Origin of Chronic Diseases of Aging Among Rural African American Young Adults
农村非裔美国年轻人慢性衰老疾病的起源
基本信息
- 批准号:9925262
- 负责人:
- 金额:$ 16.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-20 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAdolescenceAdolescentAdoptionAdultAfrican AmericanAgeAgingAttentionBiologicalBiological AgingBiological MarkersBloodBuffersCardiovascular DiseasesChildhoodChronic DiseaseChronologyCommunitiesComplementDataData CollectionData SetDecelerationDevelopmentDisadvantagedDiscriminationEducationEnvironmentEpidemicEpigenetic ProcessExposure toFamilyFoundationsFundingFutureGenerationsGeneticGlycosylated hemoglobin AGoalsHealthHealth PromotionIndividual DifferencesInflammationInflammatoryInvestigationLife Cycle StagesLife ExperienceLinkLiteratureMaintenanceMeasuresMediatingMediationMetabolicMetabolic MarkerMetabolic syndromeNational Institute of Child Health and Human DevelopmentNon-Insulin-Dependent Diabetes MellitusOccupationsOutcomeParticipantPersonal SatisfactionPhysiologicalPlayPopulationPositioning AttributePreventionPrevention programPreventive InterventionProcessProtocols documentationPublic HealthRaceRequest for ProposalsResearchRespondentRiskRisk FactorsRoleRuralSamplingServicesSourceStressTestingTimeTissuesTriglyceridesUncertaintyVulnerable PopulationsWagesWeatherWorkYouthcopingcostdesignearly experienceearly onsetemerging adultexperiencehealth disparityheuristicshigh riskindexinginsightnovel strategiespeerpreventprospectiveprotective factorspsychosocialracial discriminationracial identityresiliencerural African Americansocialsocial relationshipsstemstressortheoriestherapy designyoung adult
项目摘要
PROJECT SUMMARY
The current proposal builds upon an ongoing investigation to test hypotheses about (1) the role of
psychosocial stressors in “weathering” young bodies, (2) the protective factors that may mitigate their adverse
impact, and (3) the role of continuity and change in weathering during a key life course transition. Tests of
these hypotheses will enable a better understanding of the role of weathering in forecasting chronic diseases
of aging (CDAs) among rural African Americans and set the stage for prevention programming for this
vulnerable population. Using recently-developed, direct measures of biological weathering we have found that,
by age 20, some SHAPE youth are already experiencing accelerated aging due to psychosocial context. The
transition to adulthood provides an opportunity to examine the impact of both new and continuing sources of
risk and resilience on weathering and ultimately on CDA vulnerability during this important transition period,
allowing us to closely examine the potential for adverse and protective experiences to “bend” the risk curve for
future CDAs and so illuminate key targets for preventive intervention. Here, we request funds to supplement
the SHAPE study by using blood from an ongoing NICHD-sponsored data collection protocol to characterize
each participant's “epigenetic clock” at age 26, providing a key window on weathering and changes in
weathering and so allow us to conduct enhanced tests of theory and to more accurately identify high value
targets for preventive intervention. By adding this assessment we will have a data set with measures of
biological weathering at age 20 and age 26, along with a full complement of indicators of metabolic syndrome,
a precursor to type 2 diabetes and cardiovascular disease. This assessment will place no additional burden on
SHAPE participants and will substantially increase the public health value of the data set. First, we will
examine the impact of exposure to multidimensional SES- and race-related stressors during the transition to
adulthood on changes in biological weathering. We expect exposure to stressors, particularly racial
discrimination, to play a key role in maintaining or accelerating weathering processes across young adulthood
and to presage CDA vulnerability (i.e. metabolic risk and inflammation). Second, we will identify positive,
protective influences, both inside and outside the family, that help shift African American young adults off the
above-mentioned trajectory to CDAs. We anticipate that these factors will be especially important for young
adults who enter the transition to adulthood with already-accelerated weathering. The results of the proposed
study will inform the development of preventive interventions designed to slow biological weathering and
promote health for a population at high risk for early development of CDAs. By examining not only risk factors
for accelerated aging but also protective environments and coping processes that presage a deceleration of
biological aging across young adulthood, we will have the necessary ingredients for a new generation of
prevention programs designed specifically to deter weathering and promote the health and well-being of rural
African Americans, thereby addressing well-documented health disparities.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gene H. Brody其他文献
Effects of residential instability on Head Start children and their relationships with older siblings: influences of child emotionality and conflict between family caregivers.
居住不稳定对启蒙儿童及其与年长兄弟姐妹关系的影响:儿童情绪和家庭照顾者之间冲突的影响。
- DOI:
10.1111/1467-8624.00090 - 发表时间:
1999 - 期刊:
- 影响因子:4.6
- 作者:
Z. Stoneman;Gene H. Brody;Susan L. Churchill;Laura L. Winn - 通讯作者:
Laura L. Winn
Contributions of protective and risk factors to literacy and socioemotional competency in former head start children attending kindergarten
保护性因素和风险因素对上幼儿园的前启蒙儿童的识字能力和社会情感能力的贡献
- DOI:
- 发表时间:
1994 - 期刊:
- 影响因子:0
- 作者:
Gene H. Brody;Z. Stoneman;J. McCoy - 通讯作者:
J. McCoy
Gene H. Brody的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gene H. Brody', 18)}}的其他基金
Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention
神经科学、免疫学、社会逆境和成瘾行为的根源:建立药物使用病因学和预防的新框架
- 批准号:
10023720 - 财政年份:2020
- 资助金额:
$ 16.82万 - 项目类别:
Research Project 2: Can Family-Centered Prevention Programming Reduce Neuroimmune Vulnerabilities for Drug Use and Health Risk among African American Adolescents?: A Randomized Prevention Trial
研究项目 2:以家庭为中心的预防规划能否减少非裔美国青少年吸毒和健康风险的神经免疫脆弱性?:随机预防试验
- 批准号:
10455002 - 财政年份:2020
- 资助金额:
$ 16.82万 - 项目类别:
Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention
神经科学、免疫学、社会逆境和成瘾行为的根源:建立药物使用病因学和预防的新框架
- 批准号:
10240665 - 财政年份:2020
- 资助金额:
$ 16.82万 - 项目类别:
Research Project 2: Can Family-Centered Prevention Programming Reduce Neuroimmune Vulnerabilities for Drug Use and Health Risk among African American Adolescents?: A Randomized Prevention Trial
研究项目 2:以家庭为中心的预防规划能否减少非裔美国青少年吸毒和健康风险的神经免疫脆弱性?:随机预防试验
- 批准号:
10023725 - 财政年份:2020
- 资助金额:
$ 16.82万 - 项目类别:
Research Project 2: Can Family-Centered Prevention Programming Reduce Neuroimmune Vulnerabilities for Drug Use and Health Risk among African American Adolescents?: A Randomized Prevention Trial
研究项目 2:以家庭为中心的预防规划能否减少非裔美国青少年吸毒和健康风险的神经免疫脆弱性?:随机预防试验
- 批准号:
10240670 - 财政年份:2020
- 资助金额:
$ 16.82万 - 项目类别:
Research Project 2: Can Family-Centered Prevention Programming Reduce Neuroimmune Vulnerabilities for Drug Use and Health Risk among African American Adolescents?: A Randomized Prevention Trial
研究项目 2:以家庭为中心的预防规划能否减少非裔美国青少年吸毒和健康风险的神经免疫脆弱性?:随机预防试验
- 批准号:
10670898 - 财政年份:2020
- 资助金额:
$ 16.82万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 16.82万 - 项目类别:
Research Grant