SPECT Imaging of Peripheral Vascular Disease

在这个项目中，我们将开发一个所谓的动态SPECT（DE-SPECT）系统， 利用三维HEXIETC CZT探测器技术和合成复眼相机设计， 下肢PVD的多示踪剂SPECT成像。 周围血管疾病（PVD）影响大约800万美国人，估计10%的美国人患有这种疾病。 在世界范围内，老年人的患病率越来越高。PVD具有显著的健康影响， 导致进行性肢体缺血，这可导致改变生命的跛行、不愈合的溃疡、肢体缺血、 截肢，严重者甚至死亡。尽管这些数字和冠状动脉的密切联系， 虽然PVD是一种疾病，但它仍然是一种相对诊断不足的疾病。糖尿病患者经常需要血运重建 沿着医疗和生活方式干预，以实现症状缓解、伤口愈合和保肢， 与非血管化患者相比， DM患者。尽管治疗大血管疾病和恢复骨骼肌灌注对于 严重的肢体缺血和间歇性跛行的关键贡献者，还有其他重要的代谢 和分子异常，需要结合肌肉灌注的变化进行评估 以优化治疗。阻塞血管的血运重建通常导致不完全或 血流恢复不均匀，不能完全恢复PAD患者的功能限制， 间歇性跛行 所提出的DE-SPECT系统可以提供一种独特的非侵入性方法， 外周血管病患者下肢分子和生理变化的评估 疾病（PVD）对治疗干预的反应，并评估这些变化将是至关重要的优化 PVD治疗后。

In this proposed project, we will develop a so-called Dynamic Extremity SPECT (DE-SPECT) system that utilizes the 3-D HEXIETC CZT detector technology and a synthetic compound-eye camera design for dynamic and multi-tracer SPECT imaging of PVD in lower extremities. Peripheral Vascular Disease (PVD) affects approximately 8 million Americans and an estimated 10% of the worldwide population, with increasing prevalence in older individuals. PVD has significant health implications, resulting in progressive limb ischemia that can lead to life-altering claudication, non-healing ulcers, limb amputation, and, in severe cases, death. Despite these numbers and a close association with coronary artery disease, PVD remains a relatively under-diagnosed disease. Diabetic patients often require revascularization along with medical and life style interventions to achieve symptom relief, wound healing and limb salvage and have higher rates of restenosis, and higher mortality rates following revascularization when compared to non- DM patients. Although treating large vessel disease and restoration of skeletal muscle perfusion is important for critical limb ischemia and a critical contributor to intermittent claudication, there are other important metabolic and molecular abnormalities involved that need to be evaluated in conjunction with changes in muscle perfusion in order to optimize therapy. Revascularization of obstructed vessels often results in an incomplete or heterogeneous restoration of flow and does not fully restore the functional limitations in PAD patients with intermittent claudication. The proposed DE-SPECT system could provide a unique non-invasive approach for the comprehensive assessment of molecular and physiological changes of the lower extremities in patients with peripheral vascular disease (PVD) in response to therapeutic interventions and assessing these changes will be critical for optimizing and following PVD therapy.