ACCORD Administrative Core

协议行政核心

• 批准号: 10460402
• 负责人: Uma Sundaram
• 金额: $ 64.95万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460402
• 关键词: Advisory Committees; Affect; Appalachian Region; Biomedical Research; Biometry; Budgets; Centers of Research Excellence; Clinical Sciences; Collaborations; Country; Development; Developmental Disabilities; Disease; Dyslipidemias; Evaluation; Expenditure; Extramural Activities; Faculty; Foundations; Funding; Future Generations; Goals; Grant; Growth; Human Resources; Hypertension; Individual; Infrastructure; Institutes; Institution; Interdisciplinary Study; International; Kentucky; Manuscripts; Mentors; Mission; Molecular; Monitor; Morbidity - disease rate; Obesity; Obesity Epidemic; Outcome; Patient Care; Phase; Physiology; Policies; Positioning Attribute; Preparation; Primary Health Care; Procedures; Recommendation; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Scientific Evaluation; Scourge; Supervision; Time; Training; Translating; Translational Research; Transport Process; United States National Institutes of Health; Universities; Vision; West Virginia; Workforce Development; base; career; career development; cell growth regulation; clinical center; faculty research; graduate student; health care disparity; improved; innovation; medical schools; meetings; mortality; next generation; programs; prospective; tumor; undergraduate student

The overall goal of the Administrative Core of the Center for Biomedical Research Excellence (COBRE) Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) at the Marshall University School of Medicine (MUSOM) is to provide administrative oversight for the career development of ACCORD investigators as well as growth and sustainability of Center infrastructure. We envision the creation of a national center of excellence to promote cellular transport physiology in obesity related disorders at MUSOM, as this institution is at the epicenter of the obesity epidemic of this region. The emphasis of biomedical research will be on cellular and molecular transport abnormalities in obesity associated conditions such as dyslipidemia, hypertension, certain tumors and developmental disabilities. A comprehensive plan for administrative, fiscal, and scientific support will be established and implemented to assure appropriate supervision and direction of ACCORD. A robust plan for individual and group mentoring will be implemented as a foundational component of this COBRE. Mentoring will encompass all aspects of development of junior investigators including, but not limited to, management of lab finances and personnel, meeting individual time- framed research goals, preparation of manuscripts and presentations, development of extramural grants including R01 level funding proposals, and any additional individualized needs as identified. The expected outcome is successful acquisition of R01 NIH funding to sustain and build upon the research foundations that are already established. To further advance the research capacity, ACCORD will closely interact with existing resources (e.g., WV INBRE, UK/MU CTSA), and establish new programs. These will include 1. the Biostatistics and Study Design preCore and Mentoring and Workforce Development preCore that will be grown during phase I to become a full Cores in Phase II of this COBRE; and, 2. Pilot funding to enhance molecular and intracellular regulation of cellular transport in obesity related disorders. Finally, formative and summative evaluation of scientific integrity, progress, and accomplishments of ACCORD will be regularly conducted in a comprehensive manner. Based on results and advice of the Internal Advisory Committee (including its Executive Committee) and External Advisory Committee, appropriate corrective steps, as well as prospective steps to advance the mission of the ACCORD COBRE, will be regularly instituted. With this innovative and much needed Appalachian region program, we will train the next generation of investigators to conduct cellular transport research in obesity which contributes to much of the health care disparities not only in WV, but also in many other regions of this country.

生物医学研究卓越中心（COBRE）的管理核心的总体目标 马歇尔大学阿巴拉契亚肥胖相关疾病细胞转运中心（雅阁） 医学院（MUSOM）将为雅阁的职业发展提供行政监督 调查人员以及中心基础设施的增长和可持续性。我们设想创造一个 国家卓越中心，以促进肥胖相关疾病的细胞转运生理学， 因为这个机构是这个地区肥胖流行病的中心。生物医学的重点 将研究肥胖相关疾病中的细胞和分子转运异常， 血脂异常、高血压、某些肿瘤和发育障碍。的全面计划 将建立和实施行政、财政和科学支持，以确保适当的 雅阁的监督和指导。将实施一项强有力的个人和团体辅导计划 作为眼镜蛇的基础组件指导将涵盖初级发展的各个方面 研究人员，包括但不限于实验室财务和人员管理，会议个人时间- 制定研究目标，准备手稿和报告，发展校外赠款 包括R 01级供资提案，以及确定的任何其他个性化需求。预期 结果是成功获得R 01 NIH资金，以维持和建立研究基础， 已经建立。为了进一步提高研究能力，雅阁将与现有的 资源（例如，WV INBRE，UK/MU CTSA），并建立新的方案。这些将包括1。生物统计 以及研究设计preCore和指导与劳动力发展preCore，这些preCore将在 第一阶段成为该COBRE第二阶段的完整核心;以及，2。试点供资，以加强分子和 肥胖相关疾病中细胞转运的细胞内调节。最后，形成性和总结性 将定期对雅阁的科学完整性、进展和成就进行评估 全面的方式。根据内部咨询委员会（包括其 执行委员会）和外部咨询委员会，适当的纠正措施，以及预期的 将定期采取措施推进雅阁COBRE的使命。通过这种创新和 急需的阿巴拉契亚地区计划，我们将培训下一代调查人员进行细胞 肥胖症的运输研究不仅在西弗吉尼亚州，而且在 这个国家的许多其他地区。