权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Development and Pilot Testing of a Just in Time Mobile Smoking Cessation Intervention for Persons living with HIV

针对艾滋病毒感染者的及时移动戒烟干预措施的开发和试点测试

基本信息

批准号：
10459617
负责人：
Ming-Chun Huang
金额：
$ 22.39万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10459617
关键词：
Abstinence Address Adult Area Behavior assessment Caring Cigarette Clinic Clinical Trials Coffee Communities Complex Counseling Data Development Ensure Equilibrium Feedback Focus Groups Friends General Population Geography Gestures Global Positioning System HIV HIV Seropositivity Hand Health Health Technology Health behavior Health behavior change High Prevalence Home Incidence Intervention Knowledge Life Expectancy Lighting Link Methodology Morbidity - disease rate Motion Motivation National Cancer Institute Neurocognitive Neurocognitive Deficit New York City Outcome Participant Patients Persons Population Prevalence Principal Investigator Qualitative Methods Quality of life Randomized Randomized Controlled Trials Reach Effectiveness Adoption Implementation and Maintenance Relapse Research Risk Factors Sample Size Sampling Savings Self Efficacy Series Smoke Smoker Smoking Smoking Cessation Intervention Software Engineering Technology Testing Text Text Messaging Time Tobacco Tobacco Use Cessation Tobacco use Tobacco-Related Carcinoma United States Viral Load result artificial intelligence algorithm base cigarette smoke cigarette smoking computer human interaction cost craving design disorder later incidence prevention evidence base experience former smoker health disparity improved improved outcome innovation mHealth mortality multi-component intervention nicotine replacement pilot test pilot trial prevent programs recruit reduce tobacco use response scale up sensor smart watch smartphone Application smoking cessation smoking prevalence smoking relapse smoking-related disease success tobacco cessation intervention tool usability wearable sensor technology

项目摘要

PROJECT SUMMARY This application, in direct response to PAR-19-309, will systematically develop and pilot test the Sense2Quit App to improve tobacco cessation in persons living with HIV (PLWH). The prevalence of cigarette smoking among PLWH is more than three times that of the general adult United States (U.S.) population. The high prevalence of cigarette smoking and the high incidence of tobacco-related cancer and other smoking-related diseases among PLWH calls for swift action to intervene to reduce tobacco use rates. However, evidence to guide tobacco cessation in PLWH is inadequate. To address this need, our team proposes to develop, and pilot test the Sense2Quit App, a multi-component smartphone app which provides just-in-time feedback; specifically addresses challenges to tobacco cessation for PLWH: slips, relapses, and difficulties associated with neurocognitive deficits; supports both self-efficacy and decisional balance; and provides quit plan reminders. The artificial intelligence algorithm (validated by our study team) interprets data from a smartwatch to detect smoking hand motions – a technology with more than 98% accuracy in differentiating “lighting up” from other similar motions. The Sense2Quit App leverages smartwatch data and detects when and where smoking activity occurs so that a message can be sent in real time to the participant to help them manage the slip (a puff or two) from becoming a relapse. This just-in-time feedback is critical especially in the first few weeks of a quit attempt. Additionally, Global Positioning System data can help participants avoid triggers (coffee shops, smoking relatives, or friends' homes, etc.). Finally, the Sense2Quit App provides information on how well smokers are progressing through their quit plan, support tips, and motivational tools (i.e., badges related to saving money from not purchasing cigarettes). The specific aims of the proposed study are to: 1) Explore and identify, using qualitative methods, acceptable and appropriate app content and features of the Sense2Quit App to support smoking cessation and relapse prevention in PLWH who smoke; 2) Conduct a pilot randomized controlled trial to examine the feasibility, acceptability, and preliminary efficacy of the Sense2Quit App in a sample of 60 PLWH who smoke; and 3) Employ the RE-AIM framework to assess the potential scale-up of the Sense2Quit App. As part of the pilot trial, we will randomize 60 HIV-positive smokers to the Sense2Quit App, standard smoking cessation counseling, and nicotine replacement therapy (active condition) versus standard smoking cessation counseling plus nicotine replacement therapy (control) and examine group differences in rate of quit attempts, 7-day point prevalence abstinence, and sustained abstinence. We will calculate an effect size estimate of the Sense2Quit App to guide, in part, the sample size needed for a larger scale clinical trial. The knowledge gained from the proposed research will enable the scientific community and patients to improve tobacco cessation in those persons who are in most need in the U.S. Given our team's unique and complementary expertise in each of the areas necessary to develop an innovative smoking cessation intervention to improve outcomes among PLWH, we are confident that the findings from this study will be easily scaled-up for further testing to ensure improvement in health outcomes for PLWH.

项目概要该应用程序直接响应 PAR-19-309，将系统地开发和试点测试 Sense2Quit 应用程序，以改善艾滋病毒感染者（PLWH）的戒烟。艾滋病病毒感染者（PLWH）中吸烟的流行率为是美国普通成年人口的三倍多。吸烟率高艾滋病病毒感染者中与烟草相关的癌症和其他吸烟相关疾病的高发病率呼吁迅速采取行动进行干预以降低烟草使用率。然而，指导艾滋病病毒感染者戒烟的证据并不充分。到为了满足这一需求，我们的团队建议开发并试点测试 Sense2Quit 应用程序，这是一款多组件智能手机应用程序提供及时的反馈；专门解决 PLWH 戒烟面临的挑战：失误、复吸、以及与神经认知缺陷相关的困难；支持自我效能和决策平衡；并提供退出计划提醒。人工智能算法（由我们的研究团队验证）解释来自智能手表的数据检测吸烟的手部动作——这项技术能够区分“点燃”和其他动作，准确率超过 98% 类似的动议。 Sense2Quit 应用程序利用智能手表数据并检测吸烟活动发生的时间和地点，以便可以实时向参与者发送一条消息，以帮助他们控制滑倒（一两口），以免成为复发。这种及时的反馈至关重要，尤其是在尝试戒烟的最初几周。此外，全球定位系统数据可以帮助参与者避免触发因素（咖啡店、吸烟的亲戚或朋友家等）。最后，Sense2Quit 应用程序提供有关吸烟者戒烟计划进展情况的信息、支持提示和激励工具（即与不购买香烟省钱相关的徽章）。该计划的具体目标拟议的研究旨在： 1) 使用定性方法探索和识别可接受且适当的应用程序内容，以及 Sense2Quit 应用程序支持吸烟的感染者戒烟和预防复吸的功能； 2) 进行试点随机对照试验，以检验 Sense2Quit 应用程序的可行性、可接受性和初步功效在 60 名吸烟的感染者的样本中； 3) 采用 RE-AIM 框架来评估扩大规模的潜力 Sense2Quit 应用程序。作为试点试验的一部分，我们将随机将 60 名 HIV 阳性吸烟者随机分配到 Sense2Quit 应用程序（标准）戒烟咨询和尼古丁替代疗法（主动状态）与标准戒烟对比咨询加尼古丁替代疗法（对照）并检查戒烟尝试率的组间差异，7 天点普遍戒断和持续戒断。我们将计算 Sense2Quit 应用程序的效应大小估计值来指导，在某种程度上，更大规模的临床试验所需的样本量。从拟议的研究中获得的知识将使科学界和患者能够改善最需要帮助的人的戒烟情况鉴于我们的团队在开发创新所需的每个领域都拥有独特且互补的专业知识戒烟干预以改善 PLWH 的结果，我们相信这项研究的结果将很容易扩大规模以进行进一步测试，以确保改善感染者的健康结果。