Origin of Chronic Diseases of Aging Among Rural African American Young Adults

项目总结 目前的建议建立在一项正在进行的调查的基础上，以测试关于(1)的作用的假设 “老化”的年轻身体中的心理社会应激源，(2)可能减轻其不利影响的保护因素 影响，以及(3)在关键的生命过程转变过程中，连续性和变化在风化过程中的作用。测试 这些假设将有助于更好地理解气候变化在预测慢性病中的作用。 在农村非裔美国人中实现老龄化(CDA)，并为此制定预防方案 弱势群体。使用最近开发的生物风化的直接测量方法，我们发现， 到20岁时，由于心理社会背景，一些Shaape年轻人已经经历了加速衰老。这个 向成年期的过渡提供了一个机会来研究新的和持续的来源的影响 在这一重要的过渡时期，对风化的风险和复原力以及最终对CDA脆弱性的影响， 使我们能够仔细检查可能出现的不利和保护性体验，从而使风险曲线“弯曲” 未来的CDA等阐明了预防性干预的主要目标。在此，我们请求资金补充 通过使用来自NICHD赞助的正在进行的数据收集协议的血液来表征SHAPE研究 每个参与者在26岁时的“表观遗传钟”，提供了一个关键的窗口，风化和变化 风化等使我们能够进行加强的理论测试，并更准确地识别高价值 预防性干预的目标。通过添加此评估，我们将拥有一个包含以下度量的数据集 20岁和26岁的生物风化，以及代谢综合征的全部指标， 2型糖尿病和心血管疾病的先兆。这项评估不会给 塑造参与者，并将大大增加数据集的公共健康价值。首先，我们将 检查在过渡到的过程中暴露于多维SES和种族相关压力源的影响 成年期对生物风化的影响。我们预计会接触到压力因素，特别是种族因素 歧视，在保持或加速青壮年的老化过程中发挥关键作用 并预测CDA的脆弱性(即代谢风险和炎症)。第二，我们将确定积极的， 家庭内外的保护性影响，帮助将非裔美国年轻人从 以上是CDA的发展轨迹。我们预计，这些因素对年轻人来说将特别重要 进入成年期的成年人已经加速了风化。建议的研究结果 研究将为制定预防干预措施提供信息，旨在减缓生物风化和 促进CDA早期发展的高危人群的健康。通过不仅检查风险因素 对于加速衰老，以及预示着衰老减速的保护性环境和应对过程 生物衰老跨过青壮年，我们将拥有新一代 专门为阻止风化和促进农村居民的健康和福祉而设计的预防方案 非裔美国人，从而解决了有据可查的健康差距。

PROJECT SUMMARY The current proposal builds upon an ongoing investigation to test hypotheses about (1) the role of psychosocial stressors in “weathering” young bodies, (2) the protective factors that may mitigate their adverse impact, and (3) the role of continuity and change in weathering during a key life course transition. Tests of these hypotheses will enable a better understanding of the role of weathering in forecasting chronic diseases of aging (CDAs) among rural African Americans and set the stage for prevention programming for this vulnerable population. Using recently-developed, direct measures of biological weathering we have found that, by age 20, some SHAPE youth are already experiencing accelerated aging due to psychosocial context. The transition to adulthood provides an opportunity to examine the impact of both new and continuing sources of risk and resilience on weathering and ultimately on CDA vulnerability during this important transition period, allowing us to closely examine the potential for adverse and protective experiences to “bend” the risk curve for future CDAs and so illuminate key targets for preventive intervention. Here, we request funds to supplement the SHAPE study by using blood from an ongoing NICHD-sponsored data collection protocol to characterize each participant's “epigenetic clock” at age 26, providing a key window on weathering and changes in weathering and so allow us to conduct enhanced tests of theory and to more accurately identify high value targets for preventive intervention. By adding this assessment we will have a data set with measures of biological weathering at age 20 and age 26, along with a full complement of indicators of metabolic syndrome, a precursor to type 2 diabetes and cardiovascular disease. This assessment will place no additional burden on SHAPE participants and will substantially increase the public health value of the data set. First, we will examine the impact of exposure to multidimensional SES- and race-related stressors during the transition to adulthood on changes in biological weathering. We expect exposure to stressors, particularly racial discrimination, to play a key role in maintaining or accelerating weathering processes across young adulthood and to presage CDA vulnerability (i.e. metabolic risk and inflammation). Second, we will identify positive, protective influences, both inside and outside the family, that help shift African American young adults off the above-mentioned trajectory to CDAs. We anticipate that these factors will be especially important for young adults who enter the transition to adulthood with already-accelerated weathering. The results of the proposed study will inform the development of preventive interventions designed to slow biological weathering and promote health for a population at high risk for early development of CDAs. By examining not only risk factors for accelerated aging but also protective environments and coping processes that presage a deceleration of biological aging across young adulthood, we will have the necessary ingredients for a new generation of prevention programs designed specifically to deter weathering and promote the health and well-being of rural African Americans, thereby addressing well-documented health disparities.