investigators ranging from understanding how to collaborate with laboratory investigators, incorporate laboratory tests in a clinical study, judge assay quality and readiness for use to actual performance of the assays in one’s own laboratory. The Core will establish mechanisms to enhance research in HIV prevention, treatment, and pathogenesis carried out by both new and established investigators at JHU through improved awareness of and access to the extensive laboratory resources within the institution and by establishing connections outside Johns Hopkins when needed. To this end, the Core will directly provide expert consultation and assay service focused in 4 major scientific areas—virology, immunology, pharmacology, and metabolomics—as well as providing access to both data and biological specimen repositories to advance science. Beyond these laboratories, the Core will establish best data management practices – from clinic to lab to data analysis – and facilitate connections and collaborations with a far broader array of core laboratories within JHU and in other CFARs nationally.

JHUCFAR实验室核心的总体目标是为JHU HIV研究人员，特别是那些 新的艾滋病毒，具有：a）世界一流的实验室专业知识，以协助临床研究的最佳设计 如果专门的实验室检测对于测量研究结果至关重要，B）获得 适当的、经验证的和（如适用）经认证的实验室测定，c）生物标志物标本 生物标本的储存、编目和测试库，包括进入 与这些标本相关的临床数据，以及d）培训以满足研究者的需求 从了解如何与实验室研究人员合作， 临床研究中的检测，判断检测质量和准备使用的检测的实际性能， 自己的实验室。该核心将建立机制以加强艾滋病毒预防研究， 治疗和发病机制进行了新的和建立的研究人员在JHU通过 提高对机构内广泛实验室资源的认识和利用， 在需要的时候建立与约翰霍普金斯以外的联系。为此，核心将直接提供 专家咨询和分析服务集中在4个主要科学领域-病毒学，免疫学， 药理学和代谢组学-以及提供对数据和生物标本的访问 知识库来推进科学。除了这些实验室，核心将建立最好的数据， 管理实践-从诊所到实验室到数据分析-并促进连接和 与JHU和全国其他CFAR内更广泛的核心实验室合作。