Viral factors responsible for Lassa virus pathogenicity

拉沙病毒致病性的病毒因素

基本信息

  • 批准号:
    10462688
  • 负责人:
  • 金额:
    $ 6.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-05 至 2023-01-02
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT This career development award will help fill in the knowledge and skills in basic virological research of Risk Group 4 agents, which need to be handled in the highest containment laboratory (BSL-4). This is essential for the goal to become an independent researcher as an expert on highly pathogenic infectious diseases. The goal during the award period is to reveal novel mechanisms of Lassa fever (LF) by using both in vivo and in vitro techniques, leading to new insight into the development of countermeasures and controlling methods against Lassa fever. Lassa virus (LASV) is endemic in West African countries and causes outbreaks of LF annually. Although LASV is one of the most alarming pathogens from a public health perspective, there are few effective vaccines or therapeutics against LF. LASV must be handled at biosafety level 4 (BSL-4), due to its high pathogenicity. This is one of the largest barriers to the development of preventive or therapeutic approaches against LF. Furthermore, animal models of LF are limited, which is essential for basic research and development of countermeasures. Recently, we developed a novel guinea pig model of LF and found that LASV strain LF2384 and LF2350 have completely different pathogenic phenotypes in guinea pigs. These two viruses have been isolated from human LF patients and pathogenicity of these viruses in guinea pigs is consistent with human cases. These unique combinations of immunocompetent rodent model and clinical isolated LASVs are strong tools, which allow us to reveal viral factors responsible for pathogenicity and molecular mechanisms underlying LASV pathogenicity. In the proposed study, we will determine factors responsible for LASV pathogenicity and reveal novel molecular mechanisms underlying LASV infection by using reverse genetics, in vivo experiments, and several in vitro molecular techniques. We will address this goal through three specific aims. In Specific Aim 1, we will reveal the pathophysiology of LASV infection in guinea pigs. In Specific Aim 2, we will determine viral factors responsible for LASV pathogenicity by using reverse genetics and in vivo study. In Specific Aim 3, we will unveil molecular mechanisms underlying LASV pathogenicity. Taken together, we hope to address novel pathogenic mechanisms of LASV infection, leading to new insights to develop countermeasures against LF.
项目总结/文摘

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Unbiased approach to identify and assess efficacy of human SARS-CoV-2 neutralizing antibodies.
  • DOI:
    10.1038/s41598-022-19780-7
  • 发表时间:
    2022-09-15
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Cao, Xia;Maruyama, Junki;Zhou, Heyue;Fu, Yanwen;Kerwin, Lisa;Powers, Colin;Sattler, Rachel A.;Manning, John T.;Singh, Alok;Lim, Reyna;Healy, Laura D.;Johnson, Sachi;Cabral, Elizabeth Paz;Li, Donghui;Lu, Lucy;Ledesma, Arthur;Lee, Daniel;Richards, Susan;Rivero-Nava, Laura;Li, Yan;Shen, Weiqun;Stegman, Karen;Blair, Benjamin;Urata, Shinji;Kishimoto-Urata, Magumi;Ko, Jamie;Du, Na;Morais, Kyndal;Lawrence, Kate;Rivera, Ianne;Pai, Chin-, I;Bresson, Damien;Brunswick, Mark;Zhang, Yanliang;Ji, Henry;Paessler, Slobodan;Allen, Robert D.
  • 通讯作者:
    Allen, Robert D.
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Junki Maruyama其他文献

Junki Maruyama的其他文献

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{{ truncateString('Junki Maruyama', 18)}}的其他基金

Viral factors responsible for Lassa virus pathogenicity
拉沙病毒致病性的病毒因素
  • 批准号:
    10301541
  • 财政年份:
    2021
  • 资助金额:
    $ 6.32万
  • 项目类别:
Viral factors responsible for Lassa virus pathogenicity
拉沙病毒致病性的病毒因素
  • 批准号:
    10815139
  • 财政年份:
    2021
  • 资助金额:
    $ 6.32万
  • 项目类别:

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