Adolescence and HIV SWG

项目总结/摘要 青春期和艾滋病毒SWG（SWG_2） 在美国，每年约有26%的艾滋病毒感染事件涉及青少年， 13-24岁的年轻人。在国际上，世界卫生组织估计，每两分钟 15-19岁的青少年感染艾滋病毒。青少年是全球和非洲艾滋病毒流行的主要驱动因素。 美国，强调迫切需要实施有效的预防方案， 检测服务和护理方案，促进长期参与护理， 持续的病毒抑制，从而避免耐药性。尽管有效的 艾滋病仍然是全世界青少年死亡的主要原因之一， 强调了让感染艾滋病毒的青少年接受持续护理的挑战，在某些情况下，这种护理要持续数十年 从婴儿早期开始此外，没有让性活跃的艾滋病毒感染青少年参与护理和 促进持续的病毒抑制增加了人口感染艾滋病毒的风险，并促进了 耐药HIV病毒株。提供尽可能好的艾滋病毒预防、护理和治疗服务， 青少年需要各种针对具体情况的、对青年敏感的办法。目前的研究由 哈佛大学艾滋病研究中心（HU CFAR）的调查人员包括广泛的预防范围， 艾滋病毒高危青少年、艾滋病毒感染者和艾滋病毒并发症患者的检测和护理方法 疾病和治疗。我们建议成立一个青少年和艾滋病毒科学工作组， HU CFAR将这些调查人员聚集在一起，有三个具体目标：1）促进参与 来自广泛的调查人员和公众社区的以预防为重点的艾滋病毒预防和护理研究 2）开发一个新的青少年艾滋病毒研究“工具包”，建立在HU的专业知识基础上 CFAR调查人员为青少年艾滋病毒的新调查人员提供方法学资源; 3）创建 并支持新的导师关系和新的以青少年艾滋病毒为重点的研究项目，扩大HU CFAR青少年艾滋病毒研究组合，并增加资助的早期职业调查员人数， 开展青少年艾滋病毒工作。通过建立一个青少年和艾滋病毒科学工作组，我们计划 促进跨学科参与以艾滋病为重点的艾滋病毒研究， 方法学资源，并扩大胡CFAR组合的研究为中心。借力 哈佛大学CFAR和更广泛的CFAR和波士顿科学界的优势，我们将 促进新的合作，特别强调促进早期职业调查员， 与DPH合作。因此，HU CFAR青少年和艾滋病毒工作组可以制定创新方法， 影响关键弱势群体的关键问题：感染艾滋病毒和面临感染风险的青少年和年轻人 艾滋病。

PROJECT SUMMARY/ABSTRACT Adolescence and HIV SWG (SWG_2) In the United States, approximately 26% of all incident HIV infections annually have involved adolescents and young adults aged 13-24. Internationally, the World Health Organization estimates that every two minutes an adolescent aged 15-19 acquires HIV. Adolescents are key drivers of the HIV epidemic both globally and in the United States, highlighting the urgent need to implement efficacious prevention programs, youth-friendly testing services, and care programming that promotes long-term engagement in care with achievement of sustained viral suppression and thus avoidance of drug resistance. Despite the availability of effective treatment options, AIDS remains one of the leading causes of death among adolescents worldwide, highlighting the challenges of engaging adolescents with HIV in sustained care, in some cases, for decades beginning in early infancy. Furthermore, failure to engage sexually active adolescents with HIV in care and promote sustained viral suppression increases population risk of HIV acquisition and promotes transmission of resistant HIV viral strains. Providing the best possible HIV prevention and care and treatment services for adolescents requires a wide range of setting-specific, youth-responsive approaches. Current research by Harvard University Center for AIDS Research (HU CFAR) investigators includes a broad scope of prevention, testing, and care approaches for adolescents at risk for HIV and those living with HIV and complications of HIV disease and treatment. We propose to develop an Adolescence & HIV Scientific Working Group (SWG) within the HU CFAR to bring these investigators together, with three specific aims: 1) To promote participation in adolescent-focused HIV prevention and care research from a broad community of investigators and public health organizations; 2) To develop a novel adolescent HIV research “tool kit,” building on the expertise of HU CFAR investigators to provide methodologic resources for investigators new to adolescent HIV; 3) To create and support new mentorship relationships and new adolescent HIV-focused research projects, expand the HU CFAR adolescent HIV research portfolio, and increase the number of Early Career Investigators funded to conduct adolescent HIV work. By creating an Adolescence & HIV Scientific Working Group, we plan to promote interdisciplinary engagement in adolescent-focused HIV research, provide adolescent-specific methodologic resources, and expand the HU CFAR portfolio of adolescent-centered research. Leveraging the strengths of the Harvard University CFAR and the broader CFAR and Boston scientific communities, we will catalyze new collaborations, with particular emphasis on promoting Early Career Investigators and partnerships with DPH. The HU CFAR Adolescent & HIV SWG can thus generate innovative approaches to critical questions impacting a key vulnerable population: adolescents and young adults with HIV and at risk of HIV.