Memory fragmentation during threat-driven naturalistic events
威胁驱动的自然事件期间的内存碎片
基本信息
- 批准号:10670678
- 负责人:
- 金额:$ 3.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-30 至 2024-06-29
- 项目状态:已结题
- 来源:
- 关键词:Amygdaloid structureAnimal ModelAnimalsArousalBehavioralBehavioral ParadigmBindingCell NucleusChargeClipComplexDataDevelopmentEducationEmotionalEnsureEnvironmentEpisodic memoryEventExperimental DesignsFellowshipFoundationsFunctional Magnetic Resonance ImagingFunctional disorderFundingFutureGoalsHeart RateHippocampusHomologous GeneHourHumanImageImaging TechniquesIndividualLaboratoriesLiteratureMeasuresMedialMemoryMentorsMethodsModelingNeurobiologyPhysiologicalPost-Traumatic Stress DisordersPredispositionProcessProductivityResearchResearch DesignResearch PersonnelRetrievalRoleStatistical ModelsStimulusStructureSystemTechniquesTemporal LobeTestingTimeTrainingTranslatingarchived datacareercognitive neurosciencecohesiondesignexperienceimaging studyinformation processinginsightlocus ceruleus structuremembermemory encodingmovieneuralneurobehavioralneuroimagingneuromechanismneurophysiologyneuroregulationnoradrenergicnovelresponsescaffoldskillsspatiotemporaltraining opportunity
项目摘要
PROJECT SUMMARY/ABSTRACT
Threat as a behavioral and neural construct impacts memory quality. Animal models show arousal-related
dysfunction of the MTL, with homologs in the human neuroimaging literature. Specifically, high arousal biases
memory encoding towards item-based processing at the detriment of contextual binding in the hippocampus,
leading towards memory fragmentation. Research using naturalistic stimuli (i.e., movie clips) allows realistic
portrayal to induce threat-driven episodic memory and subsequent impact of accurate arousal-induced
dysfunction; however, the role of functional engagement of the MTL have not been wholly identified during the
encoding and retrieval of arousal-driven events. The proposed study will utilize ecologically valid experimental
designs of tasked-based imaging techniques during encoding and retrieval using naturalistic event memoranda
and unconstrained free recall, to better model real-world contexts. This proposal will provide a neurobiological
foundation to identify biases in memory due to threat-related arousal. Further, this project and fellowship would
allow me to obtain key training opportunities, particularly in neuroimaging analysis, statistical modeling, and
theoretical understanding of synthesizing the cognitive neuroscience of memory and neuromodulation; all of
which I would not otherwise have the time to receive without this funding. My mentor, co-mentor and I have
designed a training plan that will allow me to translate animal models into human neuroimaging research, and
gain skills to apply these methods to provide frameworks to understand how threat-related arousal biases
memory cohesion. Further, through these experiences I will master analysis techniques needed to characterize
neurobehavioral correlates of task-based imaging study designs. These efforts will ensure I gain the
professional, analytical, and theoretical skills necessary for my future career as an independent investigator in
the domain of arousal-related memory. The support of this fellowship will allow me to round out my education
and develop into a productive and impactful researcher, identifying neural mechanisms for threat-related
arousal impacts on natural memory formation and memory fragmentation, which I will hope to apply to models
of PTSD in the future.
项目总结/文摘
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Franklin Gregory其他文献
David Franklin Gregory的其他文献
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{{ truncateString('David Franklin Gregory', 18)}}的其他基金
Memory fragmentation during threat-driven naturalistic events
威胁驱动的自然事件期间的内存碎片
- 批准号:
10462905 - 财政年份:2022
- 资助金额:
$ 3.57万 - 项目类别:
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