Memory fragmentation during threat-driven naturalistic events

项目摘要/摘要 威胁作为一种行为和神经结构会影响记忆质量。动物模型显示与唤醒相关 MTL功能障碍，与人类神经成像文献中的同源。具体地说，高唤醒偏向 在损害海马体上下文绑定的情况下对基于项目的处理进行记忆编码， 导致记忆碎片化。使用自然主义刺激(即电影剪辑)的研究允许现实 刻画诱发威胁驱动的情景记忆和随后的准确唤醒的影响 功能障碍；然而，MTL的功能参与的作用在 唤醒驱动事件的编码和检索。拟议的研究将利用生态上有效的实验 使用自然事件记忆进行编码和检索时基于任务的成像技术设计 以及不受约束的自由回忆，以更好地模拟现实世界的背景。这项提议将提供一种神经生物学 为识别由于威胁相关的唤醒而导致的记忆偏差奠定了基础。此外，这一项目和研究金将 允许我获得关键的培训机会，特别是在神经成像分析、统计建模和 对综合记忆和神经调节的认知神经科学的理论理解 如果没有这笔资金，我就没有时间收到这笔钱。我的导师，共同导师和我 设计了一个训练计划，使我能够将动物模型转化为人类神经成像研究，以及 掌握应用这些方法的技能，为理解威胁相关的唤醒偏向提供框架 记忆内聚力。此外，通过这些经验，我将掌握所需的分析技术来表征 基于任务的成像研究设计的神经行为相关性。这些努力将确保我获得 专业、分析和理论技能是我未来成为一名独立调查员所必需的 与唤醒相关的记忆领域。这笔奖学金的支持将使我能够完成我的学业。 并发展成为多产和有影响力的研究人员，识别与威胁相关的神经机制 唤醒对自然记忆形成和记忆碎片化的影响，我希望将其应用于模型 未来的创伤后应激障碍。

PROJECT SUMMARY/ABSTRACT Threat as a behavioral and neural construct impacts memory quality. Animal models show arousal-related dysfunction of the MTL, with homologs in the human neuroimaging literature. Specifically, high arousal biases memory encoding towards item-based processing at the detriment of contextual binding in the hippocampus, leading towards memory fragmentation. Research using naturalistic stimuli (i.e., movie clips) allows realistic portrayal to induce threat-driven episodic memory and subsequent impact of accurate arousal-induced dysfunction; however, the role of functional engagement of the MTL have not been wholly identified during the encoding and retrieval of arousal-driven events. The proposed study will utilize ecologically valid experimental designs of tasked-based imaging techniques during encoding and retrieval using naturalistic event memoranda and unconstrained free recall, to better model real-world contexts. This proposal will provide a neurobiological foundation to identify biases in memory due to threat-related arousal. Further, this project and fellowship would allow me to obtain key training opportunities, particularly in neuroimaging analysis, statistical modeling, and theoretical understanding of synthesizing the cognitive neuroscience of memory and neuromodulation; all of which I would not otherwise have the time to receive without this funding. My mentor, co-mentor and I have designed a training plan that will allow me to translate animal models into human neuroimaging research, and gain skills to apply these methods to provide frameworks to understand how threat-related arousal biases memory cohesion. Further, through these experiences I will master analysis techniques needed to characterize neurobehavioral correlates of task-based imaging study designs. These efforts will ensure I gain the professional, analytical, and theoretical skills necessary for my future career as an independent investigator in the domain of arousal-related memory. The support of this fellowship will allow me to round out my education and develop into a productive and impactful researcher, identifying neural mechanisms for threat-related arousal impacts on natural memory formation and memory fragmentation, which I will hope to apply to models of PTSD in the future.