Development of a novel method for cannulation in pediatric cardiac procedures

项目摘要 该提案的目标是开发一种快速连接插管系统，以实现快速、简单和安全 儿科心脏病患者的插管。体外膜肺氧合（ECMO）已成为一种 这是拯救心血管和/或呼吸衰竭患者的重要工具。然而，即使在 经验丰富的手，ECMO支持的启动在压力环境中相对耗时， 频繁并发症 本R21提案提交的目标是开发一种新型快速连接插管系统， 允许在儿科人群中进行快速、简单和安全的插管。该提案已提交给PA- 18 - 482在与NICHD项目官员讨论后。我们将通过两个具体目标来实现这一目标。 目的1：开发新型快速插管装置。将开发一种新的快速插管装置， 原型该器械将被设计为牢固地连接到当前市售的动脉和静脉插管上 直径为8Fr-16Fr，并在拉伸试验机上测试机械稳定性。 目的2：在台架和猪动物试验中评价器械。首先将在实验室中对器械进行评价 使用3D打印的心脏模型和闭环加压系统来模拟心脏流量。一旦这些 如果试验成功，将使用我们的其他研究项目中的过期猪进行猪动物试验。 院 这个项目的成功完成将为我们提供一个原型设备，可以走向 未来的工作将包括临床研究，其中包括开发可生物降解的版本。另一种保险箱， 简单、快速的插管过程可以通过最小化插管所需的时间来缩短E-CPR的持续时间。 安全插管，减少甚至防止对大脑和其他器官系统的潜在损害。等 一项创新有可能在死亡率和发病率方面显著改善结果， 接受电子心肺复苏术的儿科患者

Project Summary The goal of this proposal is to develop a quick-connect cannulation system to allow rapid, easy, and safe cannulation in pediatric cardiac patients. Extracorporeal membrane oxygenation (ECMO) has emerged as a vital tool for saving patients suffering cardiovascular and/or respiratory failure. However, even in well experienced hands, the initiation of ECMO support is relatively time consuming in a stressful environment with frequent complications. The goal of this R21 proposal submission is to develop a novel quick-connection cannulation system to allow for rapid, easy, and safe cannulation in the pediatric population. This proposal is being submitted to PA- 18-482 after discussion with NICHD program officers. We will accomplish this through two specific aims. Aim 1: Develop new rapid cannulation device. A new rapid cannulation device will be developed and prototyped. The device will be designed to securely attach to current commercial arterial and venous cannulas from 8Fr-16Fr in diameter and tested for mechanical stability on a tensile testing machine. Aim 2: Evaluate device in bench top and swine animal tests. The device will first be evaluated in a bench test using 3D printed model hearts and a closed loop pressurized system to mimic cardiac flow. Once these tests are successful, swine animal trials will be done using expired pigs from other research projects at our institute. The successful completion of this project will provide us with a prototype device that can move towards clinical studies in future work, which would include developing a biodegradable version. An alternative safe, easy, and fast cannulation procedure may reduce the duration of E-CPR by minimizing the time needed for secure cannulation, reducing or even preventing potential damage to the brain and other organ systems. Such an innovation has the potential to significantly improve outcomes both in terms of mortality and morbidity of pediatric patients undergoing E-CPR.