Imaging Core

成像核心

• 批准号: 10642794
• 负责人: GALATEIA J KAZAKIA
• 金额: $ 11.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10642794
• 关键词: Adoption; Animal Model; Biochemical; Biochemistry; Biology; Biomechanics; Body Composition; Cartilage; Clinical; Collaborations; Communities; Computer software; Consultations; Data; Development; Disease; Education; Educational workshop; Evaluation; Goals; Grant; Histologic; Histology; Human; Image; Image Analysis; Individual; Investigation; Knowledge; Link; Magnetic Resonance Imaging; Maps; Mathematics; Measures; Medicine; Methodology; Methods; Minor; Mission; Multimodal Imaging; Muscle; Musculoskeletal; Musculoskeletal System; Optical Tomography; Physics; Physiology; Positron-Emission Tomography; Procedures; Relaxation; Research; Research Personnel; Services; Structure; Students; Suggestion; Techniques; Technology; Texture; Tissue Sample; Tissues; Training; Visualization; Visualization software; Work; X-Ray Computed Tomography; biological systems; bone; clinically relevant; computerized data processing; cortical bone; design; experience; image processing; imaging capabilities; imaging informatics; in vivo; innovation; interest; magnetic resonance spectroscopic imaging; morphometry; novel; novel imaging technology; outreach; pre-clinical; quantitative imaging; reconstruction; serial imaging; single photon emission computed tomography; statistics; substantia spongiosa; tool; web portal

The goal of the Imaging Core is to provide state-of-the-art, customized image acquisition, reconstruction, and quantitative analysis for pre-clinical (tissue samples and animal models) and in vivo human musculoskeletal research. These will include pre-clinical and clinical: 1) acquisition and reconstruction of MRI/MRSI, PET, SPECT, CT, and optical tomography data; 2) spatial registration of multi-modality images; 3) extraction of quantitative information concerning biologically relevant image parameters; and 4) evaluation of the relationships of these imaging-derived parameters to biochemistry, histology, biomechanics, and physiology of biological systems interacting with the musculoskeletal system. Many of these procedures are novel and require specialized knowledge of imaging physics and mathematics. Investigators linked to the Imaging Core have extensive experience in these imaging and quantitative analysis techniques and will work closely with CCMBM investigators to match and/or develop the best imaging and data processing methods to their specific research questions. Innovation and Service: Aim 1: To develop, maintain, and support state-of-the-art quantitative image acquisition and reconstruction methods for pre-clinical and human musculoskeletal tissues. Aim 2: To develop novel image grading and quantitative analysis and to provide templates, training, and implement robust measures for clinical grading of radiographs, CT and MR images, and software packages for post-processing, visualization, and quantitative analysis. Aim 3: To provide interpretation of imaging data from single and serial imaging examinations and assess links to biochemical, histological, and biomechanical measures that are extracted and the relevant clinical or experimental endpoints. Education and Dissemination: The overarching goal will be to promote development and adoption of state-of- the-art imaging methodology in musculoskeletal research. Aim 4: To provide web portal access to examples of previous studies that have used imaging endpoints and detailed descriptions of clinical and research imaging services, and to handle new service requests efficiently though the web portal. Aim 5: To perform proactive outreach to attract potential new users and participate in CCMBM seminar activities to provide imaging seminars, workshops, and facilities tours that will introduce new imaging and image processing capabilities to the CCMBM community, with particular focus on junior and early stage investigators.

Imaging Core的目标是提供最先进的定制图像采集、重建 用于临床前（组织样品和动物模型）和体内人体的定量分析 肌肉骨骼研究这些将包括临床前和临床：1）采集和重建 MRI/MRSI、PET、SPECT、CT和光学断层扫描数据; 2）多模态图像的空间配准; 3） 提取关于生物学相关图像参数的定量信息;以及4）评估 这些成像衍生参数与生物化学、组织学、生物力学和 与肌肉骨骼系统相互作用的生物系统的生理学。其中许多程序是 新颖，需要成像物理学和数学的专业知识。调查人员与 Imaging Core在这些成像和定量分析技术方面拥有丰富的经验， 与CCMBM研究人员密切合作，匹配和/或开发最佳成像和数据处理方法， 具体的研究问题。 创新与服务： 目标1：开发、维护和支持最先进的定量图像采集， 临床前和人体肌肉骨骼组织的重建方法。 目标2：开发新的图像分级和定量分析，并提供模板，培训， 为X光片、CT和MR图像以及软件的临床分级实施稳健的措施 用于后处理、可视化和定量分析的软件包。 目的3：提供单次和连续成像检查的成像数据解释，并评估 链接到提取的生物化学、组织学和生物力学测量以及相关的临床 或实验终点。 教育和传播：总体目标将是促进发展和采用 肌肉骨骼研究中最先进的成像方法。 目的4：提供门户网站访问既往使用成像终点的研究示例 以及临床和研究影像服务的详细说明，并处理新的服务请求 有效地通过门户网站。 目标5：主动开展外展活动，吸引潜在的新用户并参加CCMBM研讨会 提供成像研讨会、讲习班和设施图尔斯参观的活动，这些活动将介绍新的成像技术， 图像处理能力，以CCMBM社区，特别侧重于初级和早期阶段 investigators.