Development of a novel method for cannulation in pediatric cardiac procedures

项目摘要 这项提议的目标是开发一种快速连接的插管系统，以便快速、容易和安全地 小儿心脏病患者的插管治疗。体外膜氧合(ECMO)已成为一种 抢救心血管和/或呼吸衰竭患者的重要工具。然而，即使在油井中 经验丰富的人，在压力较大的环境中启动ECMO支持相对耗时 并发症频发。 提交此R21提案的目标是开发一种新型快速连接插管系统，以 允许在儿科人群中进行快速、简便和安全的插管。这份提案正在提交给PA- 18-482在与NICHD项目官员讨论后。我们将通过两个具体目标来实现这一目标。 目的1：研制新型快速插管器。将开发一种新的快速插管装置，并 原型。该装置将被设计成安全地连接到目前商用的动脉和静脉插管上 直径从8Fr到16Fr，并在拉伸试验机上测试机械稳定性。 目的2：在实验台和猪动物实验中对该装置进行评价。该装置将首先在长椅上进行评估 使用3D打印模型心脏和模拟心脏流动的闭环加压系统进行测试。一旦这些 测试是成功的，猪动物实验将使用我们的其他研究项目中的过期猪进行 研究所。 该项目的成功完成将为我们提供一个可以向 未来工作中的临床研究，其中将包括开发一种可生物降解的版本。另一种保险箱， 简单、快速的插管程序可以最大限度地缩短电子心肺复苏所需的时间 确保插管安全，减少甚至防止对大脑和其他器官系统的潜在损害。是这样的 一项创新有可能显著改善在死亡率和发病率方面的结果 接受电子心肺复苏术的儿科患者。

Project Summary The goal of this proposal is to develop a quick-connect cannulation system to allow rapid, easy, and safe cannulation in pediatric cardiac patients. Extracorporeal membrane oxygenation (ECMO) has emerged as a vital tool for saving patients suffering cardiovascular and/or respiratory failure. However, even in well experienced hands, the initiation of ECMO support is relatively time consuming in a stressful environment with frequent complications. The goal of this R21 proposal submission is to develop a novel quick-connection cannulation system to allow for rapid, easy, and safe cannulation in the pediatric population. This proposal is being submitted to PA- 18-482 after discussion with NICHD program officers. We will accomplish this through two specific aims. Aim 1: Develop new rapid cannulation device. A new rapid cannulation device will be developed and prototyped. The device will be designed to securely attach to current commercial arterial and venous cannulas from 8Fr-16Fr in diameter and tested for mechanical stability on a tensile testing machine. Aim 2: Evaluate device in bench top and swine animal tests. The device will first be evaluated in a bench test using 3D printed model hearts and a closed loop pressurized system to mimic cardiac flow. Once these tests are successful, swine animal trials will be done using expired pigs from other research projects at our institute. The successful completion of this project will provide us with a prototype device that can move towards clinical studies in future work, which would include developing a biodegradable version. An alternative safe, easy, and fast cannulation procedure may reduce the duration of E-CPR by minimizing the time needed for secure cannulation, reducing or even preventing potential damage to the brain and other organ systems. Such an innovation has the potential to significantly improve outcomes both in terms of mortality and morbidity of pediatric patients undergoing E-CPR.