FASEB SRC: The Ubiquitin & Ub-like proteins Conference: Cell Functions and Therapeutic Targeting

摘要/摘要 2022 FASEB Summer Research Conference on Ubiquitin & Ub-like Proteins：Cell Functions and 治疗靶向将在南桥酒店和会议中心举行，南桥， 马萨诸塞州，2022年7月24日至7月28日。这个由FASEB主办的会议每两年举行一次 自1989年以来，该应用程序寻求对2022年会议的支持，该会议因COVID-19而推迟， 2020.会议将汇集大约150名研究人员（初级和高级科学家， 博士后研究员，研究生，以及来自行业和政府的人士）讨论最近的 泛素（UB）和泛素样（UBL）蛋白调控蛋白水解和信号传导的研究进展 修改，特别强调人类疾病。蛋白质泛素化跨越了生物学的所有领域 其影响的多样性怎么强调都不为过。泛素选择性降解蛋白质 系统是控制真核细胞生物学的几乎所有方面的机制，包括细胞周期， 转录、代谢途径、发育和抗原加工。此外，非蛋白水解功能 泛素化和UBL修饰在蛋白质运输和信号传导中的作用对于涉及 膜受体和信号在先天免疫系统，而其他人帮助协调DNA 损伤响应该系统的功能障碍涉及许多疾病过程，特别是癌症， 神经和发育疾病以及病毒和微生物感染性疾病。此外，UB和UBL 蛋白质在感染性疾病中至关重要，现在很明显，微生物编码UBL蛋白， 细菌和病毒产生酶以调节和/或模拟宿主中的细胞泛素化途径 细胞，并且细胞用特定的UBL蛋白质来保护自己免受感染剂的侵害。八个主题 科学会议将包括：（i）泛素结合和去结合的机制;（ii）分子机器; (iii)疾病病理学;（iv）Ub样蛋白和非典型泛素;（v）蛋白质质量控制和应激;（vi） 细胞器和途径;（vii）治疗靶向;（viii）信号传导途径和细胞命运。此外，本发明还提供了一种方法， 将有两个海报会议和一个专家会议讨论小组，重点是职业发展。 这次会议将是这个快速发展的研究领域的一次及时而重要的会议。它的独特之处在于， 它提供了一种形式，汇集了一个非凡的调查人员，他们的集体方法， 包括细胞生物学、生物化学、结构生物学、分子和遗传学方法， 细胞增殖和信号传导途径的调节问题。FASEB SRC格式提供了 安全和包容的环境，鼓励参与者之间进行非正式和公开的讨论， 反过来又促进合作努力的启动，并刺激未来的研究方向，以扩大 了解UB、蛋白酶体和UBL蛋白在健康和疾病中的作用。

Summary/Abstract The 2022 FASEB Summer Research Conference on Ubiquitin & Ub-like proteins: Cell Functions and Therapeutic Targeting will be held at the Southbridge Hotel and Conference Center, Southbridge, Massachusetts, July 24th to July 28th, 2022. This FASEB-sponsored conference has been held biannually since 1989; this application seeks support for the 2022 conference, which was delayed due to COVID-19 from 2020. The conference will bring together approximately 150 investigators (junior and senior scientists, postdoctoral fellows, graduate students, and people from industry and government) for discussions of recent advances in the areas of regulated proteolysis and signaling by ubiquitin (UB) and ubiquitin-like (UBL) protein modification, with special emphasis on human diseases. Protein ubiquitination cuts across all fields of biology and the diversity of its impacts cannot be overstated. The selective degradation of proteins by the ubiquitin system is a mechanism for control of virtually all aspects of eukaryotic cell biology, including the cell cycle, transcription, metabolic pathways, development, and antigen processing. In addition, non-proteolytic functions of ubiquitination and UBL modification in protein trafficking and signaling are critical for processes that involve membrane receptors and signaling in the innate immune system, while others help to coordinate the DNA damage response. Dysfunction of the system is involved in many disease processes, particularly cancer, neurologic and developmental diseases, and viral and microbial infectious diseases. In addition, UB and UBL proteins are critical in infectious diseases, and it is now evident that microbes encode UBL proteins, that bacteria and viruses produce enzymes to modulate and/or emulate cellular ubiquitination pathways in host cells, and that cells defend themselves against infectious agents with specific UBL proteins. The topics of eight scientific sessions will be: (i) Mechanism of Ubiquitin Conjugation & Deconjugation; (ii) Molecular Machines; (iii) Disease Pathology; (iv) Ub-like Proteins and Atypical Ubiquitin; (v) Protein Quality Control and Stress; (vi) Organelles and Pathways; (vii) Therapeutic Targeting; (viii) Signaling Pathways and Cell Fate. In addition, there will be two poster sessions and a Meet the Experts discussion panel focused on career development. This conference will be a timely and important meeting in this rapidly growing research area. It is unique in that it provides a format that brings together an extraordinary range of investigators whose collective approaches encompass cell biological, biochemical, structural biology, molecular and genetic methods that address central issues in the regulation of cellular proliferation and signaling pathways. The FASEB SRC format provides a safe and inclusive environment that encourages informal and open discussions among the participants and this in turn fosters initiation of collaborative efforts and stimulates future research directions to broaden the understanding of the roles of UB, the proteasome, and UBL proteins in health and disease.