Origin of Chronic Diseases of Aging Among Rural African American Young Adults

农村非裔美国年轻人慢性衰老疾病的起源

基本信息

批准号：
9925262
负责人：
Gene H. Brody
金额：
$ 16.82万
依托单位：
UNIVERSITY OF GEORGIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-20 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9925262
关键词：
Acceleration Address Adolescence Adolescent Adoption Adult African American Age Aging Attention Biological Biological Aging Biological Markers Blood Buffers Cardiovascular Diseases Childhood Chronic Disease Chronology Communities Complement Data Data Collection Data Set Deceleration Development Disadvantaged Discrimination Education Environment Epidemic Epigenetic Process Exposure to Family Foundations Funding Future Generations Genetic Glycosylated hemoglobin A Goals Health Health Promotion Individual Differences Inflammation Inflammatory Investigation Life Cycle Stages Life Experience Link Literature Maintenance Measures Mediating Mediation Metabolic Metabolic Marker Metabolic syndrome National Institute of Child Health and Human Development Non-Insulin-Dependent Diabetes Mellitus Occupations Outcome Participant Personal Satisfaction Physiological Play Population Positioning Attribute Prevention Prevention program Preventive Intervention Process Protocols documentation Public Health Race Request for Proposals Research Respondent Risk Risk Factors Role Rural Sampling Services Source Stress Testing Time Tissues Triglycerides Uncertainty Vulnerable Populations Wages Weather Work Youth coping cost design early experience early onset emerging adult experience health disparity heuristics high risk indexing insight novel strategies peer prevent prospective protective factors psychosocial racial discrimination racial identity resilience rural African American social social relationships stem stressor theories therapy design young adult

项目摘要

PROJECT SUMMARY The current proposal builds upon an ongoing investigation to test hypotheses about (1) the role of psychosocial stressors in “weathering” young bodies, (2) the protective factors that may mitigate their adverse impact, and (3) the role of continuity and change in weathering during a key life course transition. Tests of these hypotheses will enable a better understanding of the role of weathering in forecasting chronic diseases of aging (CDAs) among rural African Americans and set the stage for prevention programming for this vulnerable population. Using recently-developed, direct measures of biological weathering we have found that, by age 20, some SHAPE youth are already experiencing accelerated aging due to psychosocial context. The transition to adulthood provides an opportunity to examine the impact of both new and continuing sources of risk and resilience on weathering and ultimately on CDA vulnerability during this important transition period, allowing us to closely examine the potential for adverse and protective experiences to “bend” the risk curve for future CDAs and so illuminate key targets for preventive intervention. Here, we request funds to supplement the SHAPE study by using blood from an ongoing NICHD-sponsored data collection protocol to characterize each participant's “epigenetic clock” at age 26, providing a key window on weathering and changes in weathering and so allow us to conduct enhanced tests of theory and to more accurately identify high value targets for preventive intervention. By adding this assessment we will have a data set with measures of biological weathering at age 20 and age 26, along with a full complement of indicators of metabolic syndrome, a precursor to type 2 diabetes and cardiovascular disease. This assessment will place no additional burden on SHAPE participants and will substantially increase the public health value of the data set. First, we will examine the impact of exposure to multidimensional SES- and race-related stressors during the transition to adulthood on changes in biological weathering. We expect exposure to stressors, particularly racial discrimination, to play a key role in maintaining or accelerating weathering processes across young adulthood and to presage CDA vulnerability (i.e. metabolic risk and inflammation). Second, we will identify positive, protective influences, both inside and outside the family, that help shift African American young adults off the above-mentioned trajectory to CDAs. We anticipate that these factors will be especially important for young adults who enter the transition to adulthood with already-accelerated weathering. The results of the proposed study will inform the development of preventive interventions designed to slow biological weathering and promote health for a population at high risk for early development of CDAs. By examining not only risk factors for accelerated aging but also protective environments and coping processes that presage a deceleration of biological aging across young adulthood, we will have the necessary ingredients for a new generation of prevention programs designed specifically to deter weathering and promote the health and well-being of rural African Americans, thereby addressing well-documented health disparities.

项目摘要当前的提案基于正在进行的调查，以检验有关（1）作用的假设在“风化”年轻身体中的社会心理压力源，（2）受保护的因素可能会减轻对抗影响，以及（3）在关键生活过程中，连续性和变化在风化中的作用。测试这些假设将更好地理解风化在预测慢性疾病中的作用在粗糙的非裔美国人中衰老（CDA），为此奠定了预防节目的舞台脆弱的人口。使用最近开发的，直接测量生物风化的测量，我们发现，到20岁时，由于心理社会环境，一些年轻人已经在加速衰老。过渡到成年，提供了一个机会，可以检查新的和持续来源的影响在这个重要过渡期间，风险和韧性在风化以及最终在CDA脆弱性上，使我们能够密切检查不利和受保护的经历的潜力，以“弯曲”风险曲线的风险曲线未来的CDA，并阐明了预防干预的关键目标。在这里，我们要求资金补充通过使用正在进行的NICHD赞助的数据收集协议中的血液来表征形状研究每个参与者在26岁时的“表观遗传钟”，为风化和变化提供了一个关键窗口风化，因此允许我们进行增强的理论测试，并更准确地识别高价值预防干预的目标。通过添加此评估，我们将拥有一个数据集，该数据集具有 20岁和26岁的生物风化，以及代谢综合征指标的完整补充， 2型糖尿病和心血管疾病的前体。该评估不会再燃烧塑造参与者，并大大提高数据集的公共健康价值。首先，我们会的检查在过渡到多维SES和种族相关的压力源的影响成年生物风化的变化。我们希望暴露于压力源，尤其是种族歧视，在维持或加速成年的风化过程中发挥关键作用并预示CDA脆弱性（即代谢风险和炎症）。第二，我们将确定积极的在家庭内外，保护性影响有助于将非洲裔美国年轻人从上述轨迹至CDA。我们预计这些因素对年轻人尤为重要进入已经加入的风化的成年人。提议的结果研究将为旨在减缓生物风化和的预防干预措施的发展提供信息促进CDA早期发展风险高风险的人群的健康。不仅检查风险因素用于加速衰老，但也保护环境和应对过程，以预示减速整个成年的生物衰老专门旨在确定风化和促进农村健康和福祉的预防计划非洲裔美国人，从而解决了有据可查的健康分布。