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Imaging Core

成像核心

基本信息

批准号：
10460471
负责人：
GALATEIA J KAZAKIA
金额：
$ 11.2万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460471
关键词：
Adoption Animal Model Biochemical Biochemistry Biology Biomechanics Body Composition Cartilage Clinical Clinical Research Collaborations Communities Consultations Custom Data Development Disease Education Educational workshop Evaluation Goals Grant Histologic Histology Human Image Image Analysis Individual Investigation Knowledge Link Magnetic Resonance Imaging Mathematics Measures Medicine Methodology Methods Minor Mission Multimodal Imaging Muscle Musculoskeletal Musculoskeletal System Optical Tomography Physics Physiology Positron-Emission Tomography Procedures Relaxation Research Research Personnel Services Structure Students Suggestion Techniques Technology Texture Time Tissue Sample Tissues Training Visualization Visualization software Work X-Ray Computed Tomography base biological systems bone clinically relevant computerized data processing cortical bone design experience image processing imaging capabilities imaging informatics imaging software in vivo innovation interest magnetic resonance spectroscopic imaging morphometry novel novel imaging technology outreach pre-clinical quantitative imaging reconstruction serial imaging single photon emission computed tomography statistics substantia spongiosa tool web portal

项目摘要

The goal of the Imaging Core is to provide state-of-the-art, customized image acquisition, reconstruction, and quantitative analysis for pre-clinical (tissue samples and animal models) and in vivo human musculoskeletal research. These will include pre-clinical and clinical: 1) acquisition and reconstruction of MRI/MRSI, PET, SPECT, CT, and optical tomography data; 2) spatial registration of multi-modality images; 3) extraction of quantitative information concerning biologically relevant image parameters; and 4) evaluation of the relationships of these imaging-derived parameters to biochemistry, histology, biomechanics, and physiology of biological systems interacting with the musculoskeletal system. Many of these procedures are novel and require specialized knowledge of imaging physics and mathematics. Investigators linked to the Imaging Core have extensive experience in these imaging and quantitative analysis techniques and will work closely with CCMBM investigators to match and/or develop the best imaging and data processing methods to their specific research questions. Innovation and Service: Aim 1: To develop, maintain, and support state-of-the-art quantitative image acquisition and reconstruction methods for pre-clinical and human musculoskeletal tissues. Aim 2: To develop novel image grading and quantitative analysis and to provide templates, training, and implement robust measures for clinical grading of radiographs, CT and MR images, and software packages for post-processing, visualization, and quantitative analysis. Aim 3: To provide interpretation of imaging data from single and serial imaging examinations and assess links to biochemical, histological, and biomechanical measures that are extracted and the relevant clinical or experimental endpoints. Education and Dissemination: The overarching goal will be to promote development and adoption of state-of- the-art imaging methodology in musculoskeletal research. Aim 4: To provide web portal access to examples of previous studies that have used imaging endpoints and detailed descriptions of clinical and research imaging services, and to handle new service requests efficiently though the web portal. Aim 5: To perform proactive outreach to attract potential new users and participate in CCMBM seminar activities to provide imaging seminars, workshops, and facilities tours that will introduce new imaging and image processing capabilities to the CCMBM community, with particular focus on junior and early stage investigators.

成像核心的目标是提供最先进的，定制的图像采集，重建，