Imaging Core

成像核心的目标是提供最先进的、定制的图像采集、重建、 临床前(组织样本和动物模型)和活体人类的定量分析 肌肉骨骼研究。这些将包括临床前和临床：1)获取和重建 MRI/MRSI、PET、SPECT、CT和光学断层扫描数据；2)多模式图像的空间配准；3) 提取与生物相关的图像参数有关的定量信息；以及4)评估 这些成像衍生参数与生化、组织学、生物力学和 生物系统与肌肉骨骼系统相互作用的生理学。这些程序中有许多是 新颖，需要成像物理和数学方面的专业知识。与这起事件有关的调查人员 成像核心在这些成像和定量分析技术方面拥有丰富的经验，并将工作 与CCMBM调查人员密切合作，匹配和/或开发最佳的成像和数据处理方法 他们的具体研究问题。 创新和服务： 目标1：开发、维护和支持最先进的定量图像采集和 临床前和人体肌肉骨骼组织的重建方法。 目标2：开发新的图像分级和定量分析，并提供模板、培训和 实施可靠的放射照片、CT和MR图像临床分级措施以及软件 用于后处理、可视化和定量分析的软件包。 目标3：提供单次和系列成像检查的成像数据的解释，并评估 与提取的生化、组织学和生物力学测量的链接以及相关的临床 或实验终端。 教育和传播：总体目标将是促进发展和采用国家 肌肉骨骼研究中最先进的成像方法学。 目标4：提供对使用成像端点的先前研究的示例的Web门户访问 以及临床和研究影像服务的详细说明，并处理新的服务请求 通过门户网站高效运行。 目标5：开展积极主动的推广活动，吸引潜在的新用户并参加CCMBM研讨会 提供成像研讨会、研讨会和设施参观的活动，以介绍新的成像和 向CCMBM社区提供图像处理能力，特别关注初级和早期阶段 调查人员。

The goal of the Imaging Core is to provide state-of-the-art, customized image acquisition, reconstruction, and quantitative analysis for pre-clinical (tissue samples and animal models) and in vivo human musculoskeletal research. These will include pre-clinical and clinical: 1) acquisition and reconstruction of MRI/MRSI, PET, SPECT, CT, and optical tomography data; 2) spatial registration of multi-modality images; 3) extraction of quantitative information concerning biologically relevant image parameters; and 4) evaluation of the relationships of these imaging-derived parameters to biochemistry, histology, biomechanics, and physiology of biological systems interacting with the musculoskeletal system. Many of these procedures are novel and require specialized knowledge of imaging physics and mathematics. Investigators linked to the Imaging Core have extensive experience in these imaging and quantitative analysis techniques and will work closely with CCMBM investigators to match and/or develop the best imaging and data processing methods to their specific research questions. Innovation and Service: Aim 1: To develop, maintain, and support state-of-the-art quantitative image acquisition and reconstruction methods for pre-clinical and human musculoskeletal tissues. Aim 2: To develop novel image grading and quantitative analysis and to provide templates, training, and implement robust measures for clinical grading of radiographs, CT and MR images, and software packages for post-processing, visualization, and quantitative analysis. Aim 3: To provide interpretation of imaging data from single and serial imaging examinations and assess links to biochemical, histological, and biomechanical measures that are extracted and the relevant clinical or experimental endpoints. Education and Dissemination: The overarching goal will be to promote development and adoption of state-of- the-art imaging methodology in musculoskeletal research. Aim 4: To provide web portal access to examples of previous studies that have used imaging endpoints and detailed descriptions of clinical and research imaging services, and to handle new service requests efficiently though the web portal. Aim 5: To perform proactive outreach to attract potential new users and participate in CCMBM seminar activities to provide imaging seminars, workshops, and facilities tours that will introduce new imaging and image processing capabilities to the CCMBM community, with particular focus on junior and early stage investigators.