FASEB SRC: The Ubiquitin & Ub-like proteins Conference: Cell Functions and Therapeutic Targeting

摘要/摘要 2022年FASEB夏季泛素和类Ub蛋白研究会议：细胞功能和 治疗靶向将在南桥酒店和会议中心举行， 马萨诸塞州，2022年7月24日至7月28日。这个由FASEB主办的会议每两年举行一次 自1989年以来；此申请寻求对2022年会议的支持，该会议因新冠肺炎而从 2020年。会议将汇集约150名研究人员(初级和高级科学家， 博士后研究员、研究生以及来自行业和政府的人士)，以了解最近 泛素(UB)和泛素样蛋白(UBL)调控蛋白降解和信号转导的研究进展 修改，特别强调人类疾病。蛋白质泛素化涉及生物学的所有领域 其影响的多样性怎么强调都不为过。泛素对蛋白质的选择性降解 系统是一种控制真核细胞生物学几乎所有方面的机制，包括细胞周期， 转录、代谢途径、发育和抗原处理。此外，非蛋白水解性功能 泛素化和UBL修饰在蛋白质运输和信号转导中是关键的过程，涉及 先天免疫系统中的膜受体和信号，而其他有助于协调DNA 损坏反应。该系统的功能障碍涉及许多疾病过程，特别是癌症， 神经和发育疾病，以及病毒和微生物感染性疾病。此外，Ub和Ubl 蛋白质在传染病中是至关重要的，现在很明显，微生物编码UBL蛋白质， 细菌和病毒产生酶来调节和/或模仿宿主的细胞泛素化途径 细胞，而这些细胞通过特定的UBL蛋白保护自己免受传染病的侵袭。八个主题 科学会议将是：(I)泛素结合和去结合的机制；(Ii)分子机器； (Iii)疾病病理学；(Iv)类Ub蛋白和非典型泛素；(V)蛋白质质量控制和应激；(Vi) 细胞器和途径；(Vii)治疗靶向；()信号通路和细胞命运。此外, 将有两个海报会议和一个以职业发展为重点的专家讨论小组会议。 在这一迅速发展的研究领域，这次会议将是一次及时而重要的会议。它的独特之处在于 它提供了一种形式，将范围非凡的调查人员聚集在一起，他们的集体方法 包括细胞生物学、生化、结构生物学、分子和遗传学方法 细胞增殖和信号通路调控中的问题。FASEB SRC格式提供了 安全和包容的环境，鼓励与会者之间进行非正式和开放的讨论，并 反过来，促进合作努力的发起，并刺激未来的研究方向，以拓宽 了解UB、蛋白酶体和UBL蛋白在健康和疾病中的作用。

Summary/Abstract The 2022 FASEB Summer Research Conference on Ubiquitin & Ub-like proteins: Cell Functions and Therapeutic Targeting will be held at the Southbridge Hotel and Conference Center, Southbridge, Massachusetts, July 24th to July 28th, 2022. This FASEB-sponsored conference has been held biannually since 1989; this application seeks support for the 2022 conference, which was delayed due to COVID-19 from 2020. The conference will bring together approximately 150 investigators (junior and senior scientists, postdoctoral fellows, graduate students, and people from industry and government) for discussions of recent advances in the areas of regulated proteolysis and signaling by ubiquitin (UB) and ubiquitin-like (UBL) protein modification, with special emphasis on human diseases. Protein ubiquitination cuts across all fields of biology and the diversity of its impacts cannot be overstated. The selective degradation of proteins by the ubiquitin system is a mechanism for control of virtually all aspects of eukaryotic cell biology, including the cell cycle, transcription, metabolic pathways, development, and antigen processing. In addition, non-proteolytic functions of ubiquitination and UBL modification in protein trafficking and signaling are critical for processes that involve membrane receptors and signaling in the innate immune system, while others help to coordinate the DNA damage response. Dysfunction of the system is involved in many disease processes, particularly cancer, neurologic and developmental diseases, and viral and microbial infectious diseases. In addition, UB and UBL proteins are critical in infectious diseases, and it is now evident that microbes encode UBL proteins, that bacteria and viruses produce enzymes to modulate and/or emulate cellular ubiquitination pathways in host cells, and that cells defend themselves against infectious agents with specific UBL proteins. The topics of eight scientific sessions will be: (i) Mechanism of Ubiquitin Conjugation & Deconjugation; (ii) Molecular Machines; (iii) Disease Pathology; (iv) Ub-like Proteins and Atypical Ubiquitin; (v) Protein Quality Control and Stress; (vi) Organelles and Pathways; (vii) Therapeutic Targeting; (viii) Signaling Pathways and Cell Fate. In addition, there will be two poster sessions and a Meet the Experts discussion panel focused on career development. This conference will be a timely and important meeting in this rapidly growing research area. It is unique in that it provides a format that brings together an extraordinary range of investigators whose collective approaches encompass cell biological, biochemical, structural biology, molecular and genetic methods that address central issues in the regulation of cellular proliferation and signaling pathways. The FASEB SRC format provides a safe and inclusive environment that encourages informal and open discussions among the participants and this in turn fosters initiation of collaborative efforts and stimulates future research directions to broaden the understanding of the roles of UB, the proteasome, and UBL proteins in health and disease.