Core B - Training Core

MDSRC培训核心的总体目标是增加经过严格训练和科学能力强的研究人员的数量，这些研究人员能够在肌肉萎缩症方面维持富有成效的基础科学、转化和/或临床研究项目。为了实现这一核心目标，核心将确定和招募对肌肉萎缩症的独立基础科学、转化和/或临床研究表现出真正兴趣和潜力的合格基础科学和临床博士前和博士后候选人。将特别强调从种族、族裔、性别、社会经济地位和残疾方面人数不足的群体征聘受训人员。培训核心和相关配套资金将同时支持MDSRC学院实验室至少三名博士前实习生，外加至少一名博士后实习生和一名临床实习生。佛罗里达大学和加州大学洛杉矶分校的培训中心将监督和协调由核心基金和配套基金支持的学员以及MDSRC项目支持的研究人员实验室中从事肌肉萎缩症研究的博士前、博士后和临床研究员的一系列培训活动。每位受训者将根据他们过去的培训以及他们的主要导师和论文委员会的建议，准备一份个人发展计划。根据受训者的职业阶段，个性化计划可能包括结构化的教学计划、研讨会和指导的拨款写作经验。所有博士预科学员将被要求在各自的机构注册涵盖肌肉健康和疾病、拨款写作和负责任的研究行为的课程。临床研究的学员将进一步被要求参加与临床试验的设计和实施有关的课程。佛罗里达大学和加州大学洛杉矶分校都提供关于肌肉萎缩症的专门课程——佛罗里达大学的肌肉萎缩症和肌病，加州大学洛杉矶分校的肌肉萎缩症的机制和治疗。加州大学洛杉矶分校的课程是完全在线的，加州大学系统内外的任何学生都可以使用，佛罗里达大学的课程录制将于2021年春季完成，并向三个地点的学员开放。培训中心将通过以下方式进一步改善培训环境：1)在佛罗里达大学和加州大学洛杉矶分校举办年度学员研讨会；2)前往参加NCH/OSU年度Myology课程；对于参加课程的学员，将为来自佛罗里达大学、加州大学洛杉矶分校和西北大学的学员举办学员介绍晚会；3)前往韦尔斯通中心展示肌肉生物学和疾病新方向（新方向）国际会议。此外，MDSRC中心将继续组织两场以肌肉健康和疾病为重点的国际会议——新方向会议和健康与疾病中的骨骼肌生物学进展会议。在新方向会议上，培训中心将为不同Wellstone中心的学员举办培训数据闪电战，以促进互动和数据共享。

Project Summary/Abstract The overall objective of the MDSRC Training Core is to increase the number of rigorously trained and scientifically competent researchers capable of sustaining productive basic science, translational and/or clinical research programs in muscular dystrophy. To meet this central objective, the core will identify and recruit qualified basic science and clinical predoctoral and postdoctoral candidates who demonstrate a genuine interest in, and potential for, independent basic science, translational and/or clinical research in muscular dystrophy. Particular emphasis will be placed on the recruitment of trainees from underrepresented groups with respect to race, ethnicity, gender, socio-economic status and disabilities. The Training Core and associated matching funds will support at least three predoctoral trainees in MDSRC faculty labs at any one time, plus at least one postdoctoral trainee and one clinical trainee. The Training Cores at UF and UCLA will oversee and coordinate a spectrum of training activities for trainees supported by the core and matching funds, as well as the predoctoral, postdoctoral and clinical fellow researchers engaged in muscular dystrophy research in the labs of researchers supported through the projects of the MDSRC. Each trainee will prepare an Individual Development Plan, based on their past training and recommendations from their primary mentor and thesis committee. Depending on the career stage of the trainee, the individualized plan may consist of a structured didactic program, seminars, and mentored grant writing experiences. All predoctoral trainees will be required to enroll in courses at their respective institutions that cover muscle health and disease, grant writing and responsible conduct of research. Trainees in clinical research will further be required to enroll in courses related to the design and conduct of clinical trials. Both UF and UCLA offer specific courses on muscular dystrophies - Muscular Dystrophy and Myopathies at UF and Mechanisms and Therapies for Muscular Dystrophies at UCLA. The UCLA course is fully online and available to any student across the University of California system and beyond, and the UF course recording will be complete in Spring 2021, and made available to trainees across the three sites. The Training Cores will further enhance the training environment by supporting 1) annual trainee hosted seminars at UF and UCLA, 2) travel to attend the Annual NCH/OSU Myology Course and, for those attending the course, a trainee presentation evening for trainees from UF, UCLA and NU and, 3) travel to present at our Wellstone Center aligned New Directions in Muscle Biology and Disease (New Directions) international conference. In addition, the MDSRC Center will continue to organize two international conferences focused on muscle health and disease – the New Directions Conference, and Advances in Skeletal Muscle Biology in Health & Disease Conference. At the New Directions Conference, the Training Core will host a Trainee Data Blitz for trainees across the different Wellstone Centers to facilitate interactions and data sharing.