FASEB SRC: Structure and Function of Small GTPases

FASEB SRC：小 GTP 酶的结构和功能

• 批准号: 10463260
• 负责人: MARK Reid PHILIPS
• 金额: $ 0.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463260
• 关键词: Academy; Achievement; Adhesions; Anniversary; Antineoplastic Agents; Automobile Driving; Award; Binding; Biochemical; Cancer Biology; Cell division; Cell physiology; Clinic; Collaborations; Communities; Cytoskeleton; Development; Drug Design; Educational workshop; Environment; Environment Design; Family; Financial Support; Fostering; Funding; Future; G-Protein-Coupled Receptors; GTP Binding; Gene Expression; Genes; Goals; Growth Factor Receptors; Guanine Nucleotides; Guanosine Triphosphate Phosphohydrolases; Health; Heterotrimeric GTP-Binding Proteins; Human; Human Genome; Industry; Integrins; International; Knowledge; Malignant Neoplasms; Mediating; Metabolism; Mitosis; Molecular; Monomeric GTP-Binding Proteins; Mutate; Neoplasm Metastasis; Nuclear Import; Oncogenes; Oncology; Phagocytosis; Play; Protein Family; Proteins; RAS genes; Request for Applications; Research; Research Personnel; Rivers; Role; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signal Pathway; Signal Transduction; Structure; Syndrome; Technology; Therapeutic; Time; Training; Transistors; Translating; Travel; Underrepresented Minority; Underrepresented Populations; Vermont; Woman; career development; cell growth; cell motility; design; driving force; drug discovery; falls; gene product; guanine nucleotide binding protein; infancy; interest; lectures; meetings; member; metaplastic cell transformation; novel therapeutics; posters; preference; programs; rac1 GTP-Binding Protein; ran GTP-Binding Protein; ras Oncogene; ras Proteins; receptor; recruit; social; summer research; symposium; targeted cancer therapy; tumor growth; tumorigenesis; vesicle transport; virtual

Summary Rational drug design for cancer requires a thorough understanding of signaling networks in order to reveal nodes that can be targeted. Small GTPases are central components of numerous signaling pathway, including many that drive oncogenesis and metastasis. Small GTPases are binary switches that are interconverted from the GDP-bound off to the GTP-bound on state by receptors and regulatory molecules and, when in the on state, drive signaling through various effector molecules. The superfamily of small GTPases number more than 160 gene products and can be divided into five families: RAS, RHO, RAB, ARF and RAN proteins. RAS proteins were the first small GTPases identified and remain the best studied. RAS genes are the oncogenes more frequently mutated in cancer than any other, which accounts for the intense interest in understanding and targeting these GTPases. The FASEB Summer Research Conference on Small GTPases was founded in 1991 and has been held every two years since. The conference has consistently attracted the leaders in the field and has played a large role in driving the field forward and promoting collaborations that have expedited discoveries that have been translated into drug discovery. The conference has also served as a platform for encouraging young investigators to enter the field. This application seeks partial funding for the 30th Anniversary Meeting of the FASEB SRC on the Structure and Function of Small GTPases. The meeting will feature a keynote lecture by Channing Der, one of the co-founders of the meeting who remains a driving force in the field. Also featured will be 28 plenary talks. Fifty percent of the invited speakers are new to the conference and are intended to bring fresh ideas and technologies. Twenty short talks will be selected from submitted abstracts and delivered by young scientists. All attendees will present posters. Opportunities for informal discussions and for networking will abound over the 5-day meeting that will include unscheduled time in the afternoons as well as a Meet-the- Expert lunch and a Career Development breakfast. Forty-three percent of invited speakers are woman. A concerted effort is planned to recruit trainees who are members of underrepresented groups. Ten travel/registration awards will be made to trainees with preference given to underrepresented minorities.

概括 合理的癌症药物设计需要彻底了解信号网络以揭示节点 是可以有针对性的。小 GTP 酶是许多信号通路的核心组成部分，包括许多 驱动肿瘤发生和转移。小 GTPases 是从 GDP 结合通过受体和调节分子转变为 GTP 结合开启状态，并且当处于开启状态时， 通过各种效应分子驱动信号传导。小GTP酶超家族数量超过160个 基因产物可分为五个家族：RAS、RHO、RAB、ARF 和 RAN 蛋白。 RAS蛋白 是第一个被发现的小 GTP 酶，并且仍然是研究最充分的。 RAS基因更多是致癌基因 癌症中的突变频率比其他任何癌症都高，这就是人们对了解和了解癌症的强烈兴趣。 靶向这些 GTPases。 FASEB 小 GTPases 夏季研究会议成立于 1991 年 此后每两年举办一次。会议持续吸引了该领域的领导者和 在推动该领域发展和促进加速发现的合作方面发挥了重要作用 已转化为药物发现。此次会议还为鼓励 年轻的研究者进入该领域。本申请为 30 周年纪念会议寻求部分资金 FASEB SRC 关于小 GTP 酶结构和功能的报告。会议将进行主题演讲 会议的联合创始人之一查宁·德尔 (Channing Der) 至今仍是该领域的推动者。还精选了 将于28日举行全体会议。百分之五十的受邀演讲者是会议的新人，旨在带来 新的想法和技术。将从提交的摘要中选出二十个简短的演讲，并由 年轻的科学家。所有与会者都将展示海报。非正式讨论和交流的机会 为期 5 天的会议将充满大量内容，其中包括下午的计划外时间以及见面会 专家午餐和职业发展早餐。百分之四十三的受邀演讲者是女性。一个 计划共同努力招募属于代表性不足群体的学员。十 将向受训人员提供旅行/注册奖励，并优先考虑代表性不足的少数群体。