Intervention Core for the Dietary Biomarkers Development Center at Harvard University

哈佛大学膳食生物标志物开发中心的干预核心

• 批准号: 10461133
• 负责人: FRANK M SACKS
• 金额: $ 63.98万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-16 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461133
• 关键词: Acute; Adult; Avena sativa; Behavior; Biological Markers; Biomarker of Dietary Intake; Blood; Bread; Catalogs; Chickens; Collaborations; Complement; Cotinine; Diet; Dietary Practices; Dietary intake; Disputes; Dose; Drug Kinetics; Eating; Epidemiology; Fasting; Food; Fostering; Frequencies; Goals; Grain; Health; Healthy Eating; Hospitals; Hour; Human; Institutes; Intervention; Life Style; Literature; Measurement; Measures; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Nutrient; Nutritional Study; Outcomes Research; Patient Self-Report; Plasma; Population; Population Heterogeneity; Population Study; Potato; Prevention strategy; Primary Prevention; Proteins; Public Health Schools; Questionnaires; Reporting; Research Design; Research Personnel; Resources; Sampling; Soybeans; Technology; Time; United States; United States Department of Agriculture; United States National Institutes of Health; Universities; Urine; Wheat; Work; base; beef; biomarker development; cigarette smoking; dietary; epidemiology study; feeding; food consumption; medical schools; metabolomics; novel; nutrition; population based; response; specific biomarkers; tool

ABSTRACT/SUMMARY – INTERVENTION CORE Diet is one of the most important determinants of human health and an essential component of population-wide primary prevention strategies. However, there is controversy about the quality and reliability of population- based nutrition research. Indeed, the vast majority of evidence for healthy eating is informed by large studies with dietary patterns assessed via self-report. Self-reported tools have well-recognized limitations. Plasma biomarkers have been a mainstay of epidemiologic studies. Recent advances in metabolomics technology has similarly fostered discovery of metabolites that are highly specific to intakes of foods or food groups. Metabolomics offers a tangible opportunity to identify novel metabolomic signatures for a range of foods and nutrients. However, this progress relies on the tremendous need for controlled feeding studies to identify and validate metabolites specific to each food item and group. Our objective is to establish an Intervention Core, equipped to perform tightly controlled pharmacokinetic and dose-response feeding studies across a range of food items and food groups in diverse populations. We will focus on common foods from the protein and grains food groups: (1) chicken, beef, and soybeans; and (2) whole wheat bread, potatoes, and oats. Based on our collective extensive work in nutrition metabolomics, we hypothesize that acute administration of these foods will have distinct metabolomics signatures that persist over an ensuing 24-hour period. Moreover, plasma concentrations of these metabolites will respond to the amount of the food consumed over a 6-day feeding period. Our long-term goal through these exemplar cases is to establish a rigorous and highly productive resource to the NIH, USDA, and external investigators to systematically catalog specific, reliable, and externally validated metabolomic signatures of nearly all commonly consumed foods in the United States. This proposal combines the nutrition, epidemiology, metabolomics, and feeding trials expertise of investigators at the Harvard T.H.Chan School of Public Health, the Broad Institute of Harvard and MIT, and Harvard Medical School affiliated hospitals to create a state-of-the-art nutrition-metabolomics center that will pave the way for a new era in nutrition research. Building on a long-track record of collaboration, this proposal will contribute novel, objective, metabolomic biomarkers for the characterization of diet in large population- based studies. Ultimately, this proposal answers the NIDDK and USDA’s call “for objective biomarkers of dietary intake that can serve as independent markers of dietary intake and complement current dietary intake assessment methods.”

摘要/总结 – 干预核心 饮食是人类健康最重要的决定因素之一，也是全民健康的重要组成部分 一级预防策略。然而，关于人口的质量和可靠性存在争议 基础营养研究。事实上，绝大多数健康饮食的证据都是来自大型研究 通过自我报告评估饮食模式。自我报告的工具具有众所周知的局限性。 血浆生物标志物一直是流行病学研究的支柱。代谢组学的最新进展 技术同样促进了对食物或食物摄入高度特异性的代谢物的发现 组。代谢组学提供了一个切实的机会来识别一系列新的代谢组学特征 食物和营养素。然而，这一进展依赖于控制喂养研究的巨大需求 识别并验证每种食品和类别的特定代谢物。 我们的目标是建立一个干预核心，能够执行严格控制的药代动力学和 对不同人群中的一系列食品和食品组进行剂量反应喂养研究。我们将 重点关注蛋白质和谷物类食物中的常见食物：（1）鸡肉、牛肉和大豆；和（2） 全麦面包、土豆和燕麦。基于我们在营养代谢组学方面的集体广泛工作，我们 假设急性摄入这些食物将具有持续存在的独特代谢组学特征 在随后的 24 小时内。此外，这些代谢物的血浆浓度将对 6 天喂养期间消耗的食物量。通过这些典型案例我们的长期目标 是为 NIH、USDA 和外部研究人员建立严格且高效的资源， 系统地对几乎所有的特定、可靠且经过外部验证的代谢组学特征进行分类 在美国普遍食用的食物。 该提案结合了营养学、流行病学、代谢组学和喂养试验的专业知识 哈佛大学陈曾熙公共卫生学院、哈佛大学和麻省理工学院博德研究所的研究人员，以及 哈佛医学院附属医院将创建最先进的营养代谢组学中心 为营养研究的新时代铺平道路。该提案建立在长期合作记录的基础上 将为大量人群的饮食特征提供新颖、客观的代谢组生物标志物 基础研究。最终，该提案回应了 NIDDK 和 USDA 的号召“寻找客观的生物标志物 膳食摄入量可以作为膳食摄入量的独立标志并补充当前膳食摄入量 评估方法。”